Metabolism Day 2019

The purpose of Metabolism Day is to bring together researchers within the field of metabolism to discuss science. During the day, eight invited speakers will present current insights into metabolic diseases and energy control. The day will consist of talks and poster presentations, and will end with a buffet dinner and poster prizes. All researchers with an interest in metabolic research are welcome to attend the event.

Registration is closed.

Program for Metabolism Day, March 21, 2019

8:30-9:00
Registration
Coffee and set-up of posters
9:00-9:15
Welcome address
Executive Director, Professor Juleen R. Zierath, Novo Nordisk Foundation Center for Basic Metabolic Research
9:15-9:50
Regulatory Genetic Variants and Metabolic Diseases
Professor Marcelo Nobrega, University of Chicago, USA
Chair: Professor Romain Barrès
9:50-10:25
Akkermansia Muciniphila and Metabolic Disorders: From the Bench to the Bedside     
Professor Patrice Cani, UCLouvain, Belgium 
Chair: Associate Professor Manimozhiyan Arumugam
10:25-10:50
Coffee and Poster Presentations
Posters presented during this time slot: P01-P07 and P29-P35
10:50-11:25
The Enigma of Melanocortin-3 Receptor Function in Energy Homeostasis
Professor Roger Cone, University of Michigan, USA
Chair: Professor Thue W. Schwartz
11:25-12:00
Dietary and Neuroimmune Underpinnings of Mood Deficits in Obesity
Associate Professor Stephanie Fulton, Université de Montréal, Canada
Chair: Associate Professor Christoffer Clemmensen
12:00-13:00
Lunch
13:00-13:35
Metabolomics Applied for Discovery of Novel Cardiometabolic Disease Mechanisms
Professor Christopher Newgard, Duke University, USA
Chair: Professor Jens Juul Holst
13:35-14:10
Development and Role of Human Adipocyte Subtypes
Professor Silvia Corvera, University of Massachusetts Medical School, USA
Chair: Associate Professor Camilla Schéele
14:10-14:40
Coffee and Poster Presentations
Posters presented during this time slot: P08-P14 and P36-P42
14:40-15:15
Cardiometabolic Protective Mechanisms in the Burmese Python
Professor Leslie Leinwand, University of Colorado Boulder, USA
Chair: Professor Torben Hansen
15:15-15:50
Circadian Clock Genes and the Importance of Time in Metabolism and Longevity
Professor Joseph Takahashi, University of Texas Southwestern Medical Center, USA
Chair: Associate Professor Tune H. Pers
15:50-16:00
Closing remarks
Executive Director, Professor Juleen R. Zierath, Novo Nordisk Foundation Center for Basic Metabolic Research
16:00-17:00
Poster Presentations
Posters presented during this time slot: P15-P28 and P43-P57
17:30-18:30
Buffet Dinner
18:15
Poster Prizes

Presentation of speakers

Professor Patrice Cani

Professor Patrice D. Cani, PhD, senior researcher from the Belgian Fund for Scientific Research and Walloon Excellence Life sciences and Biotechnology (FNRS-WELBIO), team leader in the Metabolism and Nutrition research group at the Louvain Drug Research Institute (LDRI) from UCLouvain, Brussels, Belgium. In 2007, he published the discovery of the concept of metabolic endotoxemia, and more recently, he discovered the beneficial role of the bacteria Akkermansia muciniphila on obesity and cardiometabolic risk factors (published in PNAS 2013 and Nature Medicine 2017). His main research interests are the investigation of interactions between gut microbes, the host and specific biological systems including the endocannabinoid system and immunity in the context of obesity, type 2 diabetes, cardiometabolic disorders and cancer.

Professor Roger Cone

Professor Roger D. Cone, PhD, is Mary Sue Coleman Director for the Life Sciences Institute, and Vice Provost and Director for the Biosciences Initiative, both at the University of Michigan, USA. His studies on the melanocortin receptors have identified circuits in the brain, such as those characterized by the melanocortin-4 and melanocortin-3 receptors, that are critical for this process. Mutations in the melanocortin-4 receptor, in particular, are the most common cause of severe pediatric obesity. His laboratory concentrates on the central melanocortin system, a complex set of neural circuits they have demonstrated to regulate a variety of physiological processes important to energy storage.

Professor Silvia Corvera

Professor Silvia Corvera, MD, MSc, is Director for the Clinical Translational Research Pathway, Endowed Chair in Diabetes Research, and Co-Director for the MD/PhD program, University of Massachusetts Medical School, USA. She seeks to understand the basic physiopathology of type 2 diabetes, specifically the role of adipose tissue physiology in diabetes pathogenesis. The studies have contributed consistently to advancing knowledge in the field, beginning with the discovery of molecular mechanisms by which PI3-Kinase affects membrane trafficking in mammalian cells. Most recently, they have discovered a new approach to identify and produce human adipocytes from adult adipose tissue progenitors, including those corresponding to beige/brite adipocytes with high oxidative capacity. This approach makes it possible for the first time to generate, in-vitro, large amounts of human adipocytes that can be engrafted in humanized mice and affect systemic metabolism.

Associate Professor Stephanie Fulton

Stephanie Fulton, PhD, is member of the Montreal Diabetes Research Center and Associate Professor in the Department of Nutrition of the Université de Montreal, Canada. She obtained her doctoral degree in psychology and behavioural neurobiology at Concordia University in Montreal. Her graduate work led to the discovery that the adipose-derived hormone leptin modulates brain reward circuitry. Her laboratory uses animal models to investigate the neurometabolic and behavioural processes underlying motivation and emotional states. One line of study aims to identify brain mechanisms that give rise to the rewarding effects of palatable foods, compulsive eating and physical activity. Another focus of her lab is to uncover neurolipid and neuroimmune alterations in response to excess intake of different types of dietary fats and their impact on the development of mood disorders comorbid with obesity and diabetes.

Professor Leslie Leinwand

Professor Leslie Leinwand, PhD, is Co-Director for the Cardiovascular Institute, and Chief Scientific Officer for the BioFrontiers Institute, University of Colorado Boulder, USA. Her laboratory has worked to understand the mechanisms whereby heart and skeletal adapt to a wide variety of stimuli including sarcomeric protein mutations, myocardial infarction, exercise, and pregnancy. In each of these cases they also try to understand how biologic sex and diet modify these responses. Her laboratory has utilized the Burmese python as a model of extreme metabolic adaptation to large, infrequent meals and they hope to translate these findings to human disease.

Professor Christopher Newgard

Professor Christopher Newgard, PhD, is Director for the Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, USA. He is the founding Director of the Duke Molecular Physiology Institute. His research focuses on application of an interdisciplinary approach for understanding of cardiometabolic disease mechanisms involving gene discovery, metabolic engineering, and comprehensive tools of metabolic analysis (“metabolomics”) such as mass spectrometry-based metabolic profiling and metabolic flux analysis. Using these tools, he has identified novel mechanisms of interaction of branched-chain amino acid, lipid, and glucose metabolism and how these contribute to cardiometabolic disease pathogenesis. His group also works on pancreatic islet fuel sensing, with his most recent work focusing on the potential utility of pyruvate-isocitrate cycling intermediates for rescuing impaired secretory function in islets isolated from humans with type 2 diabetes.

Professor Marcelo Nobrega

Professor Marcelo Nobrega, MD, PhD, is a member of the Committee on Molecular Metabolism, University of Chicago, USA. By using genomics technologies to address how noncoding variations lead to phenotypic variation, he has pursued noncoding GWAS hits, establishing strategies for the identificiation of long-range regulatory elements and the demonstration that genetic variation within these regulatory units often underlies the association signals emerging from GWAS. He utilizes comparative genomics approaches to identify functional enhancers in gene poor regions of the genome, dubbed gene deserts. He demonstrated that deletions of genomic regions containing large numbers of functional enhancers may lead to minimal phenotypic impact.

Professor Joseph Takahashi

Professor Joseph S. Takahashi, PhD, is the Loyd B. Sands Distinguished Chair in Neuroscience, Investigator at the Howard Hughes Medical Institute, and Chair of the Department of Neuroscience, University of Texas Southwestern Medical Center, USA. His research interests are the molecular mechanism of circadian clocks, neuroscience, and the genetic basis of behavior. He pioneered the use of forward genetics and positional cloning in the mouse as a tool for discovery of genes underlying neurobiology and behavior, and his discovery of the mouse and human Clock genes led to a description of a conserved circadian clock mechanism in animals.

General
Participants will receive an abstract book with all abstracts at Metabolism Day.
You are expected to present your poster during Metabolism Day. You will be informed of the timeslot of your presentation in advance.

The size of the posters boards are 115 cm (width) x 160 cm (height) (~45 x 63 inches).