Novo Nordisk Foundation Center for Basic Metabolic Research

A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals

Jensen, J. B., Dollerup, O. L., Møller, A. B., Billeskov, T. B., Kellezi, Emilie Dalbram, Chubanava, Sabina, Damgaard, Mads Vargas, Dellinger, R. W., Trošt, K., Moritz, Thomas, Ringgaard, S., Møller, N., Treebak, Jonas Thue, Farup, J. & Jessen, N., 2022, In: JCI insight. 7, 19, 15 p., e158314.

Research output: Contribution to journal › Journal article › Research › peer-review

Reply - Letter to the editor - On carbohydrate restriction and health-related quality of life and cognition in type 2 diabetes

Jensen, N. J., Thomsen, M. N., Skytte, M. J., Astrup, A., Holst, Jens Juul, Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Haugaard, Steen Bendix, Krarup, T. & Rungby, Jørgen, 2022, In: Clinical Nutrition. 41, 9, p. 2061-2062 2 p.

Research output: Contribution to journal › Comment/debate › Research

Weight-loss induced by carbohydrate restriction does not negatively affect health-related quality of life and cognition in people with type 2 diabetes: A randomised controlled trial

Jensen, N. J., Wodschow, H. Z., Skytte, M. J., Samkani, A., Astrup, A., Frystyk, J., Hartmann, Bolette, Holst, Jens Juul, Larsen, T. M., Madsbad, Sten, Magkos, Faidon, Miskowiak, Kamilla, Haugaard, Steen Bendix, Krarup, T., Rungby, Jørgen & Thomsen, M. N., 2022, In: Clinical Nutrition. 41, 7, p. 1605-1612 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment

Jensen, Simon Birk Kjær, Janus, C., Lundgren, J. R., Juhl, C. R., Sandsdal, Rasmus Michael, Olsen, L. M., Andresen, A., Borg, S. A., Jacobsen, I. C., Finlayson, G., Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten & Torekov, Signe Sørensen, 2022, In: Nature Communications. 13, 1, 11 p., 4770.

Research output: Contribution to journal › Journal article › Research › peer-review

Possible prediction of obesity-related liver disease in children and adolescents using indices of body composition

Johansen, M. J., Lund, Morten Asp Vonsild, Ängquist, Lars, Fonvig, Cilius Esmann, Holm, L. A., Chabanova, E., Thomsen, Henrik S., Hansen, Torben & Holm, Jens-Christian, 2022, In: Pediatric Obesity. 17, 10, 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020

Johansen, M., Svenstrup, K., Joensen, P., Steig, B., Andorsdóttir, G., Hansen, Torben & Petersen, M. S., 2022, In: Annals of Clinical and Translational Neurology. 9, 2, p. 227-231

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes

Johansen, N. J., Dejgaard, T. F., Lund, A., Schlüntz, Camilla, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 221-227

Research output: Contribution to journal › Journal article › Research › peer-review

External validation of a genetic risk score that predicts development of alcohol-related cirrhosis

Johansen, S., Thiele, M., Juel, H. B., Hansen, Torben & Krag, A., 2022, In: Journal of Hepatology. 77, 6, p. 1720-1721 2 p.

Research output: Contribution to journal › Comment/debate › Research

An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention

Jørsboe, E., Andersen, M. K., Skotte, L., Stæger, F. F., Færgeman, N. J., Hanghøj, K., Santander, C. G., Senftleber, N. K., Diaz, L. J., Overvad, M., Waples, R. K., Geller, F., Bjerregaard, P., Melbye, M., Larsen, C. V. L., Feenstra, B., Anders Koch, K., Jørgensen, M. E., Grarup, N., Moltke, I. & 2 others, Albrechtsen, Anders & Hansen, Torben, 2022, In: Human Genetics and Genomics Advances. 3, 4, 10 p., 100118.

Research output: Contribution to journal › Journal article › Research › peer-review

Efficient approaches for large-scale GWAS with genotype uncertainty

Jørsboe, E. & Albrechtsen, Anders, 2022, In: G3: Genes, Genomes, Genetics (Bethesda). 12, 1, 9 p., jkab385.

Research output: Contribution to journal › Journal article › Research › peer-review

Off-label Prescription, Adverse Drug Events and Dosage of Psychotropic Drugs in Children and Adolescents with Obesity: A Retrospective Cohort Study

Kamronn, T. M., Gade, Christina, Nielsen, S., Christensen, H. R., Dalhoff, Kim, Holm, Jens-Christian & Holst, H., 2022, In: Acta Scientific Pharmaceutical Sciences. 6, 6, p. 4-16 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Havulinna, A. S., Veturi, Y., Pacheco, J. A., Rosenthal, E. A., Lingren, T., Feng, Q. P., Kullo, I. J., Narita, A., Takayama, J., Martin, H. C., Hunt, K. A., Trivedi, B., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Rasheed, A., Hindy, G., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Choudhury, A., Sengupta, D., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J. H., Matsuda, F., Jang, H. M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Yousri, N. A., Mitchell, R. E., Chai, J. F., Aadahl, Mette, Bjerregaard, A. A., Yao, J., Manichaikul, A., Hwu, C. M., Hung, Y. J., Warren, H. R., Ramirez, J., Bork-Jensen, J., Kårhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Mauro, P., Matteo, F., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, L. T., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Ruotsalainen, S. E., Daw, E., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Vazquez-Moreno, M., Feitosa, M. F., Wojczynski, M. K., Wang, Z., Preuss, M. H., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Tsao, N. L., Verma, A., Slieker, R. C., Lo, K. S., Zilhao, N. R., Le, P., Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Demirkan, A., Leonard, H. L., Marten, J., Frank, M., Schmidt, B., Smyth, L. J., Cañadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kähönen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Nongmaithem, S. S., Bayyana, S., Stringham, H. M., Irvin, M. R., Oldmeadow, C., Kim, H. N., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Prasad, G., Lorés-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Banas, B., Nardone, G. G., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A. E., Hofer, E., Lin, M., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkänen, N., Cade, B. E., van der Laan, S. W., Chitrala, K. N., Weiss, S., Bentley, A. R., Doumatey, A. P., Adeyemo, A. A., Lee, J. Y., Petersen, E. R. B., Nielsen, A. A., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S. Y., Wang, J. S., Couture, C., Lyytikäinen, L. P., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hidalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Liang, J., Tang, H., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Kawaguchi, T., Thiery, J., Bis, J. C., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jäger, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X. O., Rallidis, L. S., Pedersen, Oluf Borbye, Hansen, Torben, Mitchell, P., Hewitt, A. W., Kähönen, M., Pérusse, L., Bouchard, C., Tönjes, A., Chen, Y. D. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellström, D., Cho, Y. S., Lee, H., Yuan, J. M., Koh, W. P., Rhee, S. Y., Woo, J. T., Heid, I. M., Stark, K. J., Zimmermann, M. E., Völzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Peyser, P. A., Kato, N., Schulze, M. B., Girotto, G., Böger, C. A., Jung, B., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Tusié-Luna, T., Aguilar-Salinas, C. A., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J. Y., Zheng, W., Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C. K., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H. L., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Hunt, S. C., Walker, M., Koistinen, H. A., Chandak, G. R., Mercader, J. M., Costanzo, M. C., Jang, D., Burtt, N. P., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E., van Dam, R. M., Lehtimäki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jöckel, K. H., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Jin, Z. B., Qu, J., Hishigaki, H., Lin, X., März, W., Gudnason, V., Tardif, J. C., Lettre, G., Hart, L. M. T., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, Ruth, Province, M. A., Parra, E. J., Cruz, M., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Rotimi, C. N., Christensen, K., Ripatti, S., Widén, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, Allan René, Jukema, J. W., Khera, A. V., Männikkö, M., Jarvelin, M. R., Kutalik, Z., Francesco, C., Mook-Kanamori, D. O., van Dijk, K. W., Watkins, H., Strachan, D. P., Grarup, Niels, Sever, P., Poulter, N., Chuang, L. M., Rotter, J. I., Dantoft, T. M., Karpe, F., Neville, M. J., Timpson, N. J., Cheng, C. Y., Wong, T. Y., Khor, C. C., Li, H., Sabanayagam, C., Peters, A., Gieger, C., Hattersley, A. T., Pedersen, N. L., Magnusson, P. K. E., Boomsma, D. I., Willemsen, A. H. M., Cupples, L., van Meurs, J. B. J., Ghanbari, M., Gordon-Larsen, P., Huang, W., Kim, Y. J., Tabara, Y., Wareham, N. J., Langenberg, C., Zeggini, E., Kuusisto, J., Laakso, M., Ingelsson, E., Abecasis, G., Chambers, J. C., Kooner, J. S., de Vries, P. S., Morrison, A. C., Hazelhurst, S., Ramsay, M., North, K. E., Daviglus, M., Kraft, P., Martin, N. G., Whitfield, J. B., Abbas, S., Saleheen, D., Walters, R. G., Holmes, M. V., Black, C., Smith, B. H., Baras, A., Justice, A. E., Buring, J. E., Ridker, P. M., Chasman, D. I., Kooperberg, C., Tamiya, G., Yamamoto, M., van Heel, D. A., Trembath, R. C., Wei, W. Q., Jarvik, G. P., Namjou, B., Hayes, M. G., Ritchie, M. D., Jousilahti, P., Salomaa, V., Hveem, K., Åsvold, B. O., Kubo, M., Kamatani, Y., Okada, Y., Murakami, Y., Kim, B. J., Thorsteinsdottir, U., Stefansson, K., Zhang, J., Chen, Y., Ho, Y. L., Lynch, J. A., Rader, D. J., Tsao, P. S., Chang, K. M., Cho, K., O'Donnell, C. J., Gaziano, J. M., Wilson, P. W. F., Frayling, T. M., Hirschhorn, J. N., Kathiresan, S., Mohlke, K. L., Sun, Y. V., Morris, A. P., Boehnke, M., Brown, C. D., Natarajan, P., Deloukas, P., Willer, C. J., Assimes, T. L. & Peloso, G. M., 2022, In: Genome Biology. 23, 1, 42 p., 268.

Research output: Contribution to journal › Journal article › Research › peer-review

The proteomic profile of the human myotendinous junction

Karlsen, Anders, Gonzalez-Franquesa, A., Jakobsen, J. R., Krogsgaard, Michael R., Koch, M., Kjær, Michael, Schiaffino, S., Mackey, Abigail & Deshmukh, Atul Shahaji, 2022, In: iScience. 25, 2, 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Carbon source availability drives nutrient utilization in CD8⁺ T cells

Kaymak, I., Luda, Katarzyna Maria, Duimstra, L. R., Ma, E. H., Longo, J., Dahabieh, M. S., Faubert, B., Oswald, B. M., Watson, M. J., Kitchen-Goosen, S. M., DeCamp, L. M., Compton, S. E., Fu, Z., DeBerardinis, R. J., Williams, K. S., Sheldon, R. D. & Jones, R. G., 2022, In: Cell Metabolism. 34, 9, p. 1298-1311 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Macrophage activation marker sCD163 is associated with liver injury and hepatic insulin resistance in obese patients before and after Roux-en-Y gastric bypass

Kazankov, K., Bojsen-Møller, K. N., Møller, H. J., Madsbad, Sten & Grønbæk, H., 2022, In: Physiological Reports. 10, 2, 11 p., e15157.

Research output: Contribution to journal › Journal article › Research › peer-review

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα_z

Keen, A. C., Pedersen, M. H., Lemel, L., Scott, D. J., Canals, M., Littler, D. R., Beddoe, T., Ono, Y., Shi, L., Inoue, A., Javitch, J. A. & Lane, J. R., 2022, In: Communications Biology . 5, 1, 10 p., 256.

Research output: Contribution to journal › Journal article › Research › peer-review

Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle

Kido, K., Egawa, T., Watanabe, S., Kawanaka, K., Treebak, Jonas Thue & Hayashi, T., 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 322, 5, p. E425-E435

Research output: Contribution to journal › Journal article › Research › peer-review

Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial

Klausen, M. K., Jensen, M. E., Møller, M., le Dous, N., Jensen, A-M. Ø., Zeeman, V. A., Johannsen, C-F., Lee, A. M., Thomsen, G. K., Macoveanu, J., Fisher, P. M., Gillum, M. P., Jørgensen, N. R., Bergmann, M. L., Enghusen Poulsen, H., Becker, U., Holst, J. J., Benveniste, H., Volkow, N. D., Vollstädt-Klein, S. & 5 others, Miskowiak, Kamilla, Ekstrøm, Claus Thorn, Knudsen, Gitte Moos, Visboll, T. & Fink-Jensen, Anders, 2022, In: JCI insight. 19, 20 p., e159863.

Research output: Contribution to journal › Journal article › Research › peer-review

The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

Klein, A. B., Nicolaisen, T. S., Johann, K., Fritzen, Andreas Mæchel, Mathiesen, C. V., Gil, Cláudia, Pilmark, N. S., Karstoft, Kristian, Blond, Martin Bæk, Quist, Jonas Salling, Seeley, R. J., Færch, K., Lund, Jens, Kleinert, Maximilian & Clemmensen, Christoffer, 2022, In: Cell Reports. 40, 8, 111258.

Research output: Contribution to journal › Journal article › Research › peer-review

GDF15 in appetite and exercise: Essential player or coincidental bystander?

Klein, A. B., Kleinert, Maximilian, Richter, Erik A. & Clemmensen, Christoffer, 2022, In: Endocrinology. 163, 1, p. 1-10 10 p.

Research output: Contribution to journal › Review › Research › peer-review

Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study

Koopen, A., Witjes, J., Wortelboer, K., Majait, S., Prodan, A., Levin, E., Herrema, H., Winkelmeijer, M., Aalvink, S., Bergman, J. J. G. H. M., Havik, S., Hartmann, B., Levels, H., Bergh, P-O., van Son, J., Balvers, M., Bastos, D. M., Stroes, E., Groen, A. K., Henricsson, M. & 8 others, Kemper, E. M., Holst, Jens Juul, Strauch, C. M., Hazen, S. L., Backhed, F., De Vos, W. M., Nieuwdorp, M. & Rampanelli, E., 2022, In: Gut. 71, p. 1577-1587 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: A randomised, double-blind, active-comparator, non-inferiority clinical trial

Kårhus, M. L., Brønden, A., Forman, Julie Lyng, Haaber, A., Knudsen, E., Langholz, Ebbe, Dragsted, Lars Ove, Hansen, S. H., Krakauer, M., Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2022, In: The Lancet Gastroenterology and Hepatology. 7, 10, p. 922-931 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Enterohepatic, gluco-metabolic, and gut microbial characterization of individuals with bile acid malabsorption

Kårhus, M. L., Sonne, David Peick, Thomasen, M., Ellegaard, A., Holst, Jens Juul, Rehfeld, Jens Frederik, Chávez-Talavera, O., Tailleux, A., Staels, B., Nielsen, Dennis Sandris, Dragsted, Lars Ove, Vilsbøll, Tina, Brønden, A. & Knop, Filip Krag, 2022, In: Gastro Hep Advances. 1, 3, p. 299-312 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Longitudinal evaluation of an mHealth overweight and obesity management tool

Langkjær, I. O. J., Fonvig, Cilius Esmann, Holm, L. A., Pihl, A. F. & Holm, Jens-Christian, 2022, In: mHealth. 8, 11 p., 2.

Research output: Contribution to journal › Journal article › Research › peer-review

Fibroblast growth factor 21 is the main alcohol responsive peptide hormone in humans and individuals with alcohol use disorder exihibit increased plasma concentrations after alcohol intake

Lanng, A., Gasbjerg, Lærke Smidt, Sucksdorff, A., Svenningsen, J., Trammell, Sam, Vilsbøll, Tina, Gillum, M. & Knop, Filip Krag, 2022, In: Journal of Hepatology. 77, S1, p. S121-S121 1 p., THU006.

Research output: Contribution to journal › Conference abstract in journal › Research

Effects of 18-months metformin versus placebo in combination with three insulin regimens on RNA and DNA oxidation in individuals with type 2 diabetes: A post-hoc analysis of a randomized clinical trial

Larsen, E. L., Kjær, L. K., Lundby-Christensen, L., Boesgaard, T. W., Breum, Leif, Gluud, C., Hedetoft, C., Krarup, T., Lund, S. S., Mathiesen, Elisabeth, Perrild, Hans, Sneppen, S. B., Tarnow, L., Thorsteinsson, B., drb459, drb459, Poulsen, Henrik Enghusen, Madsbad, Sten & Almdal, Thomas Peter, 2022, In: Free Radical Biology and Medicine. 178, p. 18-25 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Illumination of the endogenous insulin-regulated TBC1D4 interactome in human skeletal muscle

Larsen, Jeppe Kjærgaard, Larsen, Magnus Romme, Birk, Jesper Bratz, Steenberg, D. E., Hingst, J. R., Højlund, K., Chadt, A., Al-Hasani, H., Deshmukh, Atul Shahaji, Wojtaszewski, Jørgen F P & Kjøbsted, Rasmus, 2022, In: Diabetes. 71, 5, p. 906-920

Research output: Contribution to journal › Journal article › Research › peer-review

Neonatal Anthropometrics and Obesity Treatment Response in Children and Adolescents

Lausten-Thomsen, U., Lund, Morten Asp Vonsild, Stinson, Sara, Frithioff-Bøjsøe, C., Holm, L. A., Baker, J. L., Fonvig, Cilius Esmann, Christiansen, M., Ängquist, Lars, Hansen, Torben & Holm, Jens-Christian, 2022, In: Journal of Pediatrics. 242, p. 74-78.e2 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast

Lengger, B., Hoch-Schneider, E. E., Jensen, C. N., Jakočiū Nas, T., Petersen, A. A., Frimurer, Thomas Michael, Jensen, E. D. & Jensen, M. K., 2022, In: ACS Sensors. 7, 5, p. 1323-1335

Research output: Contribution to journal › Journal article › Research › peer-review

Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk

Leppanen, M. H., Haapala, E. A., Vaisto, J., Ekelund, U., Brage, S., Kilpeläinen, Tuomas O. & Lakka, T. A., 2022, In: Scandinavian Journal of Medicine & Science in Sports. 32, 1, p. 255-266

Research output: Contribution to journal › Journal article › Research › peer-review

The physiology of obesity: from mechanisms to medicine (M2M). Part one

Lewis, J. E. & Aldiss, Peter Stuart Jacob, 2022, In: Journal of Physiology. 600, 4, p. 697-698 2 p.

Research output: Contribution to journal › Editorial › Research

Metagenomic evidence for co-occurrence of antibiotic, biocide and metal resistance genes in pigs

Li, Xuan Ji, Rensing, C., Vestergaard, G., Arumugam, Mani, Nesme, Joseph, Gupta, S., Brejnrod, A. D. & Sørensen, Søren Johannes, 2022, In: Environment International. 158, 10 p., 106899.

Research output: Contribution to journal › Journal article › Research › peer-review

Context dependency of nucleotide probabilities and variants in human DNA

Liang, Yuhu, Grønbæk, Christian, Fariselli, P. & Krogh, Anders, 2022, In: BMC Genomics. 23, 1, 15 p., 87.

Research output: Contribution to journal › Journal article › Research › peer-review

Metabolic control of arginine and ornithine levels paces the progression of leaf senescence

Liebsch, D., Juvany, M., Li, Z., Wang, H., Ziolkowska, A., Chrobok, D., Boussardon, C., Wen, X., Law, S. R., Janečková, H., Brouwer, B., Lindén, P., Delhomme, N., Stenlund, H., Moritz, Thomas, Gardeström, P., Guo, H. & Keech, O., 2022, In: Plant Physiology. 189, 4, p. 1943-1960

Research output: Contribution to journal › Journal article › Research › peer-review

The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

Lindquist, Peter, Gasbjerg, Lærke Smidt, Mokrosinski, J., Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, Mette, 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model

Lorenzen, E., Contreras, V., Olsen, A. W., Andersen, P., Desjardins, D., Rosenkrands, I., Juel, H. B., Delache, B., Langlois, S., Delaugerre, C., Joubert, C., Dereuddre-Bosquet, N., Bébéar, C., De Barbeyrac, B., Touati, A., McKay, P. F., Shattock, R. J., Le Grand, R., Follmann, F. & Dietrich, J., 2022, In: Frontiers in Immunology. 13, 13 p., 1057375.

Research output: Contribution to journal › Journal article › Research › peer-review

An integrated model of obesity pathogenesis that revisits causal direction

Ludwig, D. S. & Sørensen, Thorkild I.A., 2022, In: Nature Reviews Endocrinology. 18, p. 261-262 2 p.

Research output: Contribution to journal › Editorial › Research › peer-review

Outrunning obesity with Lac-Phe?

Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847

Research output: Contribution to journal › Journal article › Research › peer-review

Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model

Lützhøft, Ditte Olsen, Sinioja, T., Christoffersen, B., Jakobsen, Rasmus Riemer, Geng, Dawei, Ahmad, H. F. B., Straarup, E. M., Pedersen, K. M., Kot, Witold, Pedersen, H. D., Cirera, Susanna, Hyötyläinen, T., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: BMC Microbiology. 22, 1, 287.

Research output: Contribution to journal › Journal article › Research › peer-review

Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures

Madsen, J. J., Ye, L., Frimurer, Thomas Michael & Olsen, O. H., 2022, In: Protein Science. 31, 11, 16 p., e4456.

Research output: Contribution to journal › Journal article › Research › peer-review

Coming Closer to Citizens? Frustrated Dialogue on the Danish Health Authority's Facebook Page During COVID-19

Madvig, F., Achiam, Marianne, Adler-Nissen, Rebecca, Johansen, Nicklas & Whiteley, Louise, 2022, In: Frontiers in Communication. 7, 822471.

Research output: Contribution to journal › Journal article › Research › peer-review

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, Miguel-Escalada, I., Della Briotta Parolo, P., Lin, K., Bragg, F., Preuss, M. H., Takeuchi, F., Nano, J., Guo, X., Lamri, A., Nakatochi, M., Scott, R. A., Lee, J., Huerta-Chagoya, A., Graff, M., Chai, J., Parra, E. J., Yao, J., Bielak, L. F., Grarup, Niels, Chen, W., Bork-Jensen, J., Islam, M. T., Jørgensen, M. E., Jørgensen, T., Linneberg, Allan René, Witte, D. R., Lind, L., Loos, Ruth, Hansen, Torben, Pedersen, Oluf Borbye & FinnGen, F., 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling

Maimets, Martti, Pedersen, M. T., Guiu, J., Dreier, J., Thodberg, Malte, Antoku, Yasuko, Schweiger, P. J., Rib, Leonor, Bardini Bressan, Raul, Miao, Y., Garcia, K. C., Sandelin, Albin Gustav, Serup, Palle & Jensen, Kim Bak, 2022, In: Nature Communications. 13, 12 p., 715.

Research output: Contribution to journal › Journal article › Research › peer-review

Thyrotropin-releasing hormone induces Ca²⁺ increase in a subset of vagal nodose ganglion neurons

Mamedova, Esmira, Dmytriyeva, O. & Rekling, Jens Christian, 2022, In: Neuropeptides. 94, 9 p., 102261.

Research output: Contribution to journal › Journal article › Research › peer-review

DNA Methylation and Gene Expression in Blood and Adipose Tissue of Adult Offspring of Women with Diabetes in Pregnancy - A Validation Study of DNA Methylation Changes Identified in Adolescent Offspring

Manitta, Eleonora, Marques, I. C. F., Bredgaard, S. S., Kelstrup, Louise, Houshmand-Oeregaard, A., Clausen, Tine Dalsgaard, Grunnet, Louise Groth, Mathiesen, Elisabeth, Dalgaard, L. T., Barrès, Romain, Vaag, Allan, Damm, Peter & Hjort, Line, 2022, In: Biomedicines. 10, 6, 15 p., 1244.

Research output: Contribution to journal › Journal article › Research › peer-review

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Maqdasy, S., Lecoutre, S., Renzi, G., Frendo-Cumbo, S., Rizo-Roca, D., Moritz, Thomas, Juvany, M., Hodek, O., Gao, H., Couchet, M., Witting, M., Kerr, A., Bergo, M. O., Choudhury, R. P., Aouadi, M., Zierath, Juleen R, Krook, A., Mejhert, N. & Rydén, M., 2022, In: Nature Metabolism. 4, p. 190-202

Research output: Contribution to journal › Journal article › Research › peer-review

Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

Marabita, F., James, T., Karhu, A., Virtanen, H., Kettunen, K., Stenlund, H., Boulund, F., Hellström, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes, M., Similä, H., Lindholm, M. & 9 others, Widén, E., Ripatti, S., Perälä-Heape, M., Engstrand, L., Nilsson, P., Moritz, Thomas, Miettinen, T., Sallinen, R. & Kallioniemi, O., 2022, In: Cell Systems. 13, 3, p. 241-255.e7

Research output: Contribution to journal › Journal article › Research › peer-review

Lipolysis regulates major transcriptional programs in brown adipocytes

Markussen, L. K., Rondini, E. A., Johansen, O. S., Madsen, J. G. S., Sustarsic, E. G., Marcher, A. B., Hansen, Jacob B., Gerhart-Hines, Zach, Granneman, J. G. & Mandrup, S., 2022, In: Nature Communications. 13, 1, 16 p., 3956.

Research output: Contribution to journal › Journal article › Research › peer-review

Mechanism of glycogen synthase inactivation and interaction with glycogenin

Marr, L., Biswas, Dipsikha, Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., Hudson, C., Bertrand, J. A., Pollard, J., Ranson, N. A., Khatter, H., Eyers, C. E., Sakamoto, Kei & Zeqiraj, E., 2022, In: Nature Communications. 13, 1, 14 p., 3372.

Research output: Contribution to journal › Journal article › Research › peer-review

Arginine-induced glucagon secretion and glucagon-induced enhancement of amino acid catabolism are not influenced by ambient glucose levels in mice

Maruszczak, K., Rasmussen, C., Ceutz, F. R., Ørgaard, A., Elmelund, E., Richter, Michael Martin, Holst, Jens Juul, Winther-Sørensen, Marie & Albrechtsen, Nicolai Jacob Wewer, 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 323, p. E207–E214

Research output: Contribution to journal › Journal article › Research › peer-review

Long-acting amylin analogues for the management of obesity

Mathiesen, D. S., Bagger, J. I. & Knop, Filip Krag, 2022, In: Current Opinion in Endocrinology, Diabetes and Obesity. 29, 2, p. 183-190 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin - physiology and pharmacology

Mathiesen, D. S., Lund, A., Holst, Jens Juul, Knop, Filip Krag, Lutz, T. A. & Bagger, J. I., 2022, In: European Journal of Endocrinology. 186, 6, p. R93-R111

Research output: Contribution to journal › Review › Research › peer-review

Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

Mathur, N., Severinsen, M. C. K., Jensen, M. E., Naver, L., Schrölkamp, Maren, Laye, M. J., Watt, M. J., Nielsen, S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund & Schéele, Camilla Charlotte Nielsen, 2022, In: Frontiers in Cell and Developmental Biology. 10, 12 p., 983899.

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

McCaffery, J. M., Jablonski, K. A., Pan, Q., Astrup, A., Christiansen, Malene Revsbech, Corella, D., Corso, L. M. L., Florez, J. C., Franks, P. W., Gardner, C., Hansen, Torben, Kilpeläinen, Tuomas O., Knowler, W. C., Lindström, J., Saris, W. H. M., Sørensen, Thorkild I.A., Tuomilehto, J., Uusitupa, M., Wing, R. R. & Agurs-Collins, T., 2022, In: Diabetes. 71, 4, p. 669-676 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transforming growth factor β1 impairs the transcriptomic response to contraction in myotubes from women with polycystic ovary syndrome

McIlvenna, L. C., Altıntaş, Ali, Patten, R. K., McAinch, A. J., Rodgers, R. J., Stepto, N. K., Barrès, Romain & Moreno-Asso, A., 2022, In: The Journal of Physiology. 600, 14, p. 3313-3330

Research output: Contribution to journal › Journal article › Research › peer-review

Acute effects of linagliptin on intact and total glucagon-like peptide-1 and gastric inhibitory polypeptide levels in insulin-dependent type 2 diabetes patients with and without moderate renal impairment

Meier, J. J., Quast, D. R., Nauck, M. A., Schenker, N., Deacon, Carolyn F., Holst, Jens Juul, Plum-Mörschel, L. & Kapitza, C., 2022, In: Diabetes, Obesity and Metabolism. 24, 5, p. 806-815

Research output: Contribution to journal › Journal article › Research › peer-review

A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity

Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.

Research output: Contribution to journal › Journal article › Research › peer-review

Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts

Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, Kuipers, F., Nieuwdorp, M. & Groen, A. K., 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Microbiome-derived ethanol in nonalcoholic fatty liver disease

Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, Vonghia, L., Francque, S., Beuers, U., Gerdes, V. E. A., Bäckhed, F., Groen, A. K. & Nieuwdorp, M., 2022, In: Nature Medicine. 28, p. 2100-2106

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits

Merino, J., Dashti, H. S., Sarnowski, C., Lane, J. M., Todorov, Petar Vladimirov, Udler, M. S., Song, Y., Wang, H., Kim, J., Tucker, C., Campbell, J., Tanaka, T., Chu, A. Y., Tsai, L., Pers, Tune H, Chasman, D., Rutter, M. K., Dupuis, J., Florez, J. C. & Saxena, R., 2022, In: Nature Human Behaviour. 6, p. 155-163 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

Metz, Sophia, Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, Christina, Neville, M. J., Christiansen, Malene Revsbech, Jonsson, Anna Elisabet, Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, Niklas Rye, Karpe, F., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.

Research output: Contribution to journal › Journal article › Research › peer-review

Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication

Mikkelsen, Christina, Larsen, M. A. H., Sørensen, E., Hansen, Thomas Folkmann, Mikkelsen, S., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Kessing, Lars Vedel, Werge, Thomas, Ullum, H., Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Thørner, L. W. & Didriksen, Maria, 2022, In: Psychiatry Research. 318, 7 p., 114944.

Research output: Contribution to journal › Journal article › Research › peer-review

The new donor vigilance system in Denmark reveals regional differences in adverse reactions supposedly caused by variation in the registration

Mikkelsen, Christina, Paarup, H. M., Bruun, M. T., Pedersen, L. Ø., Hasslund, S., Larsen, R., Aagaard, B. & Sørensen, B. S., 2022, In: Vox Sanguinis. 117, 3, p. 321-327

Research output: Contribution to journal › Journal article › Research › peer-review

Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.

Research output: Contribution to journal › Journal article › Research › peer-review

Recombinant human β-defensin 2 delivery improves smoking-induced lung neutrophilia and bacterial exacerbation

Milad, N., Pineault, M., Bouffard, G., Maranda-Robitaille, M., Lechasseur, A., Beaulieu, M. J., Aubin, S., Jensen, Benjamin Anderschou Holbech & Morissette, M. C., 2022, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 323, 1, p. L37-L47 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Elucidating the relationship between migraine risk and brain structure using genetic data

International Headache Genetics Consortium, I. H. G. C., 1 Sep 2022, In: Brain. 145, 9, p. 3214-3224 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation

Moharrek, Farideh, Ingerslev, L. R., Altıntaş, Ali, Lundell, L., Hansen, Ann Normann, Small, Lewin Barkla, Workman, C. T. & Barrès, Romain, 2022, In: Epigenomics. 14, 21, p. 1305-1324 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Protocol to characterize mitochondrial supercomplexes from mouse tissues by combining BN-PAGE and MS-based proteomics

Moreno Justicia, Roger, Gonzalez-Franquesa, A., Stocks, Ben Nicholas & Deshmukh, Atul Shahaji, 2022, In: STAR Protocols. 3, 1, 21 p., 101135.

Research output: Contribution to journal › Journal article › Research › peer-review

Differential Brain and Cerebrospinal Fluid Proteomic Responses to Acute Prenatal Endotoxin Exposure

Muk (Mudi), Tik, Stensballe, A., Dmytriyeva, O., Brunse, Anders, Jiang, Pingping, Thymann, Thomas, Sangild, Per Torp & Pankratova, Stanislava, 2022, In: Molecular Neurobiology. 59, p. 2204–2218

Research output: Contribution to journal › Journal article › Research › peer-review

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

Nakao, T., Bick, A. G., Taub, M. A., Zekavat, S. M., Uddin, M. M., Niroula, A., Carty, C. L., Lane, J., Honigberg, M. C., Weinstock, J. S., Pampana, A., Gibson, C. J., Griffin, G. K., Clarke, S. L., Bhattacharya, R., Assimes, T. L., Emery, L. S., Stilp, A. M., Wong, Q., Broome, J. & 32 others, Laurie, C. A., Khan, A. T., Smith, A. V., Blackwell, T. W., Codd, V., Nelson, C. P., Yoneda, Z. T., Peralta, J. M., Bowden, D. W., Irvin, M. R., Boorgula, M., Zhao, W., Yanek, L. R., Wiggins, K. L., Hixson, J. E., Charles Gu, C., Peloso, G. M., Roden, D. M., Reupena, M. S., Hwu, C. M., DeMeo, D. L., North, K. E., Kelly, S., Musani, S. K., Bis, J. C., Lloyd-Jones, D. M., Johnsen, J. M., Preuss, M., Tracy, R. P., Loos, Ruth, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, T. S. O. L. A. G. A. S. (. G. & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, N. T. F. P. M. (. C., 2022, In: Science Advances. 8, 14, eabl6579.

Research output: Contribution to journal › Journal article › Research › peer-review

Loss of Function Variants in the XPC Causes Severe Xeroderma Pigmentosum in Three Large Consanguineous Families

Nawal, W., Ullah, A., Ullah, U., Farrakh, K., Ahmad, F., Khan, H., Ahmad, G. S., Khan, B., Ansar, M., Umm-e-Kalsoom & Ahmad, W., 2022, In: Klinische Padiatrie. 234, 3, p. 123-129 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Neopane, K., Kozlov, N., Negoita, F., Murray-Segal, L., Brink, R., Hoque, A., Ovens, A. J., Tjin, G., McAloon, L. M., Yu, D., Ling, N. X. Y., Sanders, M. J., Oakhill, J. S., Scott, J. W., Steinberg, G. R., Loh, K., Kemp, B. E., Sakamoto, Kei & Galic, S., 2022, In: Cell Reports. 41, 12, 26 p., 111862.

Research output: Contribution to journal › Journal article › Research › peer-review

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

Nielsen, C. K., Øhrstrøm, C. C., Kielgast, U. L., Hansen, D. L., Hartmann, Bolette, Holst, Jens Juul, Lund, Asger Bach, Vilsbøll, Tina & Knop, Filip Krag, 2022, In: Diabetes Care. 45, 6, p. 1476–1481

Research output: Contribution to journal › Journal article › Research › peer-review

From trainee to trainer: lessons Learned through implementation of a dual-catheter model in mice

Nielsen, Thomas Svava & Treebak, Jonas Thue, 2022, In: Laboratory Animals. 56, S1, p. 105 1 p., S5C1.2.

Research output: Contribution to journal › Conference abstract in journal › Research

Noninvasive proteomic biomarkers for alcohol-related liver disease

Niu, Lili, Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, Henry, Santos, A., Gupta, R., Meier, F., Strauss, Maximilian, Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, Simon, Hansen, Torben, Krag, A. & Mann, Matthias, 2022, In: Nature Medicine. 28, 6, p. 1277-1287 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, Mallein-Gerin, F., Andersen, J. L., Pennisi, C. P., Clemmensen, Christoffer, Kassem, Moustapha Saad El-Deen, Jafari Kermani, Abbas, Brummelkamp, T., Li, V. S., Wickström, S. A., Olsen, Jesper Velgaard, Blanco, G. & Bekker-Jensen, Simon Holst, 2022, In: E M B O Journal. 41, 17, 19 p., e111650.

Research output: Contribution to journal › Journal article › Research › peer-review

Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

O'Connor, M. J., Schroeder, P., Huerta-Chagoya, A., Cortés-Sánchez, P., Bonàs-Guarch, S., Guindo Martínez, Marta, Cole, J. B., Kaur, V., Torrents, D., Veerapen, K., Grarup, Niels, Kurki, M., Friis, Carsten, Pedersen, Oluf Borbye, Brandslund, I., Linneberg, Allan René, Hansen, Torben, Leong, A., Florez, J. C. & Mercader, J. M., 2022, In: Diabetes. 71, 3, p. 554–565

Research output: Contribution to journal › Journal article › Research › peer-review

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Okbay, A., Wu, Y., Wang, N., Jayashankar, H., Bennett, M., Nehzati, S. M., Sidorenko, J., Kweon, H., Goldman, G., Gjorgjieva, T., Jiang, Y., Hicks, B., Tian, C., Hinds, D. A., Ahlskog, R., Magnusson, P. K. E., Oskarsson, S., Hayward, C., Campbell, A., Porteous, D. J. & 31 others, Freese, J., Herd, P., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., McCreight, J. C., McIntyre, M. H., Mountain, J. L., Northover, C. A. M., Pitts, S. J., Sathirapongsasuti, J. F., Sazonova, O. V., Shelton, J. F., Pers, Tune H, Timshel, P., Ahluwalia, Tarun Veer Singh, Bønnelykke, Klaus, Bisgaard, H., Sørensen, Thorkild I.A., 23andMe Research Team, 2. R. T., Social Science Genetic Association Consortium, S. S. G. A. C. & LifeLines Cohort Study, L. C. S., 2022, In: Nature Genetics. 54, 4, p. 437-449 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Metabolic Role and Therapeutic Potential of the Microbiome

Olofsson, L. E. & Backhed, F., 2022, In: Endocrine Reviews. 43, p. 907-926

Research output: Contribution to journal › Review › Research › peer-review

Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden

Olsson, L. M., Boulund, F., Nilsson, S., Khan, M. T., Gummesson, A., Fagerberg, L., Engstrand, L., Perkins, R., Uhlén, M., Bergström, G., Tremaroli, V. & Bäckhed, F., 2022, In: Cell Host and Microbe. 30, 5, p. 726-739.e3

Research output: Contribution to journal › Journal article › Research › peer-review

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

Pedersen, J. S., Rygg, M. O., Chrøis, K., Sustarsic, E. G., Gerhart-Hines, Zach, Wever Albrechtsen, N. J., Serizawa, R. R., Kristiansen, V. B., Basse, A. L., Boilesen, Astrid Elisabeth Bruun, Olsen, B. H., Hansen, Torben, Gluud, Lise Lotte, Madsbad, Sten, Larsen, S., Bendtsen, Flemming & Dela, Flemming, 2022, In: Nature Communications. 13, 15 p., 2931.

Research output: Contribution to journal › Journal article › Research › peer-review

Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells

Pedersen, Signe Schultz, Prause, Michala Cecilie Burstein, Williams, K., Barrès, Romain & Billestrup, Nils, 2022, In: Journal of Biological Chemistry. 298, 9, 14 p., 102312.

Research output: Contribution to journal › Journal article › Research › peer-review

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J. M., Bidault, G., Vázquez-Borrego, M. C., Dias, A. R., Pucker, B., Dale, M., Campbell, M., Carobbio, S., Lin, Y. H., Vacca, M., Aron-Wisnewsky, J., Mora, S., Masiero, M. M., Emmanouilidou, A. & 8 others, Mukhopadhyay, S., Dougan, G., den Hoed, M., Loos, Ruth, Fernández-Real, J. M., Chiarugi, D., Clément, K. & Vidal-Puig, A., 2022, In: Nature Metabolism. 4, 4, p. 476-494 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Quantitative Phosphoproteomics of the Angiotensin AT2-Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis

Peluso, A. A., Kempf, S. J., Verano-braga, T., Rodrigues-ribeiro, L., Johansen, L. E., Hansen, M. R., Kitlen, G., Haugaard, A. H., Sumners, C., Ditzel, H. J., Santos, R. A., Bader, M., Larsen, M. R. & Steckelings, U. M., 2022, In: Hypertension. 79, 11, p. 2530-2541

Research output: Contribution to journal › Journal article › Research › peer-review

Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals

Petersen, K. F., Dufour, S., Li, F., Rothman, D. L. & Shulman, G. I., 2022, In: JCI insight. 7, 7, 10 p., e157906.

Research output: Contribution to journal › Journal article › Research › peer-review

Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers

Pillon, N. J., Puig, L. S., Altıntaş, Ali, Kamble, P. G., Casaní-Galdón, S., Gabriel, B. M., Barrès, Romain, Conesa, A., Chibalin, A. V., Näslund, E., Krook, A. & Zierath, Juleen R, 2022, In: Life Science Alliance. 6, 1, 14 p., e202201598.

Research output: Contribution to journal › Journal article › Research › peer-review

High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide

Plucinska, Kaja, Mody, N., Dekeryte, R., Shearer, K., Mcilroy, G. D., Delibegovic, M. & Platt, B., 2022, In: Nutritional Neuroscience. 25, 4, p. 719-736 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Association of general health and lifestyle factors with the salivary microbiota – Lessons learned from the ADDITION-PRO cohort

Poulsen, C. S., Nygaard, Nikoline, Constancias, F., Stankevic, Evelina, Kern, T., Witte, D. R., Vistisen, D., Grarup, Niels, Pedersen, Oluf Borbye, Midjord-Belstrøm, Daniel & Hansen, Torben, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 15 p., 1055117.

Research output: Contribution to journal › Journal article › Research › peer-review

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Quarta, C., Stemmer, K., Novikoff, A., Yang, B., Klingelhuber, F., Harger, A., Bakhti, M., Bastidas-Ponce, A., Baugé, E., Campbell, J. E., Capozzi, M., Clemmensen, C., Collden, G., Cota, P., Douros, J., Drucker, D. J., DuBois, B., Feuchtinger, A., Garcia-Caceres, C., Grandl, G. & 20 others, Hennuyer, N., Herzig, S., Hofmann, S. M., Knerr, P. J., Kulaj, K., Lalloyer, F., Lickert, H., Liskiewicz, A., Liskiewicz, D., Maity, G., Perez-Tilve, D., Prakash, S., Sanchez-Garrido, M. A., Zhang, Q., Staels, B., Krahmer, N., DiMarchi, R. D., Tschöp, M. H., Finan, B. & Müller, T. D., 2022, In: Nature Metabolism. 4, 8, p. 1071-1083 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

ADRA1A–Gα_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

Rahbani, J. F., Scholtes, C., Lagarde, D. M., Hussain, M. F., Roesler, A., Dykstra, C. B., Bunk, J., Samborska, B., O’Brien, S. L., Tripp, E., Pacis, A., Angueira, A. R., Johansen, O. S., Cinkornpumin, J., Hossain, I., Lynes, M. D., Zhang, Y., White, A. P., Pastor, W. A., Chondronikola, M. & 12 others, Sidossis, L., Klein, S., Kralli, A., Cypess, A. M., Pedersen, S. B., Jessen, N., Tseng, Y. H., Gerhart-Hines, Zach, Seale, P., Calebiro, D., Giguère, V. & Kazak, L., 2022, In: Nature Metabolism. 4, 11, p. 1459-1473

Research output: Contribution to journal › Letter › Research › peer-review

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D. & 32 others, Hilliard, A. T., Wang, Z., Xue, C., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Hwang, M. Y., Han, S., Zhao, J. H., Aadahl, Mette, Bork-Jensen, J., Møllehave, L. T., Liu, J., Wang, J., drb459, drb459, Jackson, R. D., Kovacs, P., Pedersen, Oluf Borbye, Hansen, Torben, Lind, L., Loos, Ruth, Christensen, K., Linneberg, Allan René, Grarup, Niels, Dantoft, T. M., Karpe, F., Wei, W. Q., Sun, Y. V., Million Veterans Program, M. V. P. & Global Lipids Genetics Consortium, G. L. G. C., 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The physiology of experimental overfeeding in animals

Ranea-Robles, Pablo, Lund, Jens & Clemmensen, Christoffer, 2022, In: Molecular Metabolism. 64, 15 p., 101573.

Research output: Contribution to journal › Review › Research › peer-review

Deciphering inhibitory activity of flavonoids against tau protein kinases: a coupled molecular docking and quantum chemical study

Rasouli, H., Hosseini Ghazvini, S. M. B., Yarani, R., Altıntaş, Ali, Jooneghani, S. G. N. & Ramalho, T. C., 2022, In: Journal of Biomolecular Structure & Dynamics. 40, 1, p. 411-424 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exome sequencing reveals the first intragenic deletion in ABCA5 underlying autosomal recessive hypertrichosis

Raza, R., Ullah, A., Haider, N., Krishin, J., Shah, M., Khan, F. U., Abdullah, Hansen, Torben, Raza, S. I., Ahmad, W. & Basit, S., 2022, In: Clinical and Experimental Dermatology. 47, 6, p. 1137-1143

Research output: Contribution to journal › Journal article › Research › peer-review

Jan Fahrenkrug (6/6 1947 – 10/11 2021)

Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.

Research output: Contribution to journal › Editorial › Research

The Liver-Alpha Cell Axis in Health and in Disease

Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861

Research output: Contribution to journal › Review › Research › peer-review

Causes of Outcome Learning: a causal inference-inspired machine learning approach to disentangling common combinations of potential causes of a health outcome

Rieckmann, Andreas, Dworzynski, P., Arras, L., Lapuschkin, S., Samek, W., Arah, O. A., Rod, Naja Hulvej & Ekstrøm, Claus Thorn, 2022, In: International Journal of Epidemiology. 51, 5, p. 1622–1636 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Amplicon sequencing demonstrates comparable follicular mycobiomes in patients with hidradenitis suppurativa compared with healthy controls

Ring, H. C., Thorsen, Jonathan Jan Ilve, Fuursted, K., Bjarnsholt, Thomas, Bay, Lene, Egeberg, Alexander, Ingham, Andreas, Vedel Nielsen, H., Frew, J. W., Saunte, Ditte Marie, Thomsen, Simon Francis & Jemec, Gregor, 2022, In: Journal of the European Academy of Dermatology and Venereology. 36, 7, p. e580-e583 4 p.

Research output: Contribution to journal › Comment/debate › Research