Extreme duration exercise affects old and younger men differently

Research output: Contribution to journalJournal articlepeer-review

Standard

Extreme duration exercise affects old and younger men differently. / Frandsen, Jacob; Sahl, Ronni Eg; Rømer, Tue; Thunestvedt Hansen, Mikkel; Nielsen, Andreas Blaaholm; Lie-Olesen, Michelle Munk; Rasmusen, Hanne Kruuse; Søgaard, Ditte; Ingersen, Arthur; Rosenkilde, Mads; Westerterp, Klaas; Holst, Jens Juul; Andersen, Jesper Løvind; Markowski, Adam Roman; Blachnio-Zabielska, Agnieszka; Clemmensen, Christoffer; Sacchetti, Massimo; Cataldo, Angelo; Traina, Marcello; Larsen, Steen; Dela, Flemming; Helge, Jørn Wulff.

In: Acta Physiologica, Vol. 235, No. 3, e13816, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Frandsen, J, Sahl, RE, Rømer, T, Thunestvedt Hansen, M, Nielsen, AB, Lie-Olesen, MM, Rasmusen, HK, Søgaard, D, Ingersen, A, Rosenkilde, M, Westerterp, K, Holst, JJ, Andersen, JL, Markowski, AR, Blachnio-Zabielska, A, Clemmensen, C, Sacchetti, M, Cataldo, A, Traina, M, Larsen, S, Dela, F & Helge, JW 2022, 'Extreme duration exercise affects old and younger men differently', Acta Physiologica, vol. 235, no. 3, e13816. https://doi.org/10.1111/apha.13816

APA

Frandsen, J., Sahl, R. E., Rømer, T., Thunestvedt Hansen, M., Nielsen, A. B., Lie-Olesen, M. M., Rasmusen, H. K., Søgaard, D., Ingersen, A., Rosenkilde, M., Westerterp, K., Holst, J. J., Andersen, J. L., Markowski, A. R., Blachnio-Zabielska, A., Clemmensen, C., Sacchetti, M., Cataldo, A., Traina, M., ... Helge, J. W. (2022). Extreme duration exercise affects old and younger men differently. Acta Physiologica, 235(3), [e13816]. https://doi.org/10.1111/apha.13816

Vancouver

Frandsen J, Sahl RE, Rømer T, Thunestvedt Hansen M, Nielsen AB, Lie-Olesen MM et al. Extreme duration exercise affects old and younger men differently. Acta Physiologica. 2022;235(3). e13816. https://doi.org/10.1111/apha.13816

Author

Frandsen, Jacob ; Sahl, Ronni Eg ; Rømer, Tue ; Thunestvedt Hansen, Mikkel ; Nielsen, Andreas Blaaholm ; Lie-Olesen, Michelle Munk ; Rasmusen, Hanne Kruuse ; Søgaard, Ditte ; Ingersen, Arthur ; Rosenkilde, Mads ; Westerterp, Klaas ; Holst, Jens Juul ; Andersen, Jesper Løvind ; Markowski, Adam Roman ; Blachnio-Zabielska, Agnieszka ; Clemmensen, Christoffer ; Sacchetti, Massimo ; Cataldo, Angelo ; Traina, Marcello ; Larsen, Steen ; Dela, Flemming ; Helge, Jørn Wulff. / Extreme duration exercise affects old and younger men differently. In: Acta Physiologica. 2022 ; Vol. 235, No. 3.

Bibtex

@article{2aa7904652234ff0bc70548b394abaa0,
title = "Extreme duration exercise affects old and younger men differently",
abstract = "AIM & METHODS: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30±5 years or age 65±6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days.RESULTS: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. {\.V}O 2 max did not change in younger cyclists, but decreased (p=0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. CONCLUSION: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.",
author = "Jacob Frandsen and Sahl, {Ronni Eg} and Tue R{\o}mer and {Thunestvedt Hansen}, Mikkel and Nielsen, {Andreas Blaaholm} and Lie-Olesen, {Michelle Munk} and Rasmusen, {Hanne Kruuse} and Ditte S{\o}gaard and Arthur Ingersen and Mads Rosenkilde and Klaas Westerterp and Holst, {Jens Juul} and Andersen, {Jesper L{\o}vind} and Markowski, {Adam Roman} and Agnieszka Blachnio-Zabielska and Christoffer Clemmensen and Massimo Sacchetti and Angelo Cataldo and Marcello Traina and Steen Larsen and Flemming Dela and Helge, {J{\o}rn Wulff}",
note = "This article is protected by copyright. All rights reserved.",
year = "2022",
doi = "10.1111/apha.13816",
language = "English",
volume = "235",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Extreme duration exercise affects old and younger men differently

AU - Frandsen, Jacob

AU - Sahl, Ronni Eg

AU - Rømer, Tue

AU - Thunestvedt Hansen, Mikkel

AU - Nielsen, Andreas Blaaholm

AU - Lie-Olesen, Michelle Munk

AU - Rasmusen, Hanne Kruuse

AU - Søgaard, Ditte

AU - Ingersen, Arthur

AU - Rosenkilde, Mads

AU - Westerterp, Klaas

AU - Holst, Jens Juul

AU - Andersen, Jesper Løvind

AU - Markowski, Adam Roman

AU - Blachnio-Zabielska, Agnieszka

AU - Clemmensen, Christoffer

AU - Sacchetti, Massimo

AU - Cataldo, Angelo

AU - Traina, Marcello

AU - Larsen, Steen

AU - Dela, Flemming

AU - Helge, Jørn Wulff

N1 - This article is protected by copyright. All rights reserved.

PY - 2022

Y1 - 2022

N2 - AIM & METHODS: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30±5 years or age 65±6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days.RESULTS: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. V̇O 2 max did not change in younger cyclists, but decreased (p=0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. CONCLUSION: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.

AB - AIM & METHODS: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30±5 years or age 65±6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days.RESULTS: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. V̇O 2 max did not change in younger cyclists, but decreased (p=0.06) in the older cohort. The resting plasma FFA concentration decreased markedly in both groups, and plasma glucose increased in the younger group. In the older cohort, plasma LDL-cholesterol and plasma triglyceride decreased. In skeletal muscle, fat transporters CD36 and FABPm remained unchanged. The glucose handling proteins GLUT4 and SNAP23 increased in both groups. Mitochondrial ROS production decreased in both groups and ADP sensitivity increased in skeletal muscle in the older but not in the younger cohort. CONCLUSION: In summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.

U2 - 10.1111/apha.13816

DO - 10.1111/apha.13816

M3 - Journal article

C2 - 35347845

VL - 235

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 3

M1 - e13816

ER -

ID: 302202552