Human leukocyte antigen system associations in Malassezia-related skin diseases

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Human leukocyte antigen system associations in Malassezia-related skin diseases. / Lindsø Andersen, P.; Jemec, G. B.; Erikstrup, C.; Didriksen, M.; Dinh, K. M.; Mikkelsen, S.; Sørensen, E.; Nielsen, K. R.; Bruun, M. T.; Hjalgrim, H.; Hansen, T. F.; Sækmose, S. G.; Ostrowski, S. R.; Saunte, D. M.L.; Pedersen, O. B.; DBDS Genetic Consortium.

In: Archives of Dermatological Research, Vol. 315, 2023, p. 895–902.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Lindsø Andersen, P, Jemec, GB, Erikstrup, C, Didriksen, M, Dinh, KM, Mikkelsen, S, Sørensen, E, Nielsen, KR, Bruun, MT, Hjalgrim, H, Hansen, TF, Sækmose, SG, Ostrowski, SR, Saunte, DML, Pedersen, OB & DBDS Genetic Consortium 2023, 'Human leukocyte antigen system associations in Malassezia-related skin diseases', Archives of Dermatological Research, vol. 315, pp. 895–902. https://doi.org/10.1007/s00403-022-02454-9

APA

Lindsø Andersen, P., Jemec, G. B., Erikstrup, C., Didriksen, M., Dinh, K. M., Mikkelsen, S., Sørensen, E., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Hansen, T. F., Sækmose, S. G., Ostrowski, S. R., Saunte, D. M. L., Pedersen, O. B., & DBDS Genetic Consortium (2023). Human leukocyte antigen system associations in Malassezia-related skin diseases. Archives of Dermatological Research, 315, 895–902. https://doi.org/10.1007/s00403-022-02454-9

Vancouver

Lindsø Andersen P, Jemec GB, Erikstrup C, Didriksen M, Dinh KM, Mikkelsen S et al. Human leukocyte antigen system associations in Malassezia-related skin diseases. Archives of Dermatological Research. 2023;315:895–902. https://doi.org/10.1007/s00403-022-02454-9

Author

Lindsø Andersen, P. ; Jemec, G. B. ; Erikstrup, C. ; Didriksen, M. ; Dinh, K. M. ; Mikkelsen, S. ; Sørensen, E. ; Nielsen, K. R. ; Bruun, M. T. ; Hjalgrim, H. ; Hansen, T. F. ; Sækmose, S. G. ; Ostrowski, S. R. ; Saunte, D. M.L. ; Pedersen, O. B. ; DBDS Genetic Consortium. / Human leukocyte antigen system associations in Malassezia-related skin diseases. In: Archives of Dermatological Research. 2023 ; Vol. 315. pp. 895–902.

Bibtex

@article{9d425d615a9c4778b7aeb39c5e65a4ac,
title = "Human leukocyte antigen system associations in Malassezia-related skin diseases",
abstract = "Background: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods: Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09–1.31), C*01:02, OR 1.19 (95% CI: 1.08–1.32), C*06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85–0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.",
keywords = "Blood donors, Head and neck dermatitis, Major histocompatibility complex, Malassezia folliculitis, Pityriasis versicolor, Seborrheic dermatitis",
author = "{Linds{\o} Andersen}, P. and Jemec, {G. B.} and C. Erikstrup and M. Didriksen and Dinh, {K. M.} and S. Mikkelsen and E. S{\o}rensen and Nielsen, {K. R.} and Bruun, {M. T.} and H. Hjalgrim and Hansen, {T. F.} and S{\ae}kmose, {S. G.} and Ostrowski, {S. R.} and Saunte, {D. M.L.} and Pedersen, {O. B.} and {DBDS Genetic Consortium}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2023",
doi = "10.1007/s00403-022-02454-9",
language = "English",
volume = "315",
pages = "895–902",
journal = "Archiv f{\"u}r Dermatologische Forschung",
issn = "0340-3696",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Human leukocyte antigen system associations in Malassezia-related skin diseases

AU - Lindsø Andersen, P.

AU - Jemec, G. B.

AU - Erikstrup, C.

AU - Didriksen, M.

AU - Dinh, K. M.

AU - Mikkelsen, S.

AU - Sørensen, E.

AU - Nielsen, K. R.

AU - Bruun, M. T.

AU - Hjalgrim, H.

AU - Hansen, T. F.

AU - Sækmose, S. G.

AU - Ostrowski, S. R.

AU - Saunte, D. M.L.

AU - Pedersen, O. B.

AU - DBDS Genetic Consortium

N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2023

Y1 - 2023

N2 - Background: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods: Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09–1.31), C*01:02, OR 1.19 (95% CI: 1.08–1.32), C*06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85–0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.

AB - Background: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods: Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09–1.31), C*01:02, OR 1.19 (95% CI: 1.08–1.32), C*06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85–0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.

KW - Blood donors

KW - Head and neck dermatitis

KW - Major histocompatibility complex

KW - Malassezia folliculitis

KW - Pityriasis versicolor

KW - Seborrheic dermatitis

U2 - 10.1007/s00403-022-02454-9

DO - 10.1007/s00403-022-02454-9

M3 - Journal article

C2 - 36394635

AN - SCOPUS:85142281004

VL - 315

SP - 895

EP - 902

JO - Archiv für Dermatologische Forschung

JF - Archiv für Dermatologische Forschung

SN - 0340-3696

ER -

ID: 327944539