Acute metabolic effects of melatonin - A randomized crossover study in healthy young men

Research output: Contribution to journalJournal articlepeer-review

Standard

Acute metabolic effects of melatonin - A randomized crossover study in healthy young men. / Kampmann, Ulla; Lauritzen, Esben S.; Grarup, Niels; Jessen, Niels; Hansen, Torben; Møller, Niels; Stoy, Julie.

In: Journal of Pineal Research, Vol. 70, No. 2, 12706, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kampmann, U, Lauritzen, ES, Grarup, N, Jessen, N, Hansen, T, Møller, N & Stoy, J 2021, 'Acute metabolic effects of melatonin - A randomized crossover study in healthy young men', Journal of Pineal Research, vol. 70, no. 2, 12706. https://doi.org/10.1111/jpi.12706

APA

Kampmann, U., Lauritzen, E. S., Grarup, N., Jessen, N., Hansen, T., Møller, N., & Stoy, J. (2021). Acute metabolic effects of melatonin - A randomized crossover study in healthy young men. Journal of Pineal Research, 70(2), [12706]. https://doi.org/10.1111/jpi.12706

Vancouver

Kampmann U, Lauritzen ES, Grarup N, Jessen N, Hansen T, Møller N et al. Acute metabolic effects of melatonin - A randomized crossover study in healthy young men. Journal of Pineal Research. 2021;70(2). 12706. https://doi.org/10.1111/jpi.12706

Author

Kampmann, Ulla ; Lauritzen, Esben S. ; Grarup, Niels ; Jessen, Niels ; Hansen, Torben ; Møller, Niels ; Stoy, Julie. / Acute metabolic effects of melatonin - A randomized crossover study in healthy young men. In: Journal of Pineal Research. 2021 ; Vol. 70, No. 2.

Bibtex

@article{913dbf8537e146e395a97c0a5894df19,
title = "Acute metabolic effects of melatonin - A randomized crossover study in healthy young men",
abstract = "Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A common G-allele in the MTNR1B locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two nonconsecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic-euglycaemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index was significantly reduced on the melatonin day (P = .028) in the whole group and in homozygous carriers of the rs10830963 C-allele (P = .041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.",
keywords = "blood pressure, genotype, insulin secretion, insulin sensitivity, lipid oxidation, melatonin, melatonin receptor, FASTING PLASMA-GLUCOSE, INSULIN SENSITIVITY, DIABETES-MELLITUS, RECEPTOR 1B, MTNR1B, ASSOCIATION, TOLERANCE, VARIANT, RISK, EXPRESSION",
author = "Ulla Kampmann and Lauritzen, {Esben S.} and Niels Grarup and Niels Jessen and Torben Hansen and Niels M{\o}ller and Julie Stoy",
year = "2021",
doi = "10.1111/jpi.12706",
language = "English",
volume = "70",
journal = "Journal of Pineal Research (Print)",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Acute metabolic effects of melatonin - A randomized crossover study in healthy young men

AU - Kampmann, Ulla

AU - Lauritzen, Esben S.

AU - Grarup, Niels

AU - Jessen, Niels

AU - Hansen, Torben

AU - Møller, Niels

AU - Stoy, Julie

PY - 2021

Y1 - 2021

N2 - Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A common G-allele in the MTNR1B locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two nonconsecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic-euglycaemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index was significantly reduced on the melatonin day (P = .028) in the whole group and in homozygous carriers of the rs10830963 C-allele (P = .041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.

AB - Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A common G-allele in the MTNR1B locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two nonconsecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic-euglycaemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index was significantly reduced on the melatonin day (P = .028) in the whole group and in homozygous carriers of the rs10830963 C-allele (P = .041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.

KW - blood pressure

KW - genotype

KW - insulin secretion

KW - insulin sensitivity

KW - lipid oxidation

KW - melatonin

KW - melatonin receptor

KW - FASTING PLASMA-GLUCOSE

KW - INSULIN SENSITIVITY

KW - DIABETES-MELLITUS

KW - RECEPTOR 1B

KW - MTNR1B

KW - ASSOCIATION

KW - TOLERANCE

KW - VARIANT

KW - RISK

KW - EXPRESSION

U2 - 10.1111/jpi.12706

DO - 10.1111/jpi.12706

M3 - Journal article

C2 - 33220095

VL - 70

JO - Journal of Pineal Research (Print)

JF - Journal of Pineal Research (Print)

SN - 0742-3098

IS - 2

M1 - 12706

ER -

ID: 253446808