Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

Research output: Contribution to journal › Journal article › peer-review

Standard

Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. / Pedersen, Julie S; Rygg, Marte O; Chrøis, Karoline; Sustarsic, Elahu G; Gerhart-Hines, Zach; Wever Albrechtsen, Nicolai J; Serizawa, Reza R; Kristiansen, Viggo B; Basse, Astrid L; Boilesen, Astrid E B; Olsen, Beth H; Hansen, Torben; Gluud, Lise Lotte; Madsbad, Sten; Larsen, Steen; Bendtsen, Flemming; Dela, Flemming.

In: Nature Communications, Vol. 13, 2931, 2022.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Pedersen, JS, Rygg, MO, Chrøis, K, Sustarsic, EG, Gerhart-Hines, Z, Wever Albrechtsen, NJ, Serizawa, RR, Kristiansen, VB, Basse, AL, Boilesen, AEB, Olsen, BH, Hansen, T, Gluud, LL, Madsbad, S, Larsen, S, Bendtsen, F & Dela, F 2022, 'Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration', Nature Communications, vol. 13, 2931. https://doi.org/10.1038/s41467-022-30629-5

APA

Pedersen, J. S., Rygg, M. O., Chrøis, K., Sustarsic, E. G., Gerhart-Hines, Z., Wever Albrechtsen, N. J., Serizawa, R. R., Kristiansen, V. B., Basse, A. L., Boilesen, A. E. B., Olsen, B. H., Hansen, T., Gluud, L. L., Madsbad, S., Larsen, S., Bendtsen, F., & Dela, F. (2022). Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nature Communications, 13, [2931]. https://doi.org/10.1038/s41467-022-30629-5

Vancouver

Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ et al. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. Nature Communications. 2022;13. 2931. https://doi.org/10.1038/s41467-022-30629-5

Author

Pedersen, Julie S ; Rygg, Marte O ; Chrøis, Karoline ; Sustarsic, Elahu G ; Gerhart-Hines, Zach ; Wever Albrechtsen, Nicolai J ; Serizawa, Reza R ; Kristiansen, Viggo B ; Basse, Astrid L ; Boilesen, Astrid E B ; Olsen, Beth H ; Hansen, Torben ; Gluud, Lise Lotte ; Madsbad, Sten ; Larsen, Steen ; Bendtsen, Flemming ; Dela, Flemming. / Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. In: Nature Communications. 2022 ; Vol. 13.

Bibtex

@article{52b83287f81645a8bb10ff33573adb64,
title = "Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration",
abstract = "Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.",
keywords = "Adipose Tissue/pathology, Bariatric Surgery, Humans, Liver/pathology, Non-alcoholic Fatty Liver Disease/pathology, Obesity/complications, Obesity, Morbid/complications, Organelle Biogenesis, Respiration",
author = "Pedersen, {Julie S} and Rygg, {Marte O} and Karoline Chr{\o}is and Sustarsic, {Elahu G} and Zach Gerhart-Hines and {Wever Albrechtsen}, {Nicolai J} and Serizawa, {Reza R} and Kristiansen, {Viggo B} and Basse, {Astrid L} and Boilesen, {Astrid E B} and Olsen, {Beth H} and Torben Hansen and Gluud, {Lise Lotte} and Sten Madsbad and Steen Larsen and Flemming Bendtsen and Flemming Dela",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-30629-5",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

AU - Pedersen, Julie S

AU - Rygg, Marte O

AU - Chrøis, Karoline

AU - Sustarsic, Elahu G

AU - Gerhart-Hines, Zach

AU - Wever Albrechtsen, Nicolai J

AU - Serizawa, Reza R

AU - Kristiansen, Viggo B

AU - Basse, Astrid L

AU - Boilesen, Astrid E B

AU - Olsen, Beth H

AU - Hansen, Torben

AU - Gluud, Lise Lotte

AU - Madsbad, Sten

AU - Larsen, Steen

AU - Bendtsen, Flemming

AU - Dela, Flemming

N1 - © 2022. The Author(s).

PY - 2022

Y1 - 2022

N2 - Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.

AB - Impaired mitochondrial oxidative phosphorylation (OXPHOS) in liver tissue has been hypothesised to contribute to the development of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). It is unknown whether OXPHOS capacities in human visceral (VAT) and subcutaneous adipose tissue (SAT) associate with NAFLD severity and how hepatic OXPHOS responds to improvement in NAFLD. In biopsies sampled from 62 patients with obesity undergoing bariatric surgery and nine control subjects without obesity we demonstrate that OXPHOS is reduced in VAT and SAT while increased in the liver in patients with obesity when compared with control subjects without obesity, but this was independent of NAFLD severity. In repeat liver biopsy sampling in 21 patients with obesity 12 months after bariatric surgery we found increased hepatic OXPHOS capacity and mitochondrial DNA/nuclear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD severity, however, bariatric surgery increases hepatic OXPHOS and mitochondrial biogenesis.

KW - Adipose Tissue/pathology

KW - Bariatric Surgery

KW - Humans

KW - Liver/pathology

KW - Non-alcoholic Fatty Liver Disease/pathology

KW - Obesity/complications

KW - Obesity, Morbid/complications

KW - Organelle Biogenesis

KW - Respiration

U2 - 10.1038/s41467-022-30629-5

DO - 10.1038/s41467-022-30629-5

M3 - Journal article

C2 - 35614135

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2931

ER -

ID: 310838124