Bäckhed Group

  1. 2021
  2. Published

    A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

    Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, Siv Annegrethe, Nielsen, J., Schwartz, Thue W., Groen, A. K., Nieuwdorp, M., Bäckhed, Gert Fredrik & Gerdes, V. E. A., 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice

    Ratner, Cecilia Friis, Shin, J. H., Dwibedi, C., Tremaroli, V., Bjerregaard, A., Hartmann, Bolette, Bäckhed, Gert Fredrik, Leinninger, G., Seeley, R. J. & Holst, Birgitte, 2021, In: Endocrinology. 162, 9, 12 p., bqab130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

    Bui, T. P. N., Mannerås-Holm, L., Puschmann, R., Wu, H., Troise, A. D., Nijsse, B., Boeren, S., Bäckhed, Gert Fredrik, Fiedler, D. & deVos, W. M., 2021, In: Nature Communications. 12, 1, 16 p., 4798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

    Roswall, J., Olsson, L. M., Kovatcheva-Datchary, P., Nilsson, S., Tremaroli, V., Simon, M., Kiilerich, P., Akrami, R., Kramer, M., Uhlen, M., Gummesson, A., Kristiansen, Karsten, Dahlgren, J. & Bäckhed, Gert Fredrik, 2021, In: Cell Host & Microbe. 29, 5, p. 765-776.e3 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

    Baumgartner, R., Casagrande, F. B., Mikkelsen, Randi Bonke, Berg, M., Polyzos, K. A., Forteza, M. J., Arora, A., Schwartz, Thue W., Hjorth, Siv Annegrethe & Ketelhuth, D. F. J., 2021, In: Metabolites. 11, 7, 10 p., 411.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

    Choi, B. S., Daniel, N., Houde, V. P., Ouellette, A., Marcotte, B., Varin, T. V., Vors, C., Feutry, P., Ilkayeva, O., Stahlman, M., St-Pierre, P., Bäckhed, Gert Fredrik, Tremblay, A., White, P. J. & Marette, A., 2021, In: Nature Communications. 12, 16 p., 3377.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Gut microbial metabolites as multi-kingdom intermediates

    Krautkramer, K. A., Fan, J. & Bäckhed, Gert Fredrik, 2021, In: Nature Reviews. Microbiology. 19, p. 77-94 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Leaky Gut as a Potential Culprit for the Paradoxical Dysglycemic Response to Gastric Bypass-Associated Ileal Microbiota

    Hankir, M. K., Seyfried, F., Schellinger, I. N., Schlegel, N. & Arora, Tulika, 2021, In: Metabolites. 11, 3, 10 p., 153.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes

    Gummesson, A., Björnson, E., Fagerberg, L., Zhong, W., Tebani, A., Edfors, F., Schmidt, C., Lundqvist, A., Adiels, M., Bäckhed, Gert Fredrik, Schwenk, J. M., Jansson, P. A., Uhlén, M. & Bergström, G., 2021, In: EBioMedicine. 63, 11 p., 103147.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice

    Zhang, X. S., Yin, Y. S., Wang, J., Battaglia, T., Krautkramer, K., Li, W. V., Li, J., Brown, M., Zhang, M., Badri, M. H., Armstrong, A. J. S., Strauch, C. M., Wang, Z., Nemet, I., Altomare, N., Devlin, J. C., He, L., Morton, J. T., Chalk, J. A., Needles, K., Liao, V., Mount, J., Li, H., Ruggles, K. V., Bonneau, R. A., Dominguez-Bello, M. G., Bäckhed, Gert Fredrik, Hazen, S. L. & Blaser, M. J., 2021, In: Cell Host and Microbe. 29, 8, p. 1249-1265.e9

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Microbial regulation of enteroendocrine cells

    Arora, Tulika, Vanslette, A. M., Hjorth, Siv Annegrethe & Bäckhed, Gert Fredrik, 2021, In: Med. 2, 5, p. 553-570 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese Humans

    van Son, J., Serlie, M. J., Stahlman, M., Bäckhed, Gert Fredrik, Nieuwdorp, M. & Aron-Wisnewsky, J., 2021, In: Nutrients. 13, 8, 8 p., 2706.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

    Castellanos-Jankiewicz, A., Guzman-Quevedo, O., Fenelon, V. S., Zizzari, P., Quarta, C., Bellocchio, L., Tailleux, A., Charton, J., Fernandois, D., Henricsson, M., Piveteau, C., Simon, V., Allard, C., Quemener, S., Guinot, V., Hennuyer, N., Perino, A., Duveau, A., Maitre, M., Leste-Lasserre, T., Clark, S., Dupuy, N., Cannich, A., Gonzales, D., Deprez, B., Mithieux, G., Dombrowicz, D., Bäckhed, Gert Fredrik, Prevot, V., Marsicano, G., Staels, B., Schoonjans, K. & Cota, D., 2021, In: Cell Metabolism. 33, 7, p. 1483-1492.e1-e10 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

    Venskutonytė, R., Koh, A., Stenström, O., Khan, M. T., Lundqvist, A., Akke, M., Bäckhed, Gert Fredrik & Lindkvist-Petersson, K., 2021, In: Nature Communications. 12, 1, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism

    Heiss, C. N., Mannerås-Holm, L., Lee, Y. S., Serrano-Lobo, J., Håkansson Gladh, A., Seeley, R. J., Drucker, D. J., Bäckhed, Gert Fredrik & Olofsson, L. E., 2021, In: Cell Reports. 35, 8, 16 p., 109163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes

    Arora, Tulika & Tremaroli, V., 2021, In: Frontiers in Endocrinology. 12, 10 p., 761834.

    Research output: Contribution to journalReviewResearchpeer-review

  18. 2020
  19. Published

    L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

    Lund, M. L., Sorrentino, G., Egerod, Kristoffer Lihme, Kroone, C., Mortensen, B., Knop, Filip Krag, Reimann, F., Gribble, F. M., Drucker, D. J., De Koning, E. J. P., Schoonjans, K., Bäckhed, Gert Fredrik, Schwartz, Thue W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice

    Simon, M., Reinbeck, A. L., Wessel, C., Heindirk, J., Jelenik, T., Kaul, K., Arreguin-Cano, J., Strom, A., Blaut, M., Bäckhed, Gert Fredrik, Burkart, V. & Roden, M., 2020, In: Journal of Biological Chemistry. 295, 4, p. 969-980 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Distinct differences in gut microbial composition and functional potential from lean to morbidly obese subjects

    Meijnikman, A. S., Aydin, O., Prodan, A., Tremaroli, V., Herrema, H., Levin, E., Acherman, Y., Bruin, S., Gerdes, V. E., Bäckhed, Gert Fredrik, Groen, A. K. & Nieuwdorp, M., 2020, In: Journal of Internal Medicine. 288, 6, p. 699-710

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study

    Djekic, D., Shi, L., Brolin, H., Carlsson, F., Sarnqvist, C., Savolainen, O., Cao, Y., Bäckhed, Gert Fredrik, Tremaroli, V., Landberg, R. & Frobert, O., 2020, In: Journal of the American Heart Association. 9, 18, 75 p., 016518.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism

    Koh, A. & Bäckhed, Gert Fredrik, 2020, In: Molecular Cell. 78, 4, p. 584-596

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health

    Olsson, L. M., Poitou, C., Tremaroli, V., Coupaye, M., Aron-Wisnewsky, J., Bäckhed, Gert Fredrik, Clément, K. & Caesar, R., 2020, In: Gut. 69, 7, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Hepatic expression of lipopolysaccharide- binding protein ( Lbp ) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

    Molinaro, A., Koh, A., Wu, H., Schoeler, M., Faggi, M. I., Carreras, A., Hallen, A., Bäckhed, Gert Fredrik & Caesar, R., 2020, In: Molecular Metabolism. 37, 9 p., 100997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

    Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, Trine, Bergh, P., Rouault, C., Andre, S., Marquet, F., Andreelli, F., Salem, J., Assmann, K., Bastard, J., Forslund, S., Le Chatelier, E., Falony, G., Pons, N., Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T. H., Pedersen, Helle Krogh, Lewinter, C., Sønderskov, N. B., Køber, Lars Valeur, Vestergaard, H., Hansen, Torben, Zucker, J., Galan, P., Dumas, M., Raes, J., Oppert, J., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S. D., Stumvoll, M., Pedersen, Oluf Borbye, Aron-Wisneswky, J., Clement, K., Bäckhed, Gert Fredrik & MetaCardis Consortium, M. C., 2020, In: Nature Communications. 11, 1, 10 p., 5881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

    Koh, A., Manneras-Holm, L., Yunn, N., Nilsson, P. M., Ryu, S. H., Molinaro, A., Perkins, R., Smith, J. G. & Bäckhed, Gert Fredrik, 2020, In: Cell Metabolism. 32, 4, p. 643-653.e4 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
  29. Published

    Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

    Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C. & Bäckhed, Gert Fredrik, 2020, In: Journal of Biological Chemistry. 295, 46, p. 15712-15726 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR

    Hankir, M. K., Langseder, T., Bankoglu, E. E., Ghoreishi, Y., Dischinger, U., Kurlbaum, M., Kroiss, M., Otto, C., le Roux, C. W., Arora, Tulika, Seyfried, F. & Schlegel, N., 2020, In: iScience. 23, 12, 32 p., 101777.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

    Vieira-Silva, S., Falony, G., Belda, E., Nielsen, Trine, Aron-Wisnewsky, J., Chakaroun, R., Forslund, S. K., Assmann, K., Valles-Colomer, M., Nguyen, T. T. D., Proost, S., Prifti, E., Tremaroli, V., Pons, N., Le Chatelier, E., Andreelli, F., Bastard, J., Coelho, L. P., Galleron, N., Hansen, T. H., Hulot, J., Lewinter, C., Pedersen, Helle Krogh, Quinquis, B., Rouault, C., Roume, H., Salem, J., Søndertoft, Nadja Buus, Touch, S., Dumas, M., Ehrlich, S. D., Galan, P., Gøtze, J. P., Hansen, Torben, Holst, Jens Juul, Køber, Lars Valeur, Letunic, I., Nielsen, J., Oppert, J., Stumvoll, M., Vestergaard, H., Zucker, J., Bork, P., Pedersen, Oluf Borbye, Bäckhed, Gert Fredrik, Clément, K., Raes, J. & MetaCardis Consortium, M. C., 2020, In: Nature. 581, 7808, p. 310-315

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study

    Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Kramer, M., Gummesson, A., Perkins, R., Bergstrom, G. & Bäckhed, Gert Fredrik, 2020, In: Cell Metabolism. 32, 3, p. 379-390.e3 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2019
  34. Published

    Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity

    Arora, Tulika, Rudenko, Olga, Egerod, Kristoffer Lihme, Husted, Anna Sofie, Kovatcheva-Datchary, P., Akrami, R., Kristensen, M., Schwartz, Thue W. & Bäckhed, Gert Fredrik, Mar 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 3, p. E453-E463

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics

    Sandberg, J., Kovatcheva-datchary, P., Björck, I., Bäckhed, Gert Fredrik & Nilsson, A., 2019, In: European Journal of Nutrition. 58, 6, p. 2365-2376

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice

    Poupeau, A., Garde, C., Sulek, Karolina, Citirikkaya, K., Treebak, Jonas Thue, Arumugam, Mani, Simar, D., Olofsson, L. E., Bäckhed, Gert Fredrik & Barrès, Romain, 2019, In: F A S E B Journal. 33, 2, p. 2719-2731 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

    Molinaro, A., Becattini, B., Mazzoli, A., Bleve, A., Radici, L., Maxvall, I., Sopasakis, V. R., Molinaro, A., Bäckhed, Gert Fredrik & Solinas, G., 2019, In: Cell Metabolism. 29, 6, p. 1400-1409.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review

    Tang, W. H. W., Bäckhed, Gert Fredrik, Landmesser, U. & Hazen, S. L., 2019, In: Journal of the American College of Cardiology. 73, 16, p. 2089-2105

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding

    Molinaro, A., Caesar, R., L'homme, L., Koh, A., Stahlman, M., Staels, B. & Bäckhed, Gert Fredrik, 2019, In: Molecular Metabolism. 23, p. 82-87 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model

    Kovatcheva-Datchary, P., Shoaie, S., Lee, S., Wahlstrom, A., Nookaew, I., Hallen, A., Perkins, R., Nielsen, J. & Bäckhed, Gert Fredrik, 2019, In: Cell Reports. 26, 13, p. 3772-3783.e6 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    The next decade of metabolism

    Bäckhed, Gert Fredrik, Bugianesi, E., Christofk, H., Dikic, I., Gupta, R., Mair, W. B., O'Neill, L. A. J., Ralser, M., Sabatini, D. M. & Tschop, M., 2019, In: Nature Metabolism. 1, p. 2-4

    Research output: Contribution to journalComment/debateResearch