TY - JOUR

T1 - Association of alcohol consumption with allergic disease and asthma

T2 - a multi-centre Mendelian randomization analysis

AU - Skaaby, Tea

AU - Kilpeläinen, Tuomas O.

AU - Taylor, Amy E

AU - Mahendran, Yuvaraj

AU - Wong, Andrew

AU - Ahluwalia, Tarunveer S

AU - Paternoster, Lavinia

AU - Trompet, Stella

AU - Stott, David J

AU - Flexeder, Claudia

AU - Zhou, Ang

AU - Brusselle, Guy

AU - Sajjad, Ayesha

AU - Lahousse, Lies

AU - Tiemeier, Henning

AU - Have, Christian Theil

AU - Thuesen, Betina H

AU - Kårhus, Line Lund

AU - Møllehave, Line Tang

AU - Leth-Møller, Katja Biering

AU - Shabanzadeh, Daniel Mønsted

AU - Gonzalez-Quintela, Arturo

AU - Power, Chris

AU - Hyppönen, Elina

AU - Kuh, Diana

AU - Hardy, Rebecca

AU - Meitinger, Thomas

AU - Jukema, J Wouter

AU - Völker, Uwe

AU - Nauck, Matthias

AU - Völzke, Henry

AU - Friedrich, Nele

AU - Bonten, Tobias N

AU - Noordam, Raymond

AU - Mook-Kanamori, Dennis O

AU - Tolstrup, Janne S.

AU - Taube, Christian

AU - Peters, Annette

AU - Grallert, Harald

AU - Strauch, Konstantin

AU - Schulz, Holger

AU - Grarup, Niels

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Burgess, Stephen

AU - Munafò, Marcus R

AU - Linneberg, Allan

N1 - © 2018 Society for the Study of Addiction.

PY - 2019

Y1 - 2019

N2 - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

AB - AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions.SETTING: Europe.PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015.MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples.FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE.CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.

KW - Alcohol

KW - allergic disease

KW - allergic sensitization

KW - asthma

KW - hay fever

KW - mendelian randomization

U2 - 10.1111/add.14438

DO - 10.1111/add.14438

M3 - Journal article

C2 - 30209858

VL - 114

SP - 216

EP - 225

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 2

ER -