Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

Research output: Contribution to journalJournal articlepeer-review

Standard

Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration. / Mikkelsen, Randi Bonke; Arora, Tulika; Trošt, Kajetan; Dmytriyeva, Oksana; Jensen, Sune Kjærsgaard; Meijnikman, Abraham Stijn; Olofsson, Louise Elisabeth; Lappa, Dimitra; Aydin, Ömrüm; Nielsen, Jens; Gerdes, Victor; Moritz, Thomas; van de Laar, Arnold; de Brauw, Maurits; Nieuwdorp, Max; Hjorth, Siv Annegrethe; Schwartz, Thue Walter; Bäckhed, Fredrik.

In: iScience, Vol. 25, No. 12, 105683, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Mikkelsen, RB, Arora, T, Trošt, K, Dmytriyeva, O, Jensen, SK, Meijnikman, AS, Olofsson, LE, Lappa, D, Aydin, Ö, Nielsen, J, Gerdes, V, Moritz, T, van de Laar, A, de Brauw, M, Nieuwdorp, M, Hjorth, SA, Schwartz, TW & Bäckhed, F 2022, 'Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration', iScience, vol. 25, no. 12, 105683. https://doi.org/10.1016/j.isci.2022.105683

APA

Mikkelsen, R. B., Arora, T., Trošt, K., Dmytriyeva, O., Jensen, S. K., Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, T., van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, S. A., Schwartz, T. W., & Bäckhed, F. (2022). Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration. iScience, 25(12), [105683]. https://doi.org/10.1016/j.isci.2022.105683

Vancouver

Mikkelsen RB, Arora T, Trošt K, Dmytriyeva O, Jensen SK, Meijnikman AS et al. Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration. iScience. 2022;25(12). 105683. https://doi.org/10.1016/j.isci.2022.105683

Author

Mikkelsen, Randi Bonke ; Arora, Tulika ; Trošt, Kajetan ; Dmytriyeva, Oksana ; Jensen, Sune Kjærsgaard ; Meijnikman, Abraham Stijn ; Olofsson, Louise Elisabeth ; Lappa, Dimitra ; Aydin, Ömrüm ; Nielsen, Jens ; Gerdes, Victor ; Moritz, Thomas ; van de Laar, Arnold ; de Brauw, Maurits ; Nieuwdorp, Max ; Hjorth, Siv Annegrethe ; Schwartz, Thue Walter ; Bäckhed, Fredrik. / Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration. In: iScience. 2022 ; Vol. 25, No. 12.

Bibtex

@article{b1dbceb73b964865af7b54e58a22073a,
title = "Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration",
abstract = "Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes immune cell recruitment to adipose tissue, which was associated with adipose inflammation and increased fasting insulin levels. Furthermore, we demonstrate that 3-hydroxydecanoate stimulates migration of primary human and mouse neutrophils, but not monocytes, through GPR84 and Gαi signaling in vitro. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes.",
keywords = "Cell biology, Immunology, Pathophysiology",
author = "Mikkelsen, {Randi Bonke} and Tulika Arora and Kajetan Tro{\v s}t and Oksana Dmytriyeva and Jensen, {Sune Kj{\ae}rsgaard} and Meijnikman, {Abraham Stijn} and Olofsson, {Louise Elisabeth} and Dimitra Lappa and {\"O}mr{\"u}m Aydin and Jens Nielsen and Victor Gerdes and Thomas Moritz and {van de Laar}, Arnold and {de Brauw}, Maurits and Max Nieuwdorp and Hjorth, {Siv Annegrethe} and Schwartz, {Thue Walter} and Fredrik B{\"a}ckhed",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.isci.2022.105683",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration

AU - Mikkelsen, Randi Bonke

AU - Arora, Tulika

AU - Trošt, Kajetan

AU - Dmytriyeva, Oksana

AU - Jensen, Sune Kjærsgaard

AU - Meijnikman, Abraham Stijn

AU - Olofsson, Louise Elisabeth

AU - Lappa, Dimitra

AU - Aydin, Ömrüm

AU - Nielsen, Jens

AU - Gerdes, Victor

AU - Moritz, Thomas

AU - van de Laar, Arnold

AU - de Brauw, Maurits

AU - Nieuwdorp, Max

AU - Hjorth, Siv Annegrethe

AU - Schwartz, Thue Walter

AU - Bäckhed, Fredrik

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes immune cell recruitment to adipose tissue, which was associated with adipose inflammation and increased fasting insulin levels. Furthermore, we demonstrate that 3-hydroxydecanoate stimulates migration of primary human and mouse neutrophils, but not monocytes, through GPR84 and Gαi signaling in vitro. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes.

AB - Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes immune cell recruitment to adipose tissue, which was associated with adipose inflammation and increased fasting insulin levels. Furthermore, we demonstrate that 3-hydroxydecanoate stimulates migration of primary human and mouse neutrophils, but not monocytes, through GPR84 and Gαi signaling in vitro. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes.

KW - Cell biology

KW - Immunology

KW - Pathophysiology

U2 - 10.1016/j.isci.2022.105683

DO - 10.1016/j.isci.2022.105683

M3 - Journal article

C2 - 36561890

AN - SCOPUS:85143727985

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 12

M1 - 105683

ER -

ID: 329709029