Holst Group – University of Copenhagen

Holst Group

Gut-Brain Signalling

The main research field of our group relates to the gut-brain axis. We find particularly interesting the peripheral and central role of the appetite stimulating, glucose regulatory hormone ghrelin in the control of various metabolic processes. 

Our group attempts to dissect the signal transduction mechanisms for different types of ligands together with related gut hormones acting on brain centres responsible for appetite and energy metabolism. 

We determine which signal transduction mechanisms translate into in vivo efficacy, and explore how the gut hormone receptor signalling interacts with other hormonal and central mechanisms. 

This relates not only to characterization of G protein pathways and classical second messenger systems, but also connections to previously unrecognized down-stream effectors in the target cell, such as hormone sensitive lipase (HSL).