Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial

Research output: Contribution to journalJournal articlepeer-review

Standard

Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY : A human-randomized cross-over trial. / Brodersen, Katrine; Mose, Maike; Ramer Mikkelsen, Ulla; Jørgensen, Jens Otto Lunde; Festersen Nielsen, Michael; Møller, Niels; Wegeberg, Anne-Marie; Brock, Christina; Hartmann, Bolette; Holst, Jens Juul; Rittig, Nikolaj.

In: Physiological Reports, Vol. 10, No. 18, e15462, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Brodersen, K, Mose, M, Ramer Mikkelsen, U, Jørgensen, JOL, Festersen Nielsen, M, Møller, N, Wegeberg, A-M, Brock, C, Hartmann, B, Holst, JJ & Rittig, N 2022, 'Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial', Physiological Reports, vol. 10, no. 18, e15462. https://doi.org/10.14814/phy2.15462

APA

Brodersen, K., Mose, M., Ramer Mikkelsen, U., Jørgensen, J. O. L., Festersen Nielsen, M., Møller, N., Wegeberg, A-M., Brock, C., Hartmann, B., Holst, J. J., & Rittig, N. (2022). Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial. Physiological Reports, 10(18), [e15462]. https://doi.org/10.14814/phy2.15462

Vancouver

Brodersen K, Mose M, Ramer Mikkelsen U, Jørgensen JOL, Festersen Nielsen M, Møller N et al. Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial. Physiological Reports. 2022;10(18). e15462. https://doi.org/10.14814/phy2.15462

Author

Brodersen, Katrine ; Mose, Maike ; Ramer Mikkelsen, Ulla ; Jørgensen, Jens Otto Lunde ; Festersen Nielsen, Michael ; Møller, Niels ; Wegeberg, Anne-Marie ; Brock, Christina ; Hartmann, Bolette ; Holst, Jens Juul ; Rittig, Nikolaj. / Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY : A human-randomized cross-over trial. In: Physiological Reports. 2022 ; Vol. 10, No. 18.

Bibtex

@article{5879c693df9f4774bb03bd7dc9a21d59,
title = "Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial",
abstract = "Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.",
keywords = "Cross-Over Studies, Gastrointestinal Hormones, Gastrointestinal Motility, Glucagon-Like Peptide 1, Humans, Inflammation, Lipopolysaccharides, Male, Nausea/chemically induced, Peptide YY",
author = "Katrine Brodersen and Maike Mose and {Ramer Mikkelsen}, Ulla and J{\o}rgensen, {Jens Otto Lunde} and {Festersen Nielsen}, Michael and Niels M{\o}ller and Anne-Marie Wegeberg and Christina Brock and Bolette Hartmann and Holst, {Jens Juul} and Nikolaj Rittig",
note = "{\textcopyright} 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.",
year = "2022",
doi = "10.14814/phy2.15462",
language = "English",
volume = "10",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "18",

}

RIS

TY - JOUR

T1 - Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY

T2 - A human-randomized cross-over trial

AU - Brodersen, Katrine

AU - Mose, Maike

AU - Ramer Mikkelsen, Ulla

AU - Jørgensen, Jens Otto Lunde

AU - Festersen Nielsen, Michael

AU - Møller, Niels

AU - Wegeberg, Anne-Marie

AU - Brock, Christina

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Rittig, Nikolaj

N1 - © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

PY - 2022

Y1 - 2022

N2 - Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.

AB - Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI.

KW - Cross-Over Studies

KW - Gastrointestinal Hormones

KW - Gastrointestinal Motility

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Inflammation

KW - Lipopolysaccharides

KW - Male

KW - Nausea/chemically induced

KW - Peptide YY

U2 - 10.14814/phy2.15462

DO - 10.14814/phy2.15462

M3 - Journal article

C2 - 36117310

VL - 10

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 18

M1 - e15462

ER -

ID: 320663611