Housing temperature influences exercise training adaptations in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Housing temperature influences exercise training adaptations in mice. / Raun, Steffen Henning; Henriquez-Olguín, Carlos; Karavaeva, Iuliia; Ali, Mona; Møller, Lisbeth Liliendal Valbjørn; Kot, Witold; Castro-Mejía, Josué Leonardo; Nielsen, Dennis Sandris; Gerhart-Hines, Zachary; Richter, Erik A.; Sylow, Lykke.

In: Nature Communications, Vol. 11, 1560, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Raun, SH, Henriquez-Olguín, C, Karavaeva, I, Ali, M, Møller, LLV, Kot, W, Castro-Mejía, JL, Nielsen, DS, Gerhart-Hines, Z, Richter, EA & Sylow, L 2020, 'Housing temperature influences exercise training adaptations in mice', Nature Communications, vol. 11, 1560. https://doi.org/10.1038/s41467-020-15311-y

APA

Raun, S. H., Henriquez-Olguín, C., Karavaeva, I., Ali, M., Møller, L. L. V., Kot, W., Castro-Mejía, J. L., Nielsen, D. S., Gerhart-Hines, Z., Richter, E. A., & Sylow, L. (2020). Housing temperature influences exercise training adaptations in mice. Nature Communications, 11, [1560]. https://doi.org/10.1038/s41467-020-15311-y

Vancouver

Raun SH, Henriquez-Olguín C, Karavaeva I, Ali M, Møller LLV, Kot W et al. Housing temperature influences exercise training adaptations in mice. Nature Communications. 2020;11. 1560. https://doi.org/10.1038/s41467-020-15311-y

Author

Raun, Steffen Henning ; Henriquez-Olguín, Carlos ; Karavaeva, Iuliia ; Ali, Mona ; Møller, Lisbeth Liliendal Valbjørn ; Kot, Witold ; Castro-Mejía, Josué Leonardo ; Nielsen, Dennis Sandris ; Gerhart-Hines, Zachary ; Richter, Erik A. ; Sylow, Lykke. / Housing temperature influences exercise training adaptations in mice. In: Nature Communications. 2020 ; Vol. 11.

Bibtex

@article{bace0040ded146c5aff7304b39b88b7b,
title = "Housing temperature influences exercise training adaptations in mice",
abstract = "Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.",
author = "Raun, {Steffen Henning} and Carlos Henriquez-Olgu{\'i}n and Iuliia Karavaeva and Mona Ali and M{\o}ller, {Lisbeth Liliendal Valbj{\o}rn} and Witold Kot and Castro-Mej{\'i}a, {Josu{\'e} Leonardo} and Nielsen, {Dennis Sandris} and Zachary Gerhart-Hines and Richter, {Erik A.} and Lykke Sylow",
note = "CURIS 2020 NEXS 104",
year = "2020",
doi = "10.1038/s41467-020-15311-y",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Housing temperature influences exercise training adaptations in mice

AU - Raun, Steffen Henning

AU - Henriquez-Olguín, Carlos

AU - Karavaeva, Iuliia

AU - Ali, Mona

AU - Møller, Lisbeth Liliendal Valbjørn

AU - Kot, Witold

AU - Castro-Mejía, Josué Leonardo

AU - Nielsen, Dennis Sandris

AU - Gerhart-Hines, Zachary

AU - Richter, Erik A.

AU - Sylow, Lykke

N1 - CURIS 2020 NEXS 104

PY - 2020

Y1 - 2020

N2 - Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.

AB - Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.

U2 - 10.1038/s41467-020-15311-y

DO - 10.1038/s41467-020-15311-y

M3 - Journal article

C2 - 32214091

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1560

ER -

ID: 239563350