14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes. / Gjesing, Anette P.; Engelbrechtsen, Line; Cathrine B. Thuesen, Anne; Have, Christian T.; Hollensted, Mette; Grarup, Niels; Linneberg, Allan; Steen Nielsen, Jens; Christensen, Lotte B.; Thomsen, Reimar W.; Johansson, Kristoffer E.; Cagiada, Matteo; Gersing, Sarah; Hartmann-Petersen, Rasmus; Lindorff-Larsen, Kresten; Vaag, Allan; Sørensen, Henrik T.; Brandslund, Ivan; Beck-Nielsen, Henning; Pedersen, Oluf; Rungby, Jørgen; Hansen, Torben.

In: Diabetes Research and Clinical Practice, Vol. 194, 110159, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gjesing, AP, Engelbrechtsen, L, Cathrine B. Thuesen, A, Have, CT, Hollensted, M, Grarup, N, Linneberg, A, Steen Nielsen, J, Christensen, LB, Thomsen, RW, Johansson, KE, Cagiada, M, Gersing, S, Hartmann-Petersen, R, Lindorff-Larsen, K, Vaag, A, Sørensen, HT, Brandslund, I, Beck-Nielsen, H, Pedersen, O, Rungby, J & Hansen, T 2022, '14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes', Diabetes Research and Clinical Practice, vol. 194, 110159. https://doi.org/10.1016/j.diabres.2022.110159

APA

Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., ... Hansen, T. (2022). 14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes. Diabetes Research and Clinical Practice, 194, [110159]. https://doi.org/10.1016/j.diabres.2022.110159

Vancouver

Gjesing AP, Engelbrechtsen L, Cathrine B. Thuesen A, Have CT, Hollensted M, Grarup N et al. 14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes. Diabetes Research and Clinical Practice. 2022;194. 110159. https://doi.org/10.1016/j.diabres.2022.110159

Author

Gjesing, Anette P. ; Engelbrechtsen, Line ; Cathrine B. Thuesen, Anne ; Have, Christian T. ; Hollensted, Mette ; Grarup, Niels ; Linneberg, Allan ; Steen Nielsen, Jens ; Christensen, Lotte B. ; Thomsen, Reimar W. ; Johansson, Kristoffer E. ; Cagiada, Matteo ; Gersing, Sarah ; Hartmann-Petersen, Rasmus ; Lindorff-Larsen, Kresten ; Vaag, Allan ; Sørensen, Henrik T. ; Brandslund, Ivan ; Beck-Nielsen, Henning ; Pedersen, Oluf ; Rungby, Jørgen ; Hansen, Torben. / 14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes. In: Diabetes Research and Clinical Practice. 2022 ; Vol. 194.

Bibtex

@article{f58ec4b81b284dbaa36362a66a09597a,
title = "14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes",
abstract = "Aims: Rare variants in the glucokinase gene (GCK) cause Maturity-Onset Diabetes of the Young (MODY2/GCK-MODY). We investigated the prevalence of GCK variants, phenotypic characteristics, micro- and macrovascular disease at baseline and follow-up, and treatment among individuals with and without pathogenic GCK variants. Methods: This is a cross-sectional study in a population-based cohort of 5,433 individuals without diabetes (Inter99 cohort) and in 2,855 patients with a new clinical diagnosis of type 2 diabetes (DD2 cohort) with sequencing of GCK. Phenotypic characteristics, presence of micro- and macrovascular disease and treatment information were available for patients in the DD2 cohort at baseline and after an average follow-up of 7.4 years. Results: Twenty-two carriers of potentially deleterious GCK variants were found among patients with type 2 diabetes compared to three among 5,433 nondiabetic individuals [OR = 14.1 (95 % CI 4.2; 47.0), p = 8.9*10-6]. Patients with type 2 diabetes carrying GCK variants had significantly lower waist circumference, hip circumference and BMI, compared to non-carriers. Three GCK variant carriers with diabetes had microvascular complications during follow-up. Conclusions: Approximately 0.8% of Danish patients with newly diagnosed type 2 diabetes carry non-synonymous variants in GCK and resemble patients with GCK-MODY. Glucose-lowering treatment cessation should be considered in this subset of diabetes patients.",
keywords = "Complications, Glucokinase, Macrovascular, Microvascular, MODY, Monogenic diabetes",
author = "Gjesing, {Anette P.} and Line Engelbrechtsen and {Cathrine B. Thuesen}, Anne and Have, {Christian T.} and Mette Hollensted and Niels Grarup and Allan Linneberg and {Steen Nielsen}, Jens and Christensen, {Lotte B.} and Thomsen, {Reimar W.} and Johansson, {Kristoffer E.} and Matteo Cagiada and Sarah Gersing and Rasmus Hartmann-Petersen and Kresten Lindorff-Larsen and Allan Vaag and S{\o}rensen, {Henrik T.} and Ivan Brandslund and Henning Beck-Nielsen and Oluf Pedersen and J{\o}rgen Rungby and Torben Hansen",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.diabres.2022.110159",
language = "English",
volume = "194",
journal = "Diabetes Research and Clinical Practice. Supplement",
issn = "1572-1671",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - 14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes

AU - Gjesing, Anette P.

AU - Engelbrechtsen, Line

AU - Cathrine B. Thuesen, Anne

AU - Have, Christian T.

AU - Hollensted, Mette

AU - Grarup, Niels

AU - Linneberg, Allan

AU - Steen Nielsen, Jens

AU - Christensen, Lotte B.

AU - Thomsen, Reimar W.

AU - Johansson, Kristoffer E.

AU - Cagiada, Matteo

AU - Gersing, Sarah

AU - Hartmann-Petersen, Rasmus

AU - Lindorff-Larsen, Kresten

AU - Vaag, Allan

AU - Sørensen, Henrik T.

AU - Brandslund, Ivan

AU - Beck-Nielsen, Henning

AU - Pedersen, Oluf

AU - Rungby, Jørgen

AU - Hansen, Torben

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Aims: Rare variants in the glucokinase gene (GCK) cause Maturity-Onset Diabetes of the Young (MODY2/GCK-MODY). We investigated the prevalence of GCK variants, phenotypic characteristics, micro- and macrovascular disease at baseline and follow-up, and treatment among individuals with and without pathogenic GCK variants. Methods: This is a cross-sectional study in a population-based cohort of 5,433 individuals without diabetes (Inter99 cohort) and in 2,855 patients with a new clinical diagnosis of type 2 diabetes (DD2 cohort) with sequencing of GCK. Phenotypic characteristics, presence of micro- and macrovascular disease and treatment information were available for patients in the DD2 cohort at baseline and after an average follow-up of 7.4 years. Results: Twenty-two carriers of potentially deleterious GCK variants were found among patients with type 2 diabetes compared to three among 5,433 nondiabetic individuals [OR = 14.1 (95 % CI 4.2; 47.0), p = 8.9*10-6]. Patients with type 2 diabetes carrying GCK variants had significantly lower waist circumference, hip circumference and BMI, compared to non-carriers. Three GCK variant carriers with diabetes had microvascular complications during follow-up. Conclusions: Approximately 0.8% of Danish patients with newly diagnosed type 2 diabetes carry non-synonymous variants in GCK and resemble patients with GCK-MODY. Glucose-lowering treatment cessation should be considered in this subset of diabetes patients.

AB - Aims: Rare variants in the glucokinase gene (GCK) cause Maturity-Onset Diabetes of the Young (MODY2/GCK-MODY). We investigated the prevalence of GCK variants, phenotypic characteristics, micro- and macrovascular disease at baseline and follow-up, and treatment among individuals with and without pathogenic GCK variants. Methods: This is a cross-sectional study in a population-based cohort of 5,433 individuals without diabetes (Inter99 cohort) and in 2,855 patients with a new clinical diagnosis of type 2 diabetes (DD2 cohort) with sequencing of GCK. Phenotypic characteristics, presence of micro- and macrovascular disease and treatment information were available for patients in the DD2 cohort at baseline and after an average follow-up of 7.4 years. Results: Twenty-two carriers of potentially deleterious GCK variants were found among patients with type 2 diabetes compared to three among 5,433 nondiabetic individuals [OR = 14.1 (95 % CI 4.2; 47.0), p = 8.9*10-6]. Patients with type 2 diabetes carrying GCK variants had significantly lower waist circumference, hip circumference and BMI, compared to non-carriers. Three GCK variant carriers with diabetes had microvascular complications during follow-up. Conclusions: Approximately 0.8% of Danish patients with newly diagnosed type 2 diabetes carry non-synonymous variants in GCK and resemble patients with GCK-MODY. Glucose-lowering treatment cessation should be considered in this subset of diabetes patients.

KW - Complications

KW - Glucokinase

KW - Macrovascular

KW - Microvascular

KW - MODY

KW - Monogenic diabetes

U2 - 10.1016/j.diabres.2022.110159

DO - 10.1016/j.diabres.2022.110159

M3 - Journal article

C2 - 36400171

AN - SCOPUS:85143917075

VL - 194

JO - Diabetes Research and Clinical Practice. Supplement

JF - Diabetes Research and Clinical Practice. Supplement

SN - 1572-1671

M1 - 110159

ER -

ID: 333697133