A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. / Guo, Yanjun; Rist, Pamela M.; Daghlas, Iyas; Giulianini, Franco; Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S.; Palta, Priit; Esko, Tonu; Pers, Tune H.; Farh, Kai How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A.; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M.; Kallela, Mikko; Freilinger, Tobias M.; Ran, Caroline; Gordon, Scott G.; Stam, Anine H.; Steinberg, Stacy; Borck, Guntram; Koiranen, Markku; Quaye, Lydia; Adams, Hieab H.H.; Lehtimäki, Terho; Sarin, Antti Pekka; Wedenoja, Juho; Hinds, David A.; Buring, Julie E.; Schürks, Markus; Ridker, Paul M.; Hrafnsdottir, Maria Gudlaug; Stefansson, Hreinn; Ring, Susan M.; Hottenga, Jouke Jan; Penninx, Brenda W.J.H.; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari; Vepsäläinen, Salli; Malik, Rainer; Christensen, Anne Francke; Hansen, Thomas Folkmann; Werge, Thomas; Olesen, Jes; The International Headache Genetics Consortium; the 23andMe Research Team.

In: Nature Communications, Vol. 11, No. 1, 3368, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guo, Y, Rist, PM, Daghlas, I, Giulianini, F, Gormley, P, Anttila, V, Winsvold, BS, Palta, P, Esko, T, Pers, TH, Farh, KH, Cuenca-Leon, E, Muona, M, Furlotte, NA, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, GM, Kallela, M, Freilinger, TM, Ran, C, Gordon, SG, Stam, AH, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, HHH, Lehtimäki, T, Sarin, AP, Wedenoja, J, Hinds, DA, Buring, JE, Schürks, M, Ridker, PM, Hrafnsdottir, MG, Stefansson, H, Ring, SM, Hottenga, JJ, Penninx, BWJH, Färkkilä, M, Artto, V, Kaunisto, M, Vepsäläinen, S, Malik, R, Christensen, AF, Hansen, TF, Werge, T, Olesen, J, The International Headache Genetics Consortium & the 23andMe Research Team 2020, 'A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine', Nature Communications, vol. 11, no. 1, 3368. https://doi.org/10.1038/s41467-020-17002-0

APA

Guo, Y., Rist, P. M., Daghlas, I., Giulianini, F., Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G. M., ... the 23andMe Research Team (2020). A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Nature Communications, 11(1), [3368]. https://doi.org/10.1038/s41467-020-17002-0

Vancouver

Guo Y, Rist PM, Daghlas I, Giulianini F, Gormley P, Anttila V et al. A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Nature Communications. 2020;11(1). 3368. https://doi.org/10.1038/s41467-020-17002-0

Author

Guo, Yanjun ; Rist, Pamela M. ; Daghlas, Iyas ; Giulianini, Franco ; Gormley, Padhraig ; Anttila, Verneri ; Winsvold, Bendik S. ; Palta, Priit ; Esko, Tonu ; Pers, Tune H. ; Farh, Kai How ; Cuenca-Leon, Ester ; Muona, Mikko ; Furlotte, Nicholas A. ; Kurth, Tobias ; Ingason, Andres ; McMahon, George ; Ligthart, Lannie ; Terwindt, Gisela M. ; Kallela, Mikko ; Freilinger, Tobias M. ; Ran, Caroline ; Gordon, Scott G. ; Stam, Anine H. ; Steinberg, Stacy ; Borck, Guntram ; Koiranen, Markku ; Quaye, Lydia ; Adams, Hieab H.H. ; Lehtimäki, Terho ; Sarin, Antti Pekka ; Wedenoja, Juho ; Hinds, David A. ; Buring, Julie E. ; Schürks, Markus ; Ridker, Paul M. ; Hrafnsdottir, Maria Gudlaug ; Stefansson, Hreinn ; Ring, Susan M. ; Hottenga, Jouke Jan ; Penninx, Brenda W.J.H. ; Färkkilä, Markus ; Artto, Ville ; Kaunisto, Mari ; Vepsäläinen, Salli ; Malik, Rainer ; Christensen, Anne Francke ; Hansen, Thomas Folkmann ; Werge, Thomas ; Olesen, Jes ; The International Headache Genetics Consortium ; the 23andMe Research Team. / A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{aa5883995ee64a528799420ed5361265,
title = "A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine",
abstract = "Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15–1.25]/10 mmHg; P = 5.57 × 10−25) on migraine than SBP (1.05 [1.03–1.07]/10 mmHg; P = 2.60 × 10−07) and a corresponding opposite effect for PP (0.92 [0.88–0.95]/10 mmHg; P = 3.65 × 10−07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.",
author = "Yanjun Guo and Rist, {Pamela M.} and Iyas Daghlas and Franco Giulianini and Padhraig Gormley and Verneri Anttila and Winsvold, {Bendik S.} and Priit Palta and Tonu Esko and Pers, {Tune H.} and Farh, {Kai How} and Ester Cuenca-Leon and Mikko Muona and Furlotte, {Nicholas A.} and Tobias Kurth and Andres Ingason and George McMahon and Lannie Ligthart and Terwindt, {Gisela M.} and Mikko Kallela and Freilinger, {Tobias M.} and Caroline Ran and Gordon, {Scott G.} and Stam, {Anine H.} and Stacy Steinberg and Guntram Borck and Markku Koiranen and Lydia Quaye and Adams, {Hieab H.H.} and Terho Lehtim{\"a}ki and Sarin, {Antti Pekka} and Juho Wedenoja and Hinds, {David A.} and Buring, {Julie E.} and Markus Sch{\"u}rks and Ridker, {Paul M.} and Hrafnsdottir, {Maria Gudlaug} and Hreinn Stefansson and Ring, {Susan M.} and Hottenga, {Jouke Jan} and Penninx, {Brenda W.J.H.} and Markus F{\"a}rkkil{\"a} and Ville Artto and Mari Kaunisto and Salli Veps{\"a}l{\"a}inen and Rainer Malik and Christensen, {Anne Francke} and Hansen, {Thomas Folkmann} and Thomas Werge and Jes Olesen and {The International Headache Genetics Consortium} and {the 23andMe Research Team}",
year = "2020",
doi = "10.1038/s41467-020-17002-0",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

AU - Guo, Yanjun

AU - Rist, Pamela M.

AU - Daghlas, Iyas

AU - Giulianini, Franco

AU - Gormley, Padhraig

AU - Anttila, Verneri

AU - Winsvold, Bendik S.

AU - Palta, Priit

AU - Esko, Tonu

AU - Pers, Tune H.

AU - Farh, Kai How

AU - Cuenca-Leon, Ester

AU - Muona, Mikko

AU - Furlotte, Nicholas A.

AU - Kurth, Tobias

AU - Ingason, Andres

AU - McMahon, George

AU - Ligthart, Lannie

AU - Terwindt, Gisela M.

AU - Kallela, Mikko

AU - Freilinger, Tobias M.

AU - Ran, Caroline

AU - Gordon, Scott G.

AU - Stam, Anine H.

AU - Steinberg, Stacy

AU - Borck, Guntram

AU - Koiranen, Markku

AU - Quaye, Lydia

AU - Adams, Hieab H.H.

AU - Lehtimäki, Terho

AU - Sarin, Antti Pekka

AU - Wedenoja, Juho

AU - Hinds, David A.

AU - Buring, Julie E.

AU - Schürks, Markus

AU - Ridker, Paul M.

AU - Hrafnsdottir, Maria Gudlaug

AU - Stefansson, Hreinn

AU - Ring, Susan M.

AU - Hottenga, Jouke Jan

AU - Penninx, Brenda W.J.H.

AU - Färkkilä, Markus

AU - Artto, Ville

AU - Kaunisto, Mari

AU - Vepsäläinen, Salli

AU - Malik, Rainer

AU - Christensen, Anne Francke

AU - Hansen, Thomas Folkmann

AU - Werge, Thomas

AU - Olesen, Jes

AU - The International Headache Genetics Consortium

AU - the 23andMe Research Team

PY - 2020

Y1 - 2020

N2 - Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15–1.25]/10 mmHg; P = 5.57 × 10−25) on migraine than SBP (1.05 [1.03–1.07]/10 mmHg; P = 2.60 × 10−07) and a corresponding opposite effect for PP (0.92 [0.88–0.95]/10 mmHg; P = 3.65 × 10−07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.

AB - Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15–1.25]/10 mmHg; P = 5.57 × 10−25) on migraine than SBP (1.05 [1.03–1.07]/10 mmHg; P = 2.60 × 10−07) and a corresponding opposite effect for PP (0.92 [0.88–0.95]/10 mmHg; P = 3.65 × 10−07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.

U2 - 10.1038/s41467-020-17002-0

DO - 10.1038/s41467-020-17002-0

M3 - Journal article

C2 - 32632093

AN - SCOPUS:85087503588

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3368

ER -

ID: 251692593