Integration of molecular profiles in a longitudinal wellness profiling cohort

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Documents

  • Abdellah Tebani
  • Anders Gummesson
  • Wen Zhong
  • Ina Schuppe Koistinen
  • Tadepally Lakshmikanth
  • Lisa M. Olsson
  • Fredrik Boulund
  • Maja Neiman
  • Hans Stenlund
  • Cecilia Hellström
  • Max J. Karlsson
  • Muhammad Arif
  • Tea Dodig-Crnković
  • Adil Mardinoglu
  • Sunjae Lee
  • Cheng Zhang
  • Yang Chen
  • Axel Olin
  • Jaromir Mikes
  • Hanna Danielsson
  • Kalle von Feilitzen
  • Per Anders Jansson
  • Oskar Angerås
  • Mikael Huss
  • Sanela Kjellqvist
  • Jacob Odeberg
  • Fredrik Edfors
  • Valentina Tremaroli
  • Björn Forsström
  • Jochen M. Schwenk
  • Peter Nilsson
  • Fredrik Bäckhed
  • Lars Engstrand
  • Petter Brodin
  • Göran Bergström
  • Mathias Uhlen
  • Linn Fagerberg

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

Original languageEnglish
Article number4487
JournalNature Communications
Volume11
Issue number1
Number of pages14
ISSN2041-1723
DOIs
Publication statusPublished - 2020

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