Metabolism Month – An online conference about energy control and metabolism
Metabolism Month brings together researchers within the field of metabolism to discuss the latest science in metabolic diseases and energy control. It is hosted and organised by the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen.
For Metabolism Month 2021 – which was held on March 2, 9, 16 and 23 – CBMR organised eight internationally-recognised speakers, three poster sessions and an open session with CBMR's PIs. The format was the same for each day: Two speakers with a poster session or debate in between, from 16:00 to 18:00 CET.
Each day had a different theme, which corresponded to CBMR's four research programs.
The conference attracted over 1,600 registered attendees over the course of the month, drawn from more than 45 countries around the world.
'Metabolic Control of the Molecular Clock'
Dr. Joseph Bass is the Charles F Kettering Professor of Medicine, and the Chief of the Division of Endocrinology, Metabolism and Molecular Medicine at Northwestern University.
Joseph Bass established links between molecular clocks and metabolism that have been at the forefront of studies of circadian biomedicine. He made the original discovery that disruption of the core molecular circadian clock leads to desynchrony between feeding and sleep cycles and promotes obesity, demonstrating that clock genes are essential for glucose and body weight homeostasis. He subsequently demonstrated that cellular clocks control hunger, insulin secretion, and mitochondrial function, and that an obesogenic diet dissociates clock cycles from the environment, revealing that circadian timing governs metabolic health. He also showed that the circadian clock regulates nucleotide metabolism, in turn modulating day/night cycles of mitochondrial respiration and exercise capacity.
Active as both an endocrinologist and investigator, Bass has opened up a new field that is illuminating how molecular clocks control physiology at different times of day, with a broad range of medical implications including new avenues for treating diabetes and obesity.
The four poster sessions offer young scientists the opportunity to present their work to a wider audience. They will take place between the two lectures, 16:45-17:15.
If you want to present a poster, simply select the option when you register. Please pick a day with a theme that fits your presentation.
You don't have to upload a poster and abstract when you register. When you register you will receive a confirmation email with a link to your registration. Just follow the link and update your registration with the abstract and poster when you are ready.
Posters and abstracts must be uploaded latest ten days before your presentation
'Adipose Tissue – Therapeutic target for Diabetes'
Philipp Scherer is Professor and Director of the Touchstone Diabetes Center at the University of Texas Southwestern Medical Center in Dallas. He received his Ph.D. degree from the University of Basel, Switzerland, followed by post-doctoral training the Whitehead Institute at MIT in Cambridge. In 1997, he joined the faculty of the Albert Einstein College of Medicine where he was a Professor for Cell Biology and Medicine. Throughout his career, he has maintained an interest in processes related to cellular and systemic energy homeostasis. He identified adiponectin, one of the first secretory factors to be described that almost exclusively originate in adipose tissue and which is currently widely studied by many different research groups.
Current efforts in his laboratory are focused on the identification and physiological characterization of novel proteins that serve as potential links between the adipocyte, liver, the pancreatic beta cell and the processes of whole body energy homeostasis, inflammation, cancer and cardiovascular disease.
Scherer has been on the faculty of UT Southwestern Medical Center since 2007 as a member of the Department of Internal Medicine. He holds the Touchstone Distinguished Chair in Diabetes Research and is a member of the Simmons Comprehensive Cancer Center. He was awarded the 2015 Banting Medal for Scientific Achievement from the American Diabetes Association, the 2017 European Association for the Study of Diabetes (EASD) / Novo Nordisk Foundation Diabetes Prize for Excellence and the 2018 Manpei Suzuki Prize in Japan.
'The Genetics of Obesity – From genes, to biology, … to clinical practice'
Ruth Loos is the director of the Genetics of Obesity and Related Metabolic Traits Program, and co-director of The Charles Bronfman Institute of Personalized Medicine at the Icahn School of Medicine at Mount Sinai.
Her research focuses on the etiology of obesity, in particular, on the identification of genes and genetic loci contributing to the risk of obesity and related traits. She has been involved in gene-discovery since 2005. With the GIANT (Genetic Investigation of ANTropometric traits) consortium, she has contributed to the majority of large-scale gene-discovery efforts that thus far have revealed more than 1,000 obesity-associated loci. Furthermore, she studies more refined adiposity phenotypes and biomarkers related to body shape and fat distribution to reveal new biology that has not been uncovered by using traditional obesity outcomes.
Besides gene-discovery, Ruth uses epidemiological methods to assess the public health implications of the established loci by examining their predictive value, interaction with lifestyle factors, and their role in precision medicine of common obesity.
'The Genetics of Exercise Adherence and Response'
Dr. Bray holds the Susan T. Jastrow Endowed Chair in the Department of Nutritional Sciences at the University of Texas at Austin, with a master’s degree in Exercise Physiology and a PhD in Human and Molecular Genetics.
Dr. Bray’s research focuses on the relationship between genetic variation, energy balance, and lifestyle factors such as exercise, nutrition, and circadian patterns of behavior. Work in her laboratory is designed to identify the mechanisms by which timing and quality of energy intake affects weight gain and metabolic health, in particular through intestinal absorption and the gut microbiome.
Dr. Bray also currently leads one of the largest genetic studies of exercise adherence established to date, the Training Interventions and Genetics of Exercise Response (TIGER) study, with a total cohort of more than 3,500 individuals. Dr. Bray’s research has included investigations of aerobic fitness and resting and exercise energy expenditure in children and adolescents and clinical studies of morbidly obese adolescents undergoing bariatric surgery.
'Programming of Cardio-Metabolic Health by Maternal Obesity: A Developing Crisis'
'The CNS Control of Metabolism'
'Big Data and Health'
Michael Snyder is the Stanford Ascherman Professor and Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine. Dr. Snyder received his Ph.D. training at the California Institute of Technology and carried out postdoctoral training at Stanford University. He is a leader in the field of functional genomics and multiomics, and one of the major participants of the ENCODE project. His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has developed many technologies in genomics and proteomics. These including the development of proteome chips, high resolution tiling arrays for the entire human genome, methods for global mapping of transcription factor (TF) binding sites (ChIP-chip now replaced by ChIP-seq), paired end sequencing for mapping of structural variation in eukaryotes, de novo genome sequencing of genomes using high throughput technologies and RNA-Seq. These technologies have been used for characterizing genomes, proteomes and regulatory networks. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated (e.g. lncRNAs and TF binding sites), and a high diversity of transcription factor binding occurs both between and within species. He has also combined different state-of–the-art “omics” technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He is a cofounder of many biotechnology companies, including Excelix, Personalis, SensOmics, Qbio, January, Mirvie and Filtricine.
On March 23, we will host a live session with 12 of CBMR's PIs. Find the PIs at their own virtual tables in the Lounge area where you can ask questions, discuss science and learn more about their research.
'Metabolism and Society: A Short History of Mutual Transformation’
Hannah Landecker holds a joint appointment in the life and social sciences at UCLA, where she is a Professor in the Department of Sociology, and Director of the Institute for Society and Genetics. The Institute for Society and Genetics is an interdisciplinary unit at UCLA committed to cultivating research and pedagogy at the interface of the life and human sciences, and houses the Human Biology and Society undergraduate major. She also recently helped found the UCLA EpiCenter for interdisciplinary study of the intersection of reproduction, epigenetics, and society, and is its co-director; she is a senior editor of the journal BioSocieties.
Landecker, a historian and sociologist of science, studied cell and developmental biology before going on to receive her PhD in Science and Technology Studies from MIT. She is the author of Culturing Life: How Cells Became Technologies (Harvard UP, 2007), as well as many research articles spanning topics from the development of time-lapse microcinematography to the environmental politics of reproduction. Her current research interests have turned toward the history and social study of metabolism and epigenetics, and this talk is drawn from her current book project, American Metabolism.