Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans

Research output: Contribution to journal › Journal article › peer-review

Standard

Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans. / Morville, Thomas; Sahl, Ronni E.; Moritz, Thomas; Helge, Jørn W.; Clemmensen, Christoffer.

In: Cell Reports, Vol. 33, No. 13, 108554, 2020.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Morville, T, Sahl, RE, Moritz, T, Helge, JW & Clemmensen, C 2020, 'Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans', Cell Reports, vol. 33, no. 13, 108554. https://doi.org/10.1016/j.celrep.2020.108554

APA

Morville, T., Sahl, R. E., Moritz, T., Helge, J. W., & Clemmensen, C. (2020). Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans. Cell Reports, 33(13), [108554]. https://doi.org/10.1016/j.celrep.2020.108554

Vancouver

Morville T, Sahl RE, Moritz T, Helge JW, Clemmensen C. Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans. Cell Reports. 2020;33(13). 108554. https://doi.org/10.1016/j.celrep.2020.108554

Author

Morville, Thomas ; Sahl, Ronni E. ; Moritz, Thomas ; Helge, Jørn W. ; Clemmensen, Christoffer. / Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans. In: Cell Reports. 2020 ; Vol. 33, No. 13.

Bibtex

@article{ea9838618e7e4ada83500503ad4bb4c9,
title = "Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans",
abstract = "The mechanisms by which exercise benefits human health remain incompletely understood. With the emergence of omics techniques, mapping of the molecular response to exercise is increasingly accessible. Here, we perform an untargeted metabolomics profiling of plasma from a randomized, within-subjects, crossover study of either endurance exercise or resistance exercise, two types of skeletal muscle activity that have differential effects on human physiology. A high-resolution time-series analyses reveal shared as well as exercise-mode-specific perturbations in a multitude of metabolic pathways. Moreover, the analyses reveal exercise-induced changes in metabolites that are recognized to act as signaling molecules. Thus, we provide a metabolomic signature of how dissimilar modes of exercise affect the organism in a time-resolved fashion.",
keywords = "ACID, ACYLCARNITINES, OXIDATION, STRESS",
author = "Thomas Morville and Sahl, {Ronni E.} and Thomas Moritz and Helge, {J{\o}rn W.} and Christoffer Clemmensen",
year = "2020",
doi = "10.1016/j.celrep.2020.108554",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",

}

RIS

TY - JOUR

T1 - Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans

AU - Morville, Thomas

AU - Sahl, Ronni E.

AU - Moritz, Thomas

AU - Helge, Jørn W.

AU - Clemmensen, Christoffer

PY - 2020

Y1 - 2020

N2 - The mechanisms by which exercise benefits human health remain incompletely understood. With the emergence of omics techniques, mapping of the molecular response to exercise is increasingly accessible. Here, we perform an untargeted metabolomics profiling of plasma from a randomized, within-subjects, crossover study of either endurance exercise or resistance exercise, two types of skeletal muscle activity that have differential effects on human physiology. A high-resolution time-series analyses reveal shared as well as exercise-mode-specific perturbations in a multitude of metabolic pathways. Moreover, the analyses reveal exercise-induced changes in metabolites that are recognized to act as signaling molecules. Thus, we provide a metabolomic signature of how dissimilar modes of exercise affect the organism in a time-resolved fashion.

AB - The mechanisms by which exercise benefits human health remain incompletely understood. With the emergence of omics techniques, mapping of the molecular response to exercise is increasingly accessible. Here, we perform an untargeted metabolomics profiling of plasma from a randomized, within-subjects, crossover study of either endurance exercise or resistance exercise, two types of skeletal muscle activity that have differential effects on human physiology. A high-resolution time-series analyses reveal shared as well as exercise-mode-specific perturbations in a multitude of metabolic pathways. Moreover, the analyses reveal exercise-induced changes in metabolites that are recognized to act as signaling molecules. Thus, we provide a metabolomic signature of how dissimilar modes of exercise affect the organism in a time-resolved fashion.

KW - ACID

KW - ACYLCARNITINES

KW - OXIDATION

KW - STRESS

U2 - 10.1016/j.celrep.2020.108554

DO - 10.1016/j.celrep.2020.108554

M3 - Journal article

C2 - 33378671

VL - 33

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 13

M1 - 108554

ER -

ID: 255681414