Hindbrain circuits in the control of eating behaviour and energy balance

Research output: Contribution to journalReviewpeer-review

  • Wenwen Cheng
  • Desiree Gordian
  • Mette Q. Ludwig
  • Pers, Tune H
  • Randy J. Seeley
  • Martin G. Myers

Body weight and adiposity represent biologically controlled parameters that are influenced by a combination of genetic, developmental and environmental variables. Although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now recognized that neuronal circuits in the hindbrain not only serve to produce nausea and to terminate feeding in response to food consumption or during pathological states, but also contribute to the long-term control of body weight. Additionally, recent work has identified hindbrain neurons that are capable of suppressing food intake without producing aversive responses like those associated with nausea. Here we review recent advances in our understanding of the hindbrain neurons that control feeding, particularly those located in the area postrema and the nucleus tractus solitarius. We frame this information in the context of new atlases of hindbrain neuronal populations and develop a model of the hindbrain circuits that control food intake and energy balance, suggesting important areas for additional research.

Original languageEnglish
JournalNature Metabolism
Issue number7
Pages (from-to)826-835
Number of pages10
Publication statusPublished - 2022

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