Acute metabolic effects of melatonin - A randomized crossover study in healthy young men
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Acute metabolic effects of melatonin - A randomized crossover study in healthy young men. / Kampmann, Ulla; Lauritzen, Esben S.; Grarup, Niels; Jessen, Niels; Hansen, Torben; Møller, Niels; Stoy, Julie.
In: Journal of Pineal Research, Vol. 70, No. 2, 12706, 2021.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Acute metabolic effects of melatonin - A randomized crossover study in healthy young men
AU - Kampmann, Ulla
AU - Lauritzen, Esben S.
AU - Grarup, Niels
AU - Jessen, Niels
AU - Hansen, Torben
AU - Møller, Niels
AU - Stoy, Julie
PY - 2021
Y1 - 2021
N2 - Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A common G-allele in the MTNR1B locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two nonconsecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic-euglycaemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index was significantly reduced on the melatonin day (P = .028) in the whole group and in homozygous carriers of the rs10830963 C-allele (P = .041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.
AB - Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A common G-allele in the MTNR1B locus has been associated with an increased risk of type 2 diabetes (T2DM). We aimed to examine acute effects of high doses of melatonin on glucose metabolism with attention to MTNR1B genotype. Twenty men were examined in a double-blinded, randomized crossover study on two nonconsecutive days with four doses of 10 mg oral melatonin or placebo. Insulin sensitivity and insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic-euglycaemic clamp (HEC). Blood samples were drawn to determine the metabolic profile and MTNR1B rs10830963 genotype. Indirect calorimetry and blood pressure measurements were also performed. Insulin sensitivity index was significantly reduced on the melatonin day (P = .028) in the whole group and in homozygous carriers of the rs10830963 C-allele (P = .041). Glucose during the IVGTT was unaffected, but there was a tendency towards lower insulin and C-peptide levels in the first minutes after glucose administration in G-allele carriers. Systolic blood pressure decreased and lipid oxidation increased significantly on the melatonin day in rs10830963 G-allele carriers. Overall, our study reports that acute administration of melatonin in supra-physiological doses may have a negative impact on insulin sensitivity.
KW - blood pressure
KW - genotype
KW - insulin secretion
KW - insulin sensitivity
KW - lipid oxidation
KW - melatonin
KW - melatonin receptor
KW - FASTING PLASMA-GLUCOSE
KW - INSULIN SENSITIVITY
KW - DIABETES-MELLITUS
KW - RECEPTOR 1B
KW - MTNR1B
KW - ASSOCIATION
KW - TOLERANCE
KW - VARIANT
KW - RISK
KW - EXPRESSION
U2 - 10.1111/jpi.12706
DO - 10.1111/jpi.12706
M3 - Journal article
C2 - 33220095
VL - 70
JO - Journal of Pineal Research (Print)
JF - Journal of Pineal Research (Print)
SN - 0742-3098
IS - 2
M1 - 12706
ER -
ID: 253446808