Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases

Research output: Contribution to journalReviewResearchpeer-review


  • Fulltext

    Final published version, 618 KB, PDF document

Background: Thermogenic brown and beige adipocytes are recognized for their unique capacity to consume extraordinary levels of metabolites and lipids from the blood to fuel heat-producing catabolic processes [1–7]. In humans, the functions of thermogenic adipocytes are associated with cardiometabolic protection and improved glycemic control [8–13]. Consequently, engaging these macronutrient-consuming and energy-dissipating activities has gained attention as a promising therapeutic strategy for counteracting metabolic diseases, such as obesity and diabetes. Scope of review: In this review, we highlight new advances in our understanding of the physiological role of G protein-coupled receptors (GPCRs) in controlling thermogenic adipocyte biology. We further extend our discussion to the opportunities and challenges posed by pharmacologically targeting different elements of GPCR signaling in these highly specialized fat cells. Major conclusions: GPCRs represent appealing candidates through which to harness adipose thermogenesis. Yet safely and effectively targeting these druggable receptors on brown and beige adipocytes has thus far proven challenging. Therefore, continued interrogation across the GPCR landscape is necessary for future leaps within the field of thermogenic fat biology to unlock the therapeutic potential of adipocyte catabolism.

Original languageEnglish
Article number101474
JournalMolecular Metabolism
Number of pages8
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

    Research areas

  • Brown adipose tissue, Cell signaling, Diabetes, Energy expenditure, G protein-coupled receptor, Obesity

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 305686546