Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. / Gonzalez-Franquesa, Alba; Gama-Perez, Pau; Kulis, Marta; Szczepanowska, Karolina; Dahdah, Norma; Moreno-Gomez, Sonia; Latorre-Pellicer, Ana; Fernández-Ruiz, Rebeca; Aguilar-Mogas, Antoni; Hoffman, Anne; Monelli, Erika; Samino, Sara; Miró-Blanch, Joan; Oemer, Gregor; Duran, Xavier; Sanchez-Rebordelo, Estrella; Schneeberger, Marc; Obach, Merce; Montane, Joel; Castellano, Giancarlo; Chapaprieta, Vicente; Sun, Wenfei; Navarro, Lourdes; Prieto, Ignacio; Castaño, Carlos; Novials, Anna; Gomis, Ramon; Monsalve, Maria; Claret, Marc; Graupera, Mariona; Soria, Guadalupe; Wolfrum, Christian; Vendrell, Joan; Fernández-Veledo, Sonia; Enríquez, Jose Antonio; Carracedo, Angel; Perales, José Carlos; Nogueiras, Rubén; Herrero, Laura; Trifunovic, Aleksandra; Keller, Markus A.; Yanes, Oscar; Sales-Pardo, Marta; Guimerà, Roger; Blüher, Matthias; Martín-Subero, José Ignacio; Garcia-Roves, Pablo M.

In: Redox Biology, Vol. 54, 102353, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gonzalez-Franquesa, A, Gama-Perez, P, Kulis, M, Szczepanowska, K, Dahdah, N, Moreno-Gomez, S, Latorre-Pellicer, A, Fernández-Ruiz, R, Aguilar-Mogas, A, Hoffman, A, Monelli, E, Samino, S, Miró-Blanch, J, Oemer, G, Duran, X, Sanchez-Rebordelo, E, Schneeberger, M, Obach, M, Montane, J, Castellano, G, Chapaprieta, V, Sun, W, Navarro, L, Prieto, I, Castaño, C, Novials, A, Gomis, R, Monsalve, M, Claret, M, Graupera, M, Soria, G, Wolfrum, C, Vendrell, J, Fernández-Veledo, S, Enríquez, JA, Carracedo, A, Perales, JC, Nogueiras, R, Herrero, L, Trifunovic, A, Keller, MA, Yanes, O, Sales-Pardo, M, Guimerà, R, Blüher, M, Martín-Subero, JI & Garcia-Roves, PM 2022, 'Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue', Redox Biology, vol. 54, 102353. https://doi.org/10.1016/j.redox.2022.102353

APA

Gonzalez-Franquesa, A., Gama-Perez, P., Kulis, M., Szczepanowska, K., Dahdah, N., Moreno-Gomez, S., Latorre-Pellicer, A., Fernández-Ruiz, R., Aguilar-Mogas, A., Hoffman, A., Monelli, E., Samino, S., Miró-Blanch, J., Oemer, G., Duran, X., Sanchez-Rebordelo, E., Schneeberger, M., Obach, M., Montane, J., ... Garcia-Roves, P. M. (2022). Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biology, 54, [102353]. https://doi.org/10.1016/j.redox.2022.102353

Vancouver

Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S et al. Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biology. 2022;54. 102353. https://doi.org/10.1016/j.redox.2022.102353

Author

Gonzalez-Franquesa, Alba ; Gama-Perez, Pau ; Kulis, Marta ; Szczepanowska, Karolina ; Dahdah, Norma ; Moreno-Gomez, Sonia ; Latorre-Pellicer, Ana ; Fernández-Ruiz, Rebeca ; Aguilar-Mogas, Antoni ; Hoffman, Anne ; Monelli, Erika ; Samino, Sara ; Miró-Blanch, Joan ; Oemer, Gregor ; Duran, Xavier ; Sanchez-Rebordelo, Estrella ; Schneeberger, Marc ; Obach, Merce ; Montane, Joel ; Castellano, Giancarlo ; Chapaprieta, Vicente ; Sun, Wenfei ; Navarro, Lourdes ; Prieto, Ignacio ; Castaño, Carlos ; Novials, Anna ; Gomis, Ramon ; Monsalve, Maria ; Claret, Marc ; Graupera, Mariona ; Soria, Guadalupe ; Wolfrum, Christian ; Vendrell, Joan ; Fernández-Veledo, Sonia ; Enríquez, Jose Antonio ; Carracedo, Angel ; Perales, José Carlos ; Nogueiras, Rubén ; Herrero, Laura ; Trifunovic, Aleksandra ; Keller, Markus A. ; Yanes, Oscar ; Sales-Pardo, Marta ; Guimerà, Roger ; Blüher, Matthias ; Martín-Subero, José Ignacio ; Garcia-Roves, Pablo M. / Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. In: Redox Biology. 2022 ; Vol. 54.

Bibtex

@article{a41053f6b2ce4d5fba3ad4ec89ceeb72,
title = "Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue",
abstract = "Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.",
keywords = "Caloric restriction, Exercise, Human obesity, Metabolic fingerprint, Metabolic plasticity, Mitochondrial dysfunction, Multi-organ approach, Obesity, Two-steps bariatric surgery, Visceral adipose tissue",
author = "Alba Gonzalez-Franquesa and Pau Gama-Perez and Marta Kulis and Karolina Szczepanowska and Norma Dahdah and Sonia Moreno-Gomez and Ana Latorre-Pellicer and Rebeca Fern{\'a}ndez-Ruiz and Antoni Aguilar-Mogas and Anne Hoffman and Erika Monelli and Sara Samino and Joan Mir{\'o}-Blanch and Gregor Oemer and Xavier Duran and Estrella Sanchez-Rebordelo and Marc Schneeberger and Merce Obach and Joel Montane and Giancarlo Castellano and Vicente Chapaprieta and Wenfei Sun and Lourdes Navarro and Ignacio Prieto and Carlos Casta{\~n}o and Anna Novials and Ramon Gomis and Maria Monsalve and Marc Claret and Mariona Graupera and Guadalupe Soria and Christian Wolfrum and Joan Vendrell and Sonia Fern{\'a}ndez-Veledo and Enr{\'i}quez, {Jose Antonio} and Angel Carracedo and Perales, {Jos{\'e} Carlos} and Rub{\'e}n Nogueiras and Laura Herrero and Aleksandra Trifunovic and Keller, {Markus A.} and Oscar Yanes and Marta Sales-Pardo and Roger Guimer{\`a} and Matthias Bl{\"u}her and Mart{\'i}n-Subero, {Jos{\'e} Ignacio} and Garcia-Roves, {Pablo M.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.redox.2022.102353",
language = "English",
volume = "54",
journal = "Redox Biology",
issn = "2213-2317",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

AU - Gonzalez-Franquesa, Alba

AU - Gama-Perez, Pau

AU - Kulis, Marta

AU - Szczepanowska, Karolina

AU - Dahdah, Norma

AU - Moreno-Gomez, Sonia

AU - Latorre-Pellicer, Ana

AU - Fernández-Ruiz, Rebeca

AU - Aguilar-Mogas, Antoni

AU - Hoffman, Anne

AU - Monelli, Erika

AU - Samino, Sara

AU - Miró-Blanch, Joan

AU - Oemer, Gregor

AU - Duran, Xavier

AU - Sanchez-Rebordelo, Estrella

AU - Schneeberger, Marc

AU - Obach, Merce

AU - Montane, Joel

AU - Castellano, Giancarlo

AU - Chapaprieta, Vicente

AU - Sun, Wenfei

AU - Navarro, Lourdes

AU - Prieto, Ignacio

AU - Castaño, Carlos

AU - Novials, Anna

AU - Gomis, Ramon

AU - Monsalve, Maria

AU - Claret, Marc

AU - Graupera, Mariona

AU - Soria, Guadalupe

AU - Wolfrum, Christian

AU - Vendrell, Joan

AU - Fernández-Veledo, Sonia

AU - Enríquez, Jose Antonio

AU - Carracedo, Angel

AU - Perales, José Carlos

AU - Nogueiras, Rubén

AU - Herrero, Laura

AU - Trifunovic, Aleksandra

AU - Keller, Markus A.

AU - Yanes, Oscar

AU - Sales-Pardo, Marta

AU - Guimerà, Roger

AU - Blüher, Matthias

AU - Martín-Subero, José Ignacio

AU - Garcia-Roves, Pablo M.

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.

AB - Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.

KW - Caloric restriction

KW - Exercise

KW - Human obesity

KW - Metabolic fingerprint

KW - Metabolic plasticity

KW - Mitochondrial dysfunction

KW - Multi-organ approach

KW - Obesity

KW - Two-steps bariatric surgery

KW - Visceral adipose tissue

U2 - 10.1016/j.redox.2022.102353

DO - 10.1016/j.redox.2022.102353

M3 - Journal article

C2 - 35777200

AN - SCOPUS:85133597848

VL - 54

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

M1 - 102353

ER -

ID: 314440782