Maximal fat oxidation rate is higher in fit women and unfit women with obesity, compared to normal weight unfit women
Research output: Contribution to journal › Journal article › Research › peer-review
INTRODUCTION: Maximal fat oxidation rate (MFO) is higher in aerobically fit vs. unfit young men, but this training related increase in MFO is attenuated in middle-aged men. Further, it has also been found that unfit men with obesity may have an elevated MFO compared to unfit normal-weight men.
AIM/HYPOTHESIS: Based hereupon, we aimed to investigate whether a fitness related higher MFO were attenuated in middle-aged women compared to young women. Also, we aimed to investigate if unfit women with obesity have a higher MFO compared to unfit normal-weight women. We hypothezised that the training related elevated MFO was attenuated in middle-aged women, but that unfit women with obesity would have an elevated MFO compared to unfit normal-weight women.
METHODS: We recruited a total of 70 women stratified into six groups: Young fit (n=12), young unfit (n=12) middle-aged fit (n=12), middle-aged unfit (n=12), unfit young women with obesity (n=12) and unfit middle-aged women with obesity (n=10). Body composition and resting blood samples were obtained and MFO was measured by a graded exercise test on a cycle ergometer via indirect calorimetry. Subsequently, a maximal exercise test was performed to establish V̇O2peak.
RESULTS: Young and middle-aged fit women had a higher MFO compared to age-matched unfit women, and young fit women had a higher MFO compared to fit middle-aged women. Unfit women with obesity, independent of age, had a higher MFO compared to their normal-weight and unfit counterparts.
CONCLUSION: The training related increase in MFO seems maintained in middle-aged women and secondly, we find that unfit women with obesity, independent of age have a higher MFO compared to unfit normal-weight women.
Original language | English |
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Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 106 |
Issue number | 11 |
Pages (from-to) | E4389-E4399 |
Number of pages | 11 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ID: 279265994