High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle. / Hostrup, Morten; Lemminger, Anders Krogh; Stocks, Ben; Gonzalez-Franquesa, Alba; Larsen, Jeppe Kjærgaard; Quesada, Julia Prats; Thomassen, Martin; Weinert, Brian Tate; Bangsbo, Jens; Deshmukh, Atul Shahaji.

In: eLife, Vol. 11, 69802, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hostrup, M, Lemminger, AK, Stocks, B, Gonzalez-Franquesa, A, Larsen, JK, Quesada, JP, Thomassen, M, Weinert, BT, Bangsbo, J & Deshmukh, AS 2022, 'High-intensity interval training remodels the proteome and acetylome of human skeletal muscle', eLife, vol. 11, 69802. https://doi.org/10.7554/eLife.69802

APA

Hostrup, M., Lemminger, A. K., Stocks, B., Gonzalez-Franquesa, A., Larsen, J. K., Quesada, J. P., Thomassen, M., Weinert, B. T., Bangsbo, J., & Deshmukh, A. S. (2022). High-intensity interval training remodels the proteome and acetylome of human skeletal muscle. eLife, 11, [69802]. https://doi.org/10.7554/eLife.69802

Vancouver

Hostrup M, Lemminger AK, Stocks B, Gonzalez-Franquesa A, Larsen JK, Quesada JP et al. High-intensity interval training remodels the proteome and acetylome of human skeletal muscle. eLife. 2022;11. 69802. https://doi.org/10.7554/eLife.69802

Author

Hostrup, Morten ; Lemminger, Anders Krogh ; Stocks, Ben ; Gonzalez-Franquesa, Alba ; Larsen, Jeppe Kjærgaard ; Quesada, Julia Prats ; Thomassen, Martin ; Weinert, Brian Tate ; Bangsbo, Jens ; Deshmukh, Atul Shahaji. / High-intensity interval training remodels the proteome and acetylome of human skeletal muscle. In: eLife. 2022 ; Vol. 11.

Bibtex

@article{bbb1e969489b4ba3b8dc7d84eb6f93e7,
title = "High-intensity interval training remodels the proteome and acetylome of human skeletal muscle",
abstract = "Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.",
author = "Morten Hostrup and Lemminger, {Anders Krogh} and Ben Stocks and Alba Gonzalez-Franquesa and Larsen, {Jeppe Kj{\ae}rgaard} and Quesada, {Julia Prats} and Martin Thomassen and Weinert, {Brian Tate} and Jens Bangsbo and Deshmukh, {Atul Shahaji}",
note = "{\textcopyright} 2022, Hostrup et al.",
year = "2022",
doi = "10.7554/eLife.69802",
language = "English",
volume = "11",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

AU - Hostrup, Morten

AU - Lemminger, Anders Krogh

AU - Stocks, Ben

AU - Gonzalez-Franquesa, Alba

AU - Larsen, Jeppe Kjærgaard

AU - Quesada, Julia Prats

AU - Thomassen, Martin

AU - Weinert, Brian Tate

AU - Bangsbo, Jens

AU - Deshmukh, Atul Shahaji

N1 - © 2022, Hostrup et al.

PY - 2022

Y1 - 2022

N2 - Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.

AB - Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.

U2 - 10.7554/eLife.69802

DO - 10.7554/eLife.69802

M3 - Journal article

C2 - 35638262

VL - 11

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 69802

ER -

ID: 308364978