TY - JOUR

T1 - Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring

AU - Crean, Angela Jane

AU - Senior, Alistair Mc Nair

AU - Freire, Therese

AU - Clark, Thomas Daniel

AU - Mackay, Flora

AU - Austin, Gracie

AU - Pulpitel, Tamara Jayne

AU - Nobrega, Marcelo Aguiar

AU - Barrès, Romain

AU - Simpson, Stephen James

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024

Y1 - 2024

N2 - Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-conception paternal dietary macronutrient balance on offspring metabolic and behavioral traits in mice. Ten isocaloric diets varying in the relative proportion of protein, fats, and carbohydrates are fed to male mice prior to mating. Dams and offspring are fed standard chow and never exposed to treatment diets. Body fat in female offspring is positively associated with the paternal consumption of fat, while in male offspring, an anxiety-like phenotype is associated to paternal diets low in protein and high in carbohydrates. Our study uncovers that the nature and the magnitude of paternal effects are driven by interactions between macronutrient balance and energy intake and are not solely the result of over- or undernutrition.

AB - Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-conception paternal dietary macronutrient balance on offspring metabolic and behavioral traits in mice. Ten isocaloric diets varying in the relative proportion of protein, fats, and carbohydrates are fed to male mice prior to mating. Dams and offspring are fed standard chow and never exposed to treatment diets. Body fat in female offspring is positively associated with the paternal consumption of fat, while in male offspring, an anxiety-like phenotype is associated to paternal diets low in protein and high in carbohydrates. Our study uncovers that the nature and the magnitude of paternal effects are driven by interactions between macronutrient balance and energy intake and are not solely the result of over- or undernutrition.

U2 - 10.1038/s41467-024-46782-y

DO - 10.1038/s41467-024-46782-y

M3 - Journal article

C2 - 38582785

AN - SCOPUS:85189887363

VL - 15

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2982

ER -