Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication

Research output: Contribution to journalJournal articlepeer-review

Standard

Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes : Sex differences in symptomatology and prediction of future anti-depressive medication. / Mikkelsen, Christina; Larsen, Margit A.H.; Sørensen, Erik; Hansen, Thomas Folkmann; Mikkelsen, Susan; Erikstrup, Christian; Nielsen, Kaspar R.; Bruun, Mie T.; Hjalgrim, Henrik; Kessing, Lars V.; Werge, Thomas; Ullum, Henrik; Ostrowski, Sisse R.; Pedersen, Ole B.; Thørner, Lise W.; Didriksen, Maria.

In: Psychiatry Research, Vol. 318, 114944, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Mikkelsen, C, Larsen, MAH, Sørensen, E, Hansen, TF, Mikkelsen, S, Erikstrup, C, Nielsen, KR, Bruun, MT, Hjalgrim, H, Kessing, LV, Werge, T, Ullum, H, Ostrowski, SR, Pedersen, OB, Thørner, LW & Didriksen, M 2022, 'Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication', Psychiatry Research, vol. 318, 114944. https://doi.org/10.1016/j.psychres.2022.114944

APA

Mikkelsen, C., Larsen, M. A. H., Sørensen, E., Hansen, T. F., Mikkelsen, S., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Kessing, L. V., Werge, T., Ullum, H., Ostrowski, S. R., Pedersen, O. B., Thørner, L. W., & Didriksen, M. (2022). Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication. Psychiatry Research, 318, [114944]. https://doi.org/10.1016/j.psychres.2022.114944

Vancouver

Mikkelsen C, Larsen MAH, Sørensen E, Hansen TF, Mikkelsen S, Erikstrup C et al. Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication. Psychiatry Research. 2022;318. 114944. https://doi.org/10.1016/j.psychres.2022.114944

Author

Mikkelsen, Christina ; Larsen, Margit A.H. ; Sørensen, Erik ; Hansen, Thomas Folkmann ; Mikkelsen, Susan ; Erikstrup, Christian ; Nielsen, Kaspar R. ; Bruun, Mie T. ; Hjalgrim, Henrik ; Kessing, Lars V. ; Werge, Thomas ; Ullum, Henrik ; Ostrowski, Sisse R. ; Pedersen, Ole B. ; Thørner, Lise W. ; Didriksen, Maria. / Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes : Sex differences in symptomatology and prediction of future anti-depressive medication. In: Psychiatry Research. 2022 ; Vol. 318.

Bibtex

@article{af56109f99b745e3977b7fa9dfbf58c7,
title = "Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication",
abstract = "Major Depressive Disorder (MDD) is a heterogeneous disease, which displays sex differences in symptomatology. This study aimed to assess point prevalence of MDD in undiagnosed, healthy adults as well as sex differences in symptomatology and clarify if specific symptoms increased the later need for anti-depressive medication. The study included 51,658 blood donors. Depressive symptoms were assessed according to ICD-10 using the Major Depression Inventory. Demographics, previous MDD, anti-depressive medication were collected from questionnaires and population registers. Descriptive, Logistic and Cox regression analyses were conducted. In total, 1.15% participants met the criteria for MDD. Women were significantly more likely to experience {"}increased appetite{"} and less likely to experience “a feeling of life not worth living”, compared to men. MDD significantly associated with an increased hazard of later receiving a prescription for anti-depressive medication. The risk increased proportionally with increasing MDD severity. The two symptoms, “feeling that life is not worth living” and {"}trouble sleeping{"} were the strongest individual predictive symptoms of future anti-depressive medication in women and men, respectively. The results confirm findings in MDD patient groups. The diagnostic and prognostic value should be investigated further to address their potential as part of the clinical assessment.",
keywords = "Epidemiology, Mental health",
author = "Christina Mikkelsen and Larsen, {Margit A.H.} and Erik S{\o}rensen and Hansen, {Thomas Folkmann} and Susan Mikkelsen and Christian Erikstrup and Nielsen, {Kaspar R.} and Bruun, {Mie T.} and Henrik Hjalgrim and Kessing, {Lars V.} and Thomas Werge and Henrik Ullum and Ostrowski, {Sisse R.} and Pedersen, {Ole B.} and Th{\o}rner, {Lise W.} and Maria Didriksen",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.psychres.2022.114944",
language = "English",
volume = "318",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes

T2 - Sex differences in symptomatology and prediction of future anti-depressive medication

AU - Mikkelsen, Christina

AU - Larsen, Margit A.H.

AU - Sørensen, Erik

AU - Hansen, Thomas Folkmann

AU - Mikkelsen, Susan

AU - Erikstrup, Christian

AU - Nielsen, Kaspar R.

AU - Bruun, Mie T.

AU - Hjalgrim, Henrik

AU - Kessing, Lars V.

AU - Werge, Thomas

AU - Ullum, Henrik

AU - Ostrowski, Sisse R.

AU - Pedersen, Ole B.

AU - Thørner, Lise W.

AU - Didriksen, Maria

N1 - Publisher Copyright: © 2022

PY - 2022

Y1 - 2022

N2 - Major Depressive Disorder (MDD) is a heterogeneous disease, which displays sex differences in symptomatology. This study aimed to assess point prevalence of MDD in undiagnosed, healthy adults as well as sex differences in symptomatology and clarify if specific symptoms increased the later need for anti-depressive medication. The study included 51,658 blood donors. Depressive symptoms were assessed according to ICD-10 using the Major Depression Inventory. Demographics, previous MDD, anti-depressive medication were collected from questionnaires and population registers. Descriptive, Logistic and Cox regression analyses were conducted. In total, 1.15% participants met the criteria for MDD. Women were significantly more likely to experience "increased appetite" and less likely to experience “a feeling of life not worth living”, compared to men. MDD significantly associated with an increased hazard of later receiving a prescription for anti-depressive medication. The risk increased proportionally with increasing MDD severity. The two symptoms, “feeling that life is not worth living” and "trouble sleeping" were the strongest individual predictive symptoms of future anti-depressive medication in women and men, respectively. The results confirm findings in MDD patient groups. The diagnostic and prognostic value should be investigated further to address their potential as part of the clinical assessment.

AB - Major Depressive Disorder (MDD) is a heterogeneous disease, which displays sex differences in symptomatology. This study aimed to assess point prevalence of MDD in undiagnosed, healthy adults as well as sex differences in symptomatology and clarify if specific symptoms increased the later need for anti-depressive medication. The study included 51,658 blood donors. Depressive symptoms were assessed according to ICD-10 using the Major Depression Inventory. Demographics, previous MDD, anti-depressive medication were collected from questionnaires and population registers. Descriptive, Logistic and Cox regression analyses were conducted. In total, 1.15% participants met the criteria for MDD. Women were significantly more likely to experience "increased appetite" and less likely to experience “a feeling of life not worth living”, compared to men. MDD significantly associated with an increased hazard of later receiving a prescription for anti-depressive medication. The risk increased proportionally with increasing MDD severity. The two symptoms, “feeling that life is not worth living” and "trouble sleeping" were the strongest individual predictive symptoms of future anti-depressive medication in women and men, respectively. The results confirm findings in MDD patient groups. The diagnostic and prognostic value should be investigated further to address their potential as part of the clinical assessment.

KW - Epidemiology

KW - Mental health

U2 - 10.1016/j.psychres.2022.114944

DO - 10.1016/j.psychres.2022.114944

M3 - Journal article

C2 - 36402070

AN - SCOPUS:85141984603

VL - 318

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 114944

ER -

ID: 327322208