Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

Research output: Contribution to journal › Journal article › Research › peer-review

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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. / Vogelezang, Suzanne; Bradfield, Jonathan P; Early Growth Genetics Consortium ; Ahluwalia, Tarun Veer Singh; Liu, Xueping; Schnurr, Theresia Maria; Frithioff-Bøjsøe, Christine; Bønnelykke, Klaus; Lind, Mads Vendelbo; Lauritzen, Lotte; Michaelsen, Kim F.; Lund, Morten Asp Vonsild; Melbye, Mads; Morgen, Camilla Schmidt; Pedersen, Oluf Borbye; Holm, Jens-Christian; Grarup, Niels; Hansen, Torben; Nohr, Ellen A; Bisgaard, Hans; Grant, Struan F A; Felix, Janine F; Jaddoe, Vincent W V.

In: BMC Medical Genomics, Vol. 15, 124, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vogelezang, S, Bradfield, JP, Early Growth Genetics Consortium, Ahluwalia, TVS, Liu, X, Schnurr, TM, Frithioff-Bøjsøe, C, Bønnelykke, K, Lind, MV, Lauritzen, L, Michaelsen, KF, Lund, MAV, Melbye, M, Morgen, CS, Pedersen, OB, Holm, J-C, Grarup, N, Hansen, T, Nohr, EA, Bisgaard, H, Grant, SFA, Felix, JF & Jaddoe, VWV 2022, 'Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes', BMC Medical Genomics, vol. 15, 124. https://doi.org/10.1186/s12920-022-01281-1

APA

Vogelezang, S., Bradfield, J. P., Early Growth Genetics Consortium, Ahluwalia, T. V. S., Liu, X., Schnurr, T. M., Frithioff-Bøjsøe, C., Bønnelykke, K., Lind, M. V., Lauritzen, L., Michaelsen, K. F., Lund, M. A. V., Melbye, M., Morgen, C. S., Pedersen, O. B., Holm, J-C., Grarup, N., Hansen, T., Nohr, E. A., ... Jaddoe, V. W. V. (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Medical Genomics, 15, [124]. https://doi.org/10.1186/s12920-022-01281-1

Vancouver

Vogelezang S, Bradfield JP, Early Growth Genetics Consortium, Ahluwalia TVS, Liu X, Schnurr TM et al. Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Medical Genomics. 2022;15. 124. https://doi.org/10.1186/s12920-022-01281-1

Author

Vogelezang, Suzanne ; Bradfield, Jonathan P ; Early Growth Genetics Consortium ; Ahluwalia, Tarun Veer Singh ; Liu, Xueping ; Schnurr, Theresia Maria ; Frithioff-Bøjsøe, Christine ; Bønnelykke, Klaus ; Lind, Mads Vendelbo ; Lauritzen, Lotte ; Michaelsen, Kim F. ; Lund, Morten Asp Vonsild ; Melbye, Mads ; Morgen, Camilla Schmidt ; Pedersen, Oluf Borbye ; Holm, Jens-Christian ; Grarup, Niels ; Hansen, Torben ; Nohr, Ellen A ; Bisgaard, Hans ; Grant, Struan F A ; Felix, Janine F ; Jaddoe, Vincent W V. / Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. In: BMC Medical Genomics. 2022 ; Vol. 15.

Bibtex

@article{2d6375662cd24c53a67fd708b943af5e,
title = "Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes",
abstract = "Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.",
keywords = "Head circumference, Infancy, Genetic correlations, Genome-Wide Association Study",
author = "Suzanne Vogelezang and Bradfield, {Jonathan P} and {Early Growth Genetics Consortium} and Ahluwalia, {Tarun Veer Singh} and Xueping Liu and Schnurr, {Theresia Maria} and Christine Frithioff-B{\o}js{\o}e and Klaus B{\o}nnelykke and Lind, {Mads Vendelbo} and Lotte Lauritzen and Michaelsen, {Kim F.} and Lund, {Morten Asp Vonsild} and Mads Melbye and Morgen, {Camilla Schmidt} and Pedersen, {Oluf Borbye} and Jens-Christian Holm and Niels Grarup and Torben Hansen and Nohr, {Ellen A} and Hans Bisgaard and Grant, {Struan F A} and Felix, {Janine F} and Jaddoe, {Vincent W V}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1186/s12920-022-01281-1",
language = "English",
volume = "15",
journal = "BMC Medical Genomics",
issn = "1755-8794",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

AU - Vogelezang, Suzanne

AU - Bradfield, Jonathan P

AU - Early Growth Genetics Consortium

AU - Ahluwalia, Tarun Veer Singh

AU - Liu, Xueping

AU - Schnurr, Theresia Maria

AU - Frithioff-Bøjsøe, Christine

AU - Bønnelykke, Klaus

AU - Lind, Mads Vendelbo

AU - Lauritzen, Lotte

AU - Michaelsen, Kim F.

AU - Lund, Morten Asp Vonsild

AU - Melbye, Mads

AU - Morgen, Camilla Schmidt

AU - Pedersen, Oluf Borbye

AU - Holm, Jens-Christian

AU - Grarup, Niels

AU - Hansen, Torben

AU - Nohr, Ellen A

AU - Bisgaard, Hans

AU - Grant, Struan F A

AU - Felix, Janine F

AU - Jaddoe, Vincent W V

N1 - © 2022. The Author(s).

PY - 2022

Y1 - 2022

N2 - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

AB - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

KW - Head circumference

KW - Infancy

KW - Genetic correlations

KW - Genome-Wide Association Study

U2 - 10.1186/s12920-022-01281-1

DO - 10.1186/s12920-022-01281-1

M3 - Journal article

C2 - 35659227

VL - 15

JO - BMC Medical Genomics

JF - BMC Medical Genomics

SN - 1755-8794

M1 - 124

ER -

ID: 309200587