Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women

Research output: Contribution to journalJournal articlepeer-review

Standard

Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women. / Åkerström, Thorbjörn; Stolpe, Malene Norup; Widmer, Renate; Dejgaard, Thomas Fremming; Højberg, Jens M; Møller, Kirsten; Hansen, Jakob S; Trinh, Beckey; Holst, Jens Juul; Thomsen, Carsten; Pedersen, Bente Klarlund; Ellingsgaard, Helga.

In: Journal of the Endocrine Society, Vol. 6, No. 9, bvac111, 2022, p. 1-8.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Åkerström, T, Stolpe, MN, Widmer, R, Dejgaard, TF, Højberg, JM, Møller, K, Hansen, JS, Trinh, B, Holst, JJ, Thomsen, C, Pedersen, BK & Ellingsgaard, H 2022, 'Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women', Journal of the Endocrine Society, vol. 6, no. 9, bvac111, pp. 1-8. https://doi.org/10.1210/jendso/bvac111

APA

Åkerström, T., Stolpe, M. N., Widmer, R., Dejgaard, T. F., Højberg, J. M., Møller, K., Hansen, J. S., Trinh, B., Holst, J. J., Thomsen, C., Pedersen, B. K., & Ellingsgaard, H. (2022). Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women. Journal of the Endocrine Society, 6(9), 1-8. [bvac111]. https://doi.org/10.1210/jendso/bvac111

Vancouver

Åkerström T, Stolpe MN, Widmer R, Dejgaard TF, Højberg JM, Møller K et al. Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women. Journal of the Endocrine Society. 2022;6(9):1-8. bvac111. https://doi.org/10.1210/jendso/bvac111

Author

Åkerström, Thorbjörn ; Stolpe, Malene Norup ; Widmer, Renate ; Dejgaard, Thomas Fremming ; Højberg, Jens M ; Møller, Kirsten ; Hansen, Jakob S ; Trinh, Beckey ; Holst, Jens Juul ; Thomsen, Carsten ; Pedersen, Bente Klarlund ; Ellingsgaard, Helga. / Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women. In: Journal of the Endocrine Society. 2022 ; Vol. 6, No. 9. pp. 1-8.

Bibtex

@article{3b26dc36f0a54d2f8d51a4493f8f1904,
title = "Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women",
abstract = "Context and objective: Obesity and inactivity are risk factors for developing impaired glucose tolerance characterized by insulin resistance and reduced beta-cell function. The stimulatory effect of glucagon-like peptide 1 (GLP-1) on insulin secretion is also impaired in obese, inactive individuals. The aim of this study was to investigate whether endurance training influences beta-cell sensitivity to GLP-1. Participants and intervention: Twenty-four female participants, age 46 ± 2 years, body mass index 32.4 ± 0.9 kg/m2, and maximal oxygen consumption 24.7 ± 0.8 mL/kg/min participated in a 10-week exercise training study. Methods: Beta-cell sensitivity to GLP-1 was assessed in a subset of participants (n = 6) during a 120-minute hyperglycemic glucose clamp (8.5 mM) including a 1-hour GLP-1 (7-36 amide) infusion (0.4 pmol/kg/min). Changes in glucose tolerance, body composition, and cardiorespiratory fitness were assessed by oral glucose tolerance tests (OGTTs), dual-energy X-ray absorptiometry scans, magnetic resonance scans, and maximal oxygen consumption (VO2max) tests, respectively. Results: The c-peptide response to infusion of GLP-1 increased 28 ± 3% (P < 0.05) toward the end of the hyperglycemic clamp. The insulin response remained unchanged. Training improved glucose tolerance and reduced GLP-1, insulin, and glucagon levels during the OGTTs. Training increased VO2max (from 24.7 ± 0.8 to 27.0 ± 0.7 mL/kg/min; P < 0.05) and reduced visceral fat volume (from 4176 ± 265 to 3888 ± 266 cm3; P < 0.01). Conclusion: Along with improved glycemic control, endurance training improved beta-cell sensitivity to GLP-1 in overweight women. The study was deemed not to constitute a clinical trial and was not registered as such. ",
keywords = "Exercise, GLP-1 sensitivity, Obese",
author = "Thorbj{\"o}rn {\AA}kerstr{\"o}m and Stolpe, {Malene Norup} and Renate Widmer and Dejgaard, {Thomas Fremming} and H{\o}jberg, {Jens M} and Kirsten M{\o}ller and Hansen, {Jakob S} and Beckey Trinh and Holst, {Jens Juul} and Carsten Thomsen and Pedersen, {Bente Klarlund} and Helga Ellingsgaard",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s).",
year = "2022",
doi = "10.1210/jendso/bvac111",
language = "English",
volume = "6",
pages = "1--8",
journal = "Endocrine Research Communications",
issn = "0743-5800",
publisher = "Taylor & Francis",
number = "9",

}

RIS

TY - JOUR

T1 - Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women

AU - Åkerström, Thorbjörn

AU - Stolpe, Malene Norup

AU - Widmer, Renate

AU - Dejgaard, Thomas Fremming

AU - Højberg, Jens M

AU - Møller, Kirsten

AU - Hansen, Jakob S

AU - Trinh, Beckey

AU - Holst, Jens Juul

AU - Thomsen, Carsten

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

N1 - Publisher Copyright: © 2022 The Author(s).

PY - 2022

Y1 - 2022

N2 - Context and objective: Obesity and inactivity are risk factors for developing impaired glucose tolerance characterized by insulin resistance and reduced beta-cell function. The stimulatory effect of glucagon-like peptide 1 (GLP-1) on insulin secretion is also impaired in obese, inactive individuals. The aim of this study was to investigate whether endurance training influences beta-cell sensitivity to GLP-1. Participants and intervention: Twenty-four female participants, age 46 ± 2 years, body mass index 32.4 ± 0.9 kg/m2, and maximal oxygen consumption 24.7 ± 0.8 mL/kg/min participated in a 10-week exercise training study. Methods: Beta-cell sensitivity to GLP-1 was assessed in a subset of participants (n = 6) during a 120-minute hyperglycemic glucose clamp (8.5 mM) including a 1-hour GLP-1 (7-36 amide) infusion (0.4 pmol/kg/min). Changes in glucose tolerance, body composition, and cardiorespiratory fitness were assessed by oral glucose tolerance tests (OGTTs), dual-energy X-ray absorptiometry scans, magnetic resonance scans, and maximal oxygen consumption (VO2max) tests, respectively. Results: The c-peptide response to infusion of GLP-1 increased 28 ± 3% (P < 0.05) toward the end of the hyperglycemic clamp. The insulin response remained unchanged. Training improved glucose tolerance and reduced GLP-1, insulin, and glucagon levels during the OGTTs. Training increased VO2max (from 24.7 ± 0.8 to 27.0 ± 0.7 mL/kg/min; P < 0.05) and reduced visceral fat volume (from 4176 ± 265 to 3888 ± 266 cm3; P < 0.01). Conclusion: Along with improved glycemic control, endurance training improved beta-cell sensitivity to GLP-1 in overweight women. The study was deemed not to constitute a clinical trial and was not registered as such.

AB - Context and objective: Obesity and inactivity are risk factors for developing impaired glucose tolerance characterized by insulin resistance and reduced beta-cell function. The stimulatory effect of glucagon-like peptide 1 (GLP-1) on insulin secretion is also impaired in obese, inactive individuals. The aim of this study was to investigate whether endurance training influences beta-cell sensitivity to GLP-1. Participants and intervention: Twenty-four female participants, age 46 ± 2 years, body mass index 32.4 ± 0.9 kg/m2, and maximal oxygen consumption 24.7 ± 0.8 mL/kg/min participated in a 10-week exercise training study. Methods: Beta-cell sensitivity to GLP-1 was assessed in a subset of participants (n = 6) during a 120-minute hyperglycemic glucose clamp (8.5 mM) including a 1-hour GLP-1 (7-36 amide) infusion (0.4 pmol/kg/min). Changes in glucose tolerance, body composition, and cardiorespiratory fitness were assessed by oral glucose tolerance tests (OGTTs), dual-energy X-ray absorptiometry scans, magnetic resonance scans, and maximal oxygen consumption (VO2max) tests, respectively. Results: The c-peptide response to infusion of GLP-1 increased 28 ± 3% (P < 0.05) toward the end of the hyperglycemic clamp. The insulin response remained unchanged. Training improved glucose tolerance and reduced GLP-1, insulin, and glucagon levels during the OGTTs. Training increased VO2max (from 24.7 ± 0.8 to 27.0 ± 0.7 mL/kg/min; P < 0.05) and reduced visceral fat volume (from 4176 ± 265 to 3888 ± 266 cm3; P < 0.01). Conclusion: Along with improved glycemic control, endurance training improved beta-cell sensitivity to GLP-1 in overweight women. The study was deemed not to constitute a clinical trial and was not registered as such.

KW - Exercise

KW - GLP-1 sensitivity

KW - Obese

U2 - 10.1210/jendso/bvac111

DO - 10.1210/jendso/bvac111

M3 - Journal article

C2 - 35935071

AN - SCOPUS:85136296165

VL - 6

SP - 1

EP - 8

JO - Endocrine Research Communications

JF - Endocrine Research Communications

SN - 0743-5800

IS - 9

M1 - bvac111

ER -

ID: 318456551