Genetic mapping of etiologic brain cell types for obesity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genetic mapping of etiologic brain cell types for obesity. / Timshel, Pascal N.; Thompson, Jonatan J.; Pers, Tune H.

In: eLife, Vol. 9, 55851, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Timshel, PN, Thompson, JJ & Pers, TH 2020, 'Genetic mapping of etiologic brain cell types for obesity', eLife, vol. 9, 55851. https://doi.org/10.7554/eLife.55851

APA

Timshel, P. N., Thompson, J. J., & Pers, T. H. (2020). Genetic mapping of etiologic brain cell types for obesity. eLife, 9, [55851]. https://doi.org/10.7554/eLife.55851

Vancouver

Timshel PN, Thompson JJ, Pers TH. Genetic mapping of etiologic brain cell types for obesity. eLife. 2020;9. 55851. https://doi.org/10.7554/eLife.55851

Author

Timshel, Pascal N. ; Thompson, Jonatan J. ; Pers, Tune H. / Genetic mapping of etiologic brain cell types for obesity. In: eLife. 2020 ; Vol. 9.

Bibtex

@article{f19356210b2f4a3e807eff6dd98404d6,
title = "Genetic mapping of etiologic brain cell types for obesity",
abstract = "The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p",
keywords = "GENOME-WIDE ASSOCIATION, BODY-MASS INDEX, PARTITIONING HERITABILITY, ENERGY-BALANCE, FOOD-INTAKE, EXPRESSION, VARIANTS, CIRCUIT, MOUSE, COMMON",
author = "Timshel, {Pascal N.} and Thompson, {Jonatan J.} and Pers, {Tune H.}",
year = "2020",
doi = "10.7554/eLife.55851",
language = "English",
volume = "9",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Genetic mapping of etiologic brain cell types for obesity

AU - Timshel, Pascal N.

AU - Thompson, Jonatan J.

AU - Pers, Tune H.

PY - 2020

Y1 - 2020

N2 - The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p

AB - The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p

KW - GENOME-WIDE ASSOCIATION

KW - BODY-MASS INDEX

KW - PARTITIONING HERITABILITY

KW - ENERGY-BALANCE

KW - FOOD-INTAKE

KW - EXPRESSION

KW - VARIANTS

KW - CIRCUIT

KW - MOUSE

KW - COMMON

U2 - 10.7554/eLife.55851

DO - 10.7554/eLife.55851

M3 - Journal article

C2 - 32955435

VL - 9

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 55851

ER -

ID: 249944656