Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. / Segref, Alexandra; Vakkayil, Kavya L.; Padvitski, Tsimafei; Li, Qiaochu; Kroef, Virginia; Lormann, Jakob; Körner, Lioba; Finger, Fabian; Hoppe, Thorsten.

In: Nature Communications, Vol. 13, No. 1, 5874, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Segref, A, Vakkayil, KL, Padvitski, T, Li, Q, Kroef, V, Lormann, J, Körner, L, Finger, F & Hoppe, T 2022, 'Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling', Nature Communications, vol. 13, no. 1, 5874. https://doi.org/10.1038/s41467-022-33467-7

APA

Segref, A., Vakkayil, K. L., Padvitski, T., Li, Q., Kroef, V., Lormann, J., Körner, L., Finger, F., & Hoppe, T. (2022). Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Nature Communications, 13(1), [5874]. https://doi.org/10.1038/s41467-022-33467-7

Vancouver

Segref A, Vakkayil KL, Padvitski T, Li Q, Kroef V, Lormann J et al. Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Nature Communications. 2022;13(1). 5874. https://doi.org/10.1038/s41467-022-33467-7

Author

Segref, Alexandra ; Vakkayil, Kavya L. ; Padvitski, Tsimafei ; Li, Qiaochu ; Kroef, Virginia ; Lormann, Jakob ; Körner, Lioba ; Finger, Fabian ; Hoppe, Thorsten. / Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. In: Nature Communications. 2022 ; Vol. 13, No. 1.

Bibtex

@article{80ad1fa4b16f4bac9f09a2ebc4f52b5e,
title = "Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling",
abstract = "Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms.",
author = "Alexandra Segref and Vakkayil, {Kavya L.} and Tsimafei Padvitski and Qiaochu Li and Virginia Kroef and Jakob Lormann and Lioba K{\"o}rner and Fabian Finger and Thorsten Hoppe",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-33467-7",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling

AU - Segref, Alexandra

AU - Vakkayil, Kavya L.

AU - Padvitski, Tsimafei

AU - Li, Qiaochu

AU - Kroef, Virginia

AU - Lormann, Jakob

AU - Körner, Lioba

AU - Finger, Fabian

AU - Hoppe, Thorsten

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms.

AB - Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms.

U2 - 10.1038/s41467-022-33467-7

DO - 10.1038/s41467-022-33467-7

M3 - Journal article

C2 - 36198694

AN - SCOPUS:85139349933

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5874

ER -

ID: 322788984