Muscarinic receptors in energy homeostasis: Physiology and pharmacology
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Muscarinic receptors in energy homeostasis : Physiology and pharmacology. / Falk, Sarah; Lund, Camilla; Clemmensen, Christoffer.
In: Basic & Clinical Pharmacology & Toxicology, Vol. 126, No. Suppl. 6, 2020, p. 66-76.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Muscarinic receptors in energy homeostasis
T2 - GPCR Pharmacology
AU - Falk, Sarah
AU - Lund, Camilla
AU - Clemmensen, Christoffer
N1 - Special Issue: MiniReviews and Original Articles from the BCPT‐sponsored Focused Nordic Conference “GPCR Pharmacology – The Next Generation”, held in Copenhagen, Denmark, 31
PY - 2020
Y1 - 2020
N2 - Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significant weight loss must combat powerful counter‐regulatory energy homeostatic processes, and, typically, most individuals regain the lost weight. Therefore, decoding the neural mechanisms underlying the regulation of energy homeostasis is necessary for developing breakthroughs in obesity management. It has been known for decades that cholinergic neurotransmission both directly and indirectly modulates energy homeostasis and metabolic health. Despite this insight, the molecular details underlying the modulation remain ill‐defined, and the potential for targeting cholinergic muscarinic receptors for treating metabolic disease is largely uncharted. In this MiniReview, we scrutinize the literature that has formed our knowledge of muscarinic acetylcholine receptors (mAChRs) in energy homeostasis. The role of mAChRs in canonical appetite‐regulating circuits will be discussed as will the more indirect regulation of energy homoeostasis via neurocircuits linked to motivated behaviours and emotional states. Finally, we discuss the therapeutic prospects of targeting mAChRs for the treatment of obesity and type 2 diabetes.
AB - Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significant weight loss must combat powerful counter‐regulatory energy homeostatic processes, and, typically, most individuals regain the lost weight. Therefore, decoding the neural mechanisms underlying the regulation of energy homeostasis is necessary for developing breakthroughs in obesity management. It has been known for decades that cholinergic neurotransmission both directly and indirectly modulates energy homeostasis and metabolic health. Despite this insight, the molecular details underlying the modulation remain ill‐defined, and the potential for targeting cholinergic muscarinic receptors for treating metabolic disease is largely uncharted. In this MiniReview, we scrutinize the literature that has formed our knowledge of muscarinic acetylcholine receptors (mAChRs) in energy homeostasis. The role of mAChRs in canonical appetite‐regulating circuits will be discussed as will the more indirect regulation of energy homoeostasis via neurocircuits linked to motivated behaviours and emotional states. Finally, we discuss the therapeutic prospects of targeting mAChRs for the treatment of obesity and type 2 diabetes.
U2 - 10.1111/bcpt.13311
DO - 10.1111/bcpt.13311
M3 - Review
C2 - 31464050
VL - 126
SP - 66
EP - 76
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - Suppl. 6
Y2 - 31 October 2018 through 2 November 2018
ER -
ID: 228150374