Human leukocyte antigen system associations in Malassezia-related skin diseases
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Human leukocyte antigen system associations in Malassezia-related skin diseases. / Lindsø Andersen, P.; Jemec, G. B.; Erikstrup, C.; Didriksen, M.; Dinh, K. M.; Mikkelsen, S.; Sørensen, E.; Nielsen, K. R.; Bruun, M. T.; Hjalgrim, H.; Hansen, T. F.; Sækmose, S. G.; Ostrowski, S. R.; Saunte, D. M.L.; Pedersen, O. B.; DBDS Genetic Consortium.
In: Archives of Dermatological Research, Vol. 315, 2023, p. 895–902.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Human leukocyte antigen system associations in Malassezia-related skin diseases
AU - Lindsø Andersen, P.
AU - Jemec, G. B.
AU - Erikstrup, C.
AU - Didriksen, M.
AU - Dinh, K. M.
AU - Mikkelsen, S.
AU - Sørensen, E.
AU - Nielsen, K. R.
AU - Bruun, M. T.
AU - Hjalgrim, H.
AU - Hansen, T. F.
AU - Sækmose, S. G.
AU - Ostrowski, S. R.
AU - Saunte, D. M.L.
AU - Pedersen, O. B.
AU - DBDS Genetic Consortium
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Background: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods: Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09–1.31), C*01:02, OR 1.19 (95% CI: 1.08–1.32), C*06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85–0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.
AB - Background: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD. Materials and methods: Participants in The Danish Blood Donor Study (2010–2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests. Results: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09–1.31), C*01:02, OR 1.19 (95% CI: 1.08–1.32), C*06:02, OR 1.14 (95% CI: 1.08–1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04–1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85–0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85–0.94). Conclusion: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.
KW - Blood donors
KW - Head and neck dermatitis
KW - Major histocompatibility complex
KW - Malassezia folliculitis
KW - Pityriasis versicolor
KW - Seborrheic dermatitis
U2 - 10.1007/s00403-022-02454-9
DO - 10.1007/s00403-022-02454-9
M3 - Journal article
C2 - 36394635
AN - SCOPUS:85142281004
VL - 315
SP - 895
EP - 902
JO - Archiv für Dermatologische Forschung
JF - Archiv für Dermatologische Forschung
SN - 0340-3696
ER -
ID: 327944539