Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain
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Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain. / Schmidt, Lasse Hartmann; Aa, Jesper Stensig; Hartmann, Bolette; Madsen, Gunvor Iben; Qvist, Niels; Ellebæk, Mark Bremholm.
In: BMC Gastroenterology, Vol. 22, No. 1, 349, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain
AU - Schmidt, Lasse Hartmann
AU - Aa, Jesper Stensig
AU - Hartmann, Bolette
AU - Madsen, Gunvor Iben
AU - Qvist, Niels
AU - Ellebæk, Mark Bremholm
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Background: To investigate the effects of a reversed segment of the distal small intestine to improve weight gain in an experimental short bowel syndrome (SBS) model in piglets. Methods: Twenty-four piglets underwent resection of 70% of the distal small intestine. In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25 cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28. Results: The group with reversal of small intestine had a significant lower weight gain at 5.26 ± 3.39 kg (mean ± SD) compared to the control group with 11.14 ± 3.83 kg (p < 0.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group. Conclusions: Treatment of short bowel syndrome with a reversed jejunal segment of 25 cm had a detrimental effect on the weight gain.
AB - Background: To investigate the effects of a reversed segment of the distal small intestine to improve weight gain in an experimental short bowel syndrome (SBS) model in piglets. Methods: Twenty-four piglets underwent resection of 70% of the distal small intestine. In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25 cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28. Results: The group with reversal of small intestine had a significant lower weight gain at 5.26 ± 3.39 kg (mean ± SD) compared to the control group with 11.14 ± 3.83 kg (p < 0.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group. Conclusions: Treatment of short bowel syndrome with a reversed jejunal segment of 25 cm had a detrimental effect on the weight gain.
KW - GIP
KW - GLP-2
KW - Segmental reversal
KW - Short bowel syndrome
KW - Short gut syndrome
U2 - 10.1186/s12876-022-02418-3
DO - 10.1186/s12876-022-02418-3
M3 - Journal article
C2 - 35858830
AN - SCOPUS:85134396714
VL - 22
JO - B M C Gastroenterology
JF - B M C Gastroenterology
SN - 1471-230X
IS - 1
M1 - 349
ER -
ID: 314902986