Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Research output: Contribution to journal › Journal article › Research › peer-review

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Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. / Maqdasy, Salwan; Lecoutre, Simon; Renzi, Gianluca; Frendo-Cumbo, Scott; Rizo-Roca, David; Moritz, Thomas; Juvany, Marta; Hodek, Ondrej; Gao, Hui; Couchet, Morgane; Witting, Michael; Kerr, Alastair; Bergo, Martin O.; Choudhury, Robin P.; Aouadi, Myriam; Zierath, Juleen R.; Krook, Anna; Mejhert, Niklas; Rydén, Mikael.

In: Nature Metabolism, Vol. 4, 2022, p. 190-202.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Maqdasy, S, Lecoutre, S, Renzi, G, Frendo-Cumbo, S, Rizo-Roca, D, Moritz, T, Juvany, M, Hodek, O, Gao, H, Couchet, M, Witting, M, Kerr, A, Bergo, MO, Choudhury, RP, Aouadi, M, Zierath, JR, Krook, A, Mejhert, N & Rydén, M 2022, 'Impaired phosphocreatine metabolism in white adipocytes promotes inflammation', Nature Metabolism, vol. 4, pp. 190-202. https://doi.org/10.1038/s42255-022-00525-9

APA

Maqdasy, S., Lecoutre, S., Renzi, G., Frendo-Cumbo, S., Rizo-Roca, D., Moritz, T., Juvany, M., Hodek, O., Gao, H., Couchet, M., Witting, M., Kerr, A., Bergo, M. O., Choudhury, R. P., Aouadi, M., Zierath, J. R., Krook, A., Mejhert, N., & Rydén, M. (2022). Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature Metabolism, 4, 190-202. https://doi.org/10.1038/s42255-022-00525-9

Vancouver

Maqdasy S, Lecoutre S, Renzi G, Frendo-Cumbo S, Rizo-Roca D, Moritz T et al. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature Metabolism. 2022;4:190-202. https://doi.org/10.1038/s42255-022-00525-9

Author

Maqdasy, Salwan ; Lecoutre, Simon ; Renzi, Gianluca ; Frendo-Cumbo, Scott ; Rizo-Roca, David ; Moritz, Thomas ; Juvany, Marta ; Hodek, Ondrej ; Gao, Hui ; Couchet, Morgane ; Witting, Michael ; Kerr, Alastair ; Bergo, Martin O. ; Choudhury, Robin P. ; Aouadi, Myriam ; Zierath, Juleen R. ; Krook, Anna ; Mejhert, Niklas ; Rydén, Mikael. / Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. In: Nature Metabolism. 2022 ; Vol. 4. pp. 190-202.

Bibtex

@article{ad1590d63b394c4991a576d8d8a69e35,
title = "Impaired phosphocreatine metabolism in white adipocytes promotes inflammation",
abstract = "The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction.",
author = "Salwan Maqdasy and Simon Lecoutre and Gianluca Renzi and Scott Frendo-Cumbo and David Rizo-Roca and Thomas Moritz and Marta Juvany and Ondrej Hodek and Hui Gao and Morgane Couchet and Michael Witting and Alastair Kerr and Bergo, {Martin O.} and Choudhury, {Robin P.} and Myriam Aouadi and Zierath, {Juleen R.} and Anna Krook and Niklas Mejhert and Mikael Ryd{\'e}n",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s42255-022-00525-9",
language = "English",
volume = "4",
pages = "190--202",
journal = "Nature Metabolism",
issn = "2522-5812",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

AU - Maqdasy, Salwan

AU - Lecoutre, Simon

AU - Renzi, Gianluca

AU - Frendo-Cumbo, Scott

AU - Rizo-Roca, David

AU - Moritz, Thomas

AU - Juvany, Marta

AU - Hodek, Ondrej

AU - Gao, Hui

AU - Couchet, Morgane

AU - Witting, Michael

AU - Kerr, Alastair

AU - Bergo, Martin O.

AU - Choudhury, Robin P.

AU - Aouadi, Myriam

AU - Zierath, Juleen R.

AU - Krook, Anna

AU - Mejhert, Niklas

AU - Rydén, Mikael

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction.

AB - The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction.

U2 - 10.1038/s42255-022-00525-9

DO - 10.1038/s42255-022-00525-9

M3 - Journal article

C2 - 35165448

AN - SCOPUS:85124732151

VL - 4

SP - 190

EP - 202

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

ER -

ID: 298646001