Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
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Impaired skeletal muscle regeneration in diabetes : From cellular and molecular mechanisms to novel treatments. / Espino-Gonzalez, Ever; Dalbram, Emilie; Mounier, Rémi; Gondin, Julien; Farup, Jean; Jessen, Niels; Treebak, Jonas T.
In: Cell Metabolism, 07.03.2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Impaired skeletal muscle regeneration in diabetes
T2 - From cellular and molecular mechanisms to novel treatments
AU - Espino-Gonzalez, Ever
AU - Dalbram, Emilie
AU - Mounier, Rémi
AU - Gondin, Julien
AU - Farup, Jean
AU - Jessen, Niels
AU - Treebak, Jonas T
N1 - Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2024/3/7
Y1 - 2024/3/7
N2 - Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.
AB - Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.
U2 - 10.1016/j.cmet.2024.02.014
DO - 10.1016/j.cmet.2024.02.014
M3 - Review
C2 - 38490209
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
ER -
ID: 386607465