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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. / Gretarsdottir, Solveig; Baas, Annette F; Thorleifsson, Gudmar; Holm, Hilma; den Heijer, Martin; de Vries, Jean-Paul P M; Kranendonk, Steef E; Zeebregts, Clark J A M; van Sterkenburg, Steven M; Geelkerken, Robert H; van Rij, Andre M; Williams, Michael J A; Boll, Albert P M; Kostic, Jelena P; Jonasdottir, Adalbjorg; Jonasdottir, Aslaug; Walters, G Bragi; Masson, Gisli; Sulem, Patrick; Saemundsdottir, Jona; Mouy, Magali; Magnusson, Kristinn P; Tromp, Gerard; Elmore, James R; Sakalihasan, Natzi; Limet, Raymond; Defraigne, Jean-Olivier; Ferrell, Robert E; Ronkainen, Antti; Ruigrok, Ynte M; Wijmenga, Cisca; Grobbee, Diederick E; Shah, Svati H; Granger, Christopher B; Quyyumi, Arshed A; Vaccarino, Viola; Patel, Riyaz S; Zafari, A Maziar; Levey, Allan I; Austin, Harland; Girelli, Domenico; Pignatti, Pier Franco; Olivieri, Oliviero; Martinelli, Nicola; Malerba, Giovanni; Trabetti, Elisabetta; Becker, Lewis C; Becker, Diane M; Reilly, Muredach P; Rader, Daniel J; Mueller, Thomas; Dieplinger, Benjamin; Haltmayer, Meinhard; Urbonavicius, Sigitas; Lindblad, Bengt; Gottsäter, Anders; Gaetani, Eleonora; Pola, Roberto; Wells, Philip; Rodger, Marc; Forgie, Melissa; Langlois, Nicole; Corral, Javier; Vasquez, Vicente; Fontcuberta, Jordi; España, Francisco; Grarup, Niels; Jørgensen, Torben; Witte, Daniel R; Hansen, Torben; Pedersen, Oluf; Aben, Katja K; de Graaf, Jacqueline; Holewijn, Suzanne; Folkersen, Lasse; Franco-Cereceda, Anders; Eriksson, Per; Collier, David A; Stefansson, Hreinn; Steinthorsdottir, Valgerdur; Rafnar, Thorunn; Valdimarsson, Einar M; Magnadottir, Hulda B; Sveinbjornsdottir, Sigurlaug; Olafsson, Isleifur; Magnusson, Magnus Karl; Palmason, Robert; Haraldsdottir, Vilhelmina; Andersen, Karl; Onundarson, Pall T; Thorgeirsson, Gudmundur; Kiemeney, Lambertus A; Powell, Janet T; Carey, David J; Kuivaniemi, Helena; Lindholt, Jes S.; Jones, Gregory T; Kong, Augustine; Blankensteijn, Jan D; Matthiasson, Stefan E; Thorsteinsdottir, Unnur; Stefansson, Kari.
In:
Nature Genetics, Vol. 42, No. 8, 01.08.2010, p. 692-7.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Gretarsdottir, S, Baas, AF, Thorleifsson, G, Holm, H, den Heijer, M, de Vries, J-PPM, Kranendonk, SE, Zeebregts, CJAM, van Sterkenburg, SM, Geelkerken, RH, van Rij, AM, Williams, MJA, Boll, APM, Kostic, JP, Jonasdottir, A, Jonasdottir, A, Walters, GB, Masson, G, Sulem, P, Saemundsdottir, J, Mouy, M, Magnusson, KP, Tromp, G, Elmore, JR, Sakalihasan, N, Limet, R, Defraigne, J-O, Ferrell, RE, Ronkainen, A, Ruigrok, YM, Wijmenga, C, Grobbee, DE, Shah, SH, Granger, CB, Quyyumi, AA, Vaccarino, V, Patel, RS, Zafari, AM, Levey, AI, Austin, H, Girelli, D, Pignatti, PF, Olivieri, O, Martinelli, N, Malerba, G, Trabetti, E, Becker, LC, Becker, DM, Reilly, MP, Rader, DJ, Mueller, T, Dieplinger, B, Haltmayer, M, Urbonavicius, S, Lindblad, B, Gottsäter, A, Gaetani, E, Pola, R, Wells, P, Rodger, M, Forgie, M, Langlois, N, Corral, J, Vasquez, V, Fontcuberta, J, España, F
, Grarup, N, Jørgensen, T, Witte, DR
, Hansen, T, Pedersen, O, Aben, KK, de Graaf, J, Holewijn, S, Folkersen, L, Franco-Cereceda, A, Eriksson, P, Collier, DA, Stefansson, H, Steinthorsdottir, V, Rafnar, T, Valdimarsson, EM, Magnadottir, HB, Sveinbjornsdottir, S, Olafsson, I, Magnusson, MK, Palmason, R, Haraldsdottir, V, Andersen, K, Onundarson, PT, Thorgeirsson, G, Kiemeney, LA, Powell, JT, Carey, DJ, Kuivaniemi, H, Lindholt, JS, Jones, GT, Kong, A, Blankensteijn, JD, Matthiasson, SE, Thorsteinsdottir, U & Stefansson, K 2010, '
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm',
Nature Genetics, vol. 42, no. 8, pp. 692-7.
https://doi.org/10.1038/ng.622APA
Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J-P. P. M., Kranendonk, S. E., Zeebregts, C. J. A. M., van Sterkenburg, S. M., Geelkerken, R. H., van Rij, A. M., Williams, M. J. A., Boll, A. P. M., Kostic, J. P., Jonasdottir, A., Jonasdottir, A., Walters, G. B., Masson, G., Sulem, P., ... Stefansson, K. (2010).
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Nature Genetics,
42(8), 692-7.
https://doi.org/10.1038/ng.622Vancouver
Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries J-PPM et al.
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Nature Genetics. 2010 Aug 1;42(8):692-7.
https://doi.org/10.1038/ng.622Author
Gretarsdottir, Solveig ; Baas, Annette F ; Thorleifsson, Gudmar ; Holm, Hilma ; den Heijer, Martin ; de Vries, Jean-Paul P M ; Kranendonk, Steef E ; Zeebregts, Clark J A M ; van Sterkenburg, Steven M ; Geelkerken, Robert H ; van Rij, Andre M ; Williams, Michael J A ; Boll, Albert P M ; Kostic, Jelena P ; Jonasdottir, Adalbjorg ; Jonasdottir, Aslaug ; Walters, G Bragi ; Masson, Gisli ; Sulem, Patrick ; Saemundsdottir, Jona ; Mouy, Magali ; Magnusson, Kristinn P ; Tromp, Gerard ; Elmore, James R ; Sakalihasan, Natzi ; Limet, Raymond ; Defraigne, Jean-Olivier ; Ferrell, Robert E ; Ronkainen, Antti ; Ruigrok, Ynte M ; Wijmenga, Cisca ; Grobbee, Diederick E ; Shah, Svati H ; Granger, Christopher B ; Quyyumi, Arshed A ; Vaccarino, Viola ; Patel, Riyaz S ; Zafari, A Maziar ; Levey, Allan I ; Austin, Harland ; Girelli, Domenico ; Pignatti, Pier Franco ; Olivieri, Oliviero ; Martinelli, Nicola ; Malerba, Giovanni ; Trabetti, Elisabetta ; Becker, Lewis C ; Becker, Diane M ; Reilly, Muredach P ; Rader, Daniel J ; Mueller, Thomas ; Dieplinger, Benjamin ; Haltmayer, Meinhard ; Urbonavicius, Sigitas ; Lindblad, Bengt ; Gottsäter, Anders ; Gaetani, Eleonora ; Pola, Roberto ; Wells, Philip ; Rodger, Marc ; Forgie, Melissa ; Langlois, Nicole ; Corral, Javier ; Vasquez, Vicente ; Fontcuberta, Jordi ; España, Francisco ; Grarup, Niels ; Jørgensen, Torben ; Witte, Daniel R ; Hansen, Torben ; Pedersen, Oluf ; Aben, Katja K ; de Graaf, Jacqueline ; Holewijn, Suzanne ; Folkersen, Lasse ; Franco-Cereceda, Anders ; Eriksson, Per ; Collier, David A ; Stefansson, Hreinn ; Steinthorsdottir, Valgerdur ; Rafnar, Thorunn ; Valdimarsson, Einar M ; Magnadottir, Hulda B ; Sveinbjornsdottir, Sigurlaug ; Olafsson, Isleifur ; Magnusson, Magnus Karl ; Palmason, Robert ; Haraldsdottir, Vilhelmina ; Andersen, Karl ; Onundarson, Pall T ; Thorgeirsson, Gudmundur ; Kiemeney, Lambertus A ; Powell, Janet T ; Carey, David J ; Kuivaniemi, Helena ; Lindholt, Jes S. ; Jones, Gregory T ; Kong, Augustine ; Blankensteijn, Jan D ; Matthiasson, Stefan E ; Thorsteinsdottir, Unnur ; Stefansson, Kari. / Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. In: Nature Genetics. 2010 ; Vol. 42, No. 8. pp. 692-7.
Bibtex
@article{9e57a563ae0b4085a821a931d2a783d0,
title = "Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm",
abstract = "We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.",
keywords = "Alleles, Aortic Aneurysm, Abdominal, Base Sequence, Disease Susceptibility, Genome-Wide Association Study, Humans, Hypertension, Iceland, Myocardial Infarction, Netherlands, Odds Ratio, Risk Factors, ras GTPase-Activating Proteins",
author = "Solveig Gretarsdottir and Baas, {Annette F} and Gudmar Thorleifsson and Hilma Holm and {den Heijer}, Martin and {de Vries}, {Jean-Paul P M} and Kranendonk, {Steef E} and Zeebregts, {Clark J A M} and {van Sterkenburg}, {Steven M} and Geelkerken, {Robert H} and {van Rij}, {Andre M} and Williams, {Michael J A} and Boll, {Albert P M} and Kostic, {Jelena P} and Adalbjorg Jonasdottir and Aslaug Jonasdottir and Walters, {G Bragi} and Gisli Masson and Patrick Sulem and Jona Saemundsdottir and Magali Mouy and Magnusson, {Kristinn P} and Gerard Tromp and Elmore, {James R} and Natzi Sakalihasan and Raymond Limet and Jean-Olivier Defraigne and Ferrell, {Robert E} and Antti Ronkainen and Ruigrok, {Ynte M} and Cisca Wijmenga and Grobbee, {Diederick E} and Shah, {Svati H} and Granger, {Christopher B} and Quyyumi, {Arshed A} and Viola Vaccarino and Patel, {Riyaz S} and Zafari, {A Maziar} and Levey, {Allan I} and Harland Austin and Domenico Girelli and Pignatti, {Pier Franco} and Oliviero Olivieri and Nicola Martinelli and Giovanni Malerba and Elisabetta Trabetti and Becker, {Lewis C} and Becker, {Diane M} and Reilly, {Muredach P} and Rader, {Daniel J} and Thomas Mueller and Benjamin Dieplinger and Meinhard Haltmayer and Sigitas Urbonavicius and Bengt Lindblad and Anders Gotts{\"a}ter and Eleonora Gaetani and Roberto Pola and Philip Wells and Marc Rodger and Melissa Forgie and Nicole Langlois and Javier Corral and Vicente Vasquez and Jordi Fontcuberta and Francisco Espa{\~n}a and Niels Grarup and Torben J{\o}rgensen and Witte, {Daniel R} and Torben Hansen and Oluf Pedersen and Aben, {Katja K} and {de Graaf}, Jacqueline and Suzanne Holewijn and Lasse Folkersen and Anders Franco-Cereceda and Per Eriksson and Collier, {David A} and Hreinn Stefansson and Valgerdur Steinthorsdottir and Thorunn Rafnar and Valdimarsson, {Einar M} and Magnadottir, {Hulda B} and Sigurlaug Sveinbjornsdottir and Isleifur Olafsson and Magnusson, {Magnus Karl} and Robert Palmason and Vilhelmina Haraldsdottir and Karl Andersen and Onundarson, {Pall T} and Gudmundur Thorgeirsson and Kiemeney, {Lambertus A} and Powell, {Janet T} and Carey, {David J} and Helena Kuivaniemi and Lindholt, {Jes S.} and Jones, {Gregory T} and Augustine Kong and Blankensteijn, {Jan D} and Matthiasson, {Stefan E} and Unnur Thorsteinsdottir and Kari Stefansson",
year = "2010",
month = aug,
day = "1",
doi = "10.1038/ng.622",
language = "English",
volume = "42",
pages = "692--7",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",
}
RIS
TY - JOUR
T1 - Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
AU - Gretarsdottir, Solveig
AU - Baas, Annette F
AU - Thorleifsson, Gudmar
AU - Holm, Hilma
AU - den Heijer, Martin
AU - de Vries, Jean-Paul P M
AU - Kranendonk, Steef E
AU - Zeebregts, Clark J A M
AU - van Sterkenburg, Steven M
AU - Geelkerken, Robert H
AU - van Rij, Andre M
AU - Williams, Michael J A
AU - Boll, Albert P M
AU - Kostic, Jelena P
AU - Jonasdottir, Adalbjorg
AU - Jonasdottir, Aslaug
AU - Walters, G Bragi
AU - Masson, Gisli
AU - Sulem, Patrick
AU - Saemundsdottir, Jona
AU - Mouy, Magali
AU - Magnusson, Kristinn P
AU - Tromp, Gerard
AU - Elmore, James R
AU - Sakalihasan, Natzi
AU - Limet, Raymond
AU - Defraigne, Jean-Olivier
AU - Ferrell, Robert E
AU - Ronkainen, Antti
AU - Ruigrok, Ynte M
AU - Wijmenga, Cisca
AU - Grobbee, Diederick E
AU - Shah, Svati H
AU - Granger, Christopher B
AU - Quyyumi, Arshed A
AU - Vaccarino, Viola
AU - Patel, Riyaz S
AU - Zafari, A Maziar
AU - Levey, Allan I
AU - Austin, Harland
AU - Girelli, Domenico
AU - Pignatti, Pier Franco
AU - Olivieri, Oliviero
AU - Martinelli, Nicola
AU - Malerba, Giovanni
AU - Trabetti, Elisabetta
AU - Becker, Lewis C
AU - Becker, Diane M
AU - Reilly, Muredach P
AU - Rader, Daniel J
AU - Mueller, Thomas
AU - Dieplinger, Benjamin
AU - Haltmayer, Meinhard
AU - Urbonavicius, Sigitas
AU - Lindblad, Bengt
AU - Gottsäter, Anders
AU - Gaetani, Eleonora
AU - Pola, Roberto
AU - Wells, Philip
AU - Rodger, Marc
AU - Forgie, Melissa
AU - Langlois, Nicole
AU - Corral, Javier
AU - Vasquez, Vicente
AU - Fontcuberta, Jordi
AU - España, Francisco
AU - Grarup, Niels
AU - Jørgensen, Torben
AU - Witte, Daniel R
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Aben, Katja K
AU - de Graaf, Jacqueline
AU - Holewijn, Suzanne
AU - Folkersen, Lasse
AU - Franco-Cereceda, Anders
AU - Eriksson, Per
AU - Collier, David A
AU - Stefansson, Hreinn
AU - Steinthorsdottir, Valgerdur
AU - Rafnar, Thorunn
AU - Valdimarsson, Einar M
AU - Magnadottir, Hulda B
AU - Sveinbjornsdottir, Sigurlaug
AU - Olafsson, Isleifur
AU - Magnusson, Magnus Karl
AU - Palmason, Robert
AU - Haraldsdottir, Vilhelmina
AU - Andersen, Karl
AU - Onundarson, Pall T
AU - Thorgeirsson, Gudmundur
AU - Kiemeney, Lambertus A
AU - Powell, Janet T
AU - Carey, David J
AU - Kuivaniemi, Helena
AU - Lindholt, Jes S.
AU - Jones, Gregory T
AU - Kong, Augustine
AU - Blankensteijn, Jan D
AU - Matthiasson, Stefan E
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
PY - 2010/8/1
Y1 - 2010/8/1
N2 - We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
AB - We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
KW - Alleles
KW - Aortic Aneurysm, Abdominal
KW - Base Sequence
KW - Disease Susceptibility
KW - Genome-Wide Association Study
KW - Humans
KW - Hypertension
KW - Iceland
KW - Myocardial Infarction
KW - Netherlands
KW - Odds Ratio
KW - Risk Factors
KW - ras GTPase-Activating Proteins
U2 - 10.1038/ng.622
DO - 10.1038/ng.622
M3 - Journal article
C2 - 20622881
VL - 42
SP - 692
EP - 697
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
