Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests

Research output: Contribution to journalJournal articlepeer-review

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Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests. / Veedfald, Simon; Rehfeld, Jens Frederik; van Hall, Gerrit; Svendsen, Lars Bo; Holst, Jens Juul.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 107, No. 1, 2022, p. e188-e204.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Veedfald, S, Rehfeld, JF, van Hall, G, Svendsen, LB & Holst, JJ 2022, 'Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests', Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 1, pp. e188-e204. https://doi.org/10.1210/clinem/dgab610

APA

Veedfald, S., Rehfeld, J. F., van Hall, G., Svendsen, L. B., & Holst, J. J. (2022). Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests. Journal of Clinical Endocrinology and Metabolism, 107(1), e188-e204. https://doi.org/10.1210/clinem/dgab610

Vancouver

Veedfald S, Rehfeld JF, van Hall G, Svendsen LB, Holst JJ. Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests. Journal of Clinical Endocrinology and Metabolism. 2022;107(1):e188-e204. https://doi.org/10.1210/clinem/dgab610

Author

Veedfald, Simon ; Rehfeld, Jens Frederik ; van Hall, Gerrit ; Svendsen, Lars Bo ; Holst, Jens Juul. / Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests. In: Journal of Clinical Endocrinology and Metabolism. 2022 ; Vol. 107, No. 1. pp. e188-e204.

Bibtex

@article{2951bfe6e7544d5e848d02adb4d11c43,
title = "Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests",
abstract = "CONTEXT: Entero-pancreatic hormone secretion has been reported during the pre-absorptive cephalic and gastric meal phases, but never with a blood sampling frequency providing a temporal resolution that allows close scrutiny and correlations with gastric emptying and glucose-absorption.OBJECTIVE: We hypothesized that entero-pancreatic hormone secretion after nutrient ingestion would be rapid and correlate with gastric emptying and glucose absorption.DESIGN AND SETTING: Two visits in a clinical research facility.PARTICIPANTS: Ten healthy young men.INTERVENTIONS: A 75g glucose drink (OG) and a liquid mixed meal (LMM) were ingested (t 0-2 min) on separate days. Acetaminophen and 3-O-methyl-D-glucopyranose (3-OMG) were added to the drinks to evaluate gastric emptying and glucose absorption, respectively. Arterialized venous blood was sampled (t -30,-20,-18,-16,-14,-12,-10,-8,-6,-4,-2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min).MAIN OUTCOME MEASURES: Plasma glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), gastrin, cholecystokinin (CCK), glucagon, pancreatic polypeptide (PP), 3-OMG and glucose. Serum insulin, C-peptide and acetaminophen.RESULTS: Acetaminophen increased 8min after OG(p<0.001) and LMM(p<0.05). 3-OMG; 8min after LMM(p<0.0001), 10min after OG(p=0.04). PP; 4min after LMM(p<0.03). Gastrin; 6min after LMM(p<0.003) and OG(p<0.003). CCK; 6min after LMM(p=0.0001). GIP; 8min after OG(p<0.05) and LMM(p<0.03). Glucose; 8min after OG(p<0.001), 12min after LMM(p<0.02). GLP-1; 12min after OG(p<0.01), 10min after LMM (p<0.01).. Insulin; 12min after LMM(p=0.02) and OG(p=0.002). C-peptide; 12min after OG(p=0.002) and LMM(p=0.04).CONCLUSIONS: Early postprandial hormone responses show characteristic differences with regards to timing and amplitude, but also great individual differences. This should be considered when interpreting mean responses and designing study protocols.CLINICALTRIALS.GOV NUMBER: NCT03543423.",
author = "Simon Veedfald and Rehfeld, {Jens Frederik} and {van Hall}, Gerrit and Svendsen, {Lars Bo} and Holst, {Jens Juul}",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1210/clinem/dgab610",
language = "English",
volume = "107",
pages = "e188--e204",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests

AU - Veedfald, Simon

AU - Rehfeld, Jens Frederik

AU - van Hall, Gerrit

AU - Svendsen, Lars Bo

AU - Holst, Jens Juul

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - CONTEXT: Entero-pancreatic hormone secretion has been reported during the pre-absorptive cephalic and gastric meal phases, but never with a blood sampling frequency providing a temporal resolution that allows close scrutiny and correlations with gastric emptying and glucose-absorption.OBJECTIVE: We hypothesized that entero-pancreatic hormone secretion after nutrient ingestion would be rapid and correlate with gastric emptying and glucose absorption.DESIGN AND SETTING: Two visits in a clinical research facility.PARTICIPANTS: Ten healthy young men.INTERVENTIONS: A 75g glucose drink (OG) and a liquid mixed meal (LMM) were ingested (t 0-2 min) on separate days. Acetaminophen and 3-O-methyl-D-glucopyranose (3-OMG) were added to the drinks to evaluate gastric emptying and glucose absorption, respectively. Arterialized venous blood was sampled (t -30,-20,-18,-16,-14,-12,-10,-8,-6,-4,-2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min).MAIN OUTCOME MEASURES: Plasma glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), gastrin, cholecystokinin (CCK), glucagon, pancreatic polypeptide (PP), 3-OMG and glucose. Serum insulin, C-peptide and acetaminophen.RESULTS: Acetaminophen increased 8min after OG(p<0.001) and LMM(p<0.05). 3-OMG; 8min after LMM(p<0.0001), 10min after OG(p=0.04). PP; 4min after LMM(p<0.03). Gastrin; 6min after LMM(p<0.003) and OG(p<0.003). CCK; 6min after LMM(p=0.0001). GIP; 8min after OG(p<0.05) and LMM(p<0.03). Glucose; 8min after OG(p<0.001), 12min after LMM(p<0.02). GLP-1; 12min after OG(p<0.01), 10min after LMM (p<0.01).. Insulin; 12min after LMM(p=0.02) and OG(p=0.002). C-peptide; 12min after OG(p=0.002) and LMM(p=0.04).CONCLUSIONS: Early postprandial hormone responses show characteristic differences with regards to timing and amplitude, but also great individual differences. This should be considered when interpreting mean responses and designing study protocols.CLINICALTRIALS.GOV NUMBER: NCT03543423.

AB - CONTEXT: Entero-pancreatic hormone secretion has been reported during the pre-absorptive cephalic and gastric meal phases, but never with a blood sampling frequency providing a temporal resolution that allows close scrutiny and correlations with gastric emptying and glucose-absorption.OBJECTIVE: We hypothesized that entero-pancreatic hormone secretion after nutrient ingestion would be rapid and correlate with gastric emptying and glucose absorption.DESIGN AND SETTING: Two visits in a clinical research facility.PARTICIPANTS: Ten healthy young men.INTERVENTIONS: A 75g glucose drink (OG) and a liquid mixed meal (LMM) were ingested (t 0-2 min) on separate days. Acetaminophen and 3-O-methyl-D-glucopyranose (3-OMG) were added to the drinks to evaluate gastric emptying and glucose absorption, respectively. Arterialized venous blood was sampled (t -30,-20,-18,-16,-14,-12,-10,-8,-6,-4,-2, 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 30 min).MAIN OUTCOME MEASURES: Plasma glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), gastrin, cholecystokinin (CCK), glucagon, pancreatic polypeptide (PP), 3-OMG and glucose. Serum insulin, C-peptide and acetaminophen.RESULTS: Acetaminophen increased 8min after OG(p<0.001) and LMM(p<0.05). 3-OMG; 8min after LMM(p<0.0001), 10min after OG(p=0.04). PP; 4min after LMM(p<0.03). Gastrin; 6min after LMM(p<0.003) and OG(p<0.003). CCK; 6min after LMM(p=0.0001). GIP; 8min after OG(p<0.05) and LMM(p<0.03). Glucose; 8min after OG(p<0.001), 12min after LMM(p<0.02). GLP-1; 12min after OG(p<0.01), 10min after LMM (p<0.01).. Insulin; 12min after LMM(p=0.02) and OG(p=0.002). C-peptide; 12min after OG(p=0.002) and LMM(p=0.04).CONCLUSIONS: Early postprandial hormone responses show characteristic differences with regards to timing and amplitude, but also great individual differences. This should be considered when interpreting mean responses and designing study protocols.CLINICALTRIALS.GOV NUMBER: NCT03543423.

U2 - 10.1210/clinem/dgab610

DO - 10.1210/clinem/dgab610

M3 - Journal article

C2 - 34479362

VL - 107

SP - e188-e204

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 1

ER -

ID: 279259937