PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
Research output: Contribution to journal › Journal article › Research › peer-review
Recently, an amino acid variant (K121Q) in the glycoprotein PC-1 (Q allele) has been associated with faster progression of diabetic nephropathy, as estimated by calculated creatinine clearance. We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique.
| Original language | English |
|---|---|
| Journal | Nephrology, Dialysis, Transplantation |
| Volume | 17 |
| Issue number | 8 |
| Pages (from-to) | 1408-12 |
| Number of pages | 5 |
| ISSN | 0931-0509 |
| Publication status | Published - 2002 |
- Adult, Age of Onset, Amino Acid Substitution, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Disease Progression, Female, Follow-Up Studies, Genetic Variation, Genotype, Glomerular Filtration Rate, Heterozygote Detection, Humans, Male, Phosphoric Diester Hydrolases, Pyrophosphatases, Time Factors
Research areas
ID: 38457959