Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex

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Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex. / Ludwig, Mette Q.; Todorov, Petar V.; Egerod, Kristoffer L.; Olson, David P.; Pers, Tune H.

In: Diabetes, Vol. 70, No. 9, 2021, p. 1945-1955.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ludwig, MQ, Todorov, PV, Egerod, KL, Olson, DP & Pers, TH 2021, 'Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex', Diabetes, vol. 70, no. 9, pp. 1945-1955. https://doi.org/10.2337/dbi21-0003

APA

Ludwig, M. Q., Todorov, P. V., Egerod, K. L., Olson, D. P., & Pers, T. H. (2021). Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex. Diabetes, 70(9), 1945-1955. https://doi.org/10.2337/dbi21-0003

Vancouver

Ludwig MQ, Todorov PV, Egerod KL, Olson DP, Pers TH. Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex. Diabetes. 2021;70(9):1945-1955. https://doi.org/10.2337/dbi21-0003

Author

Ludwig, Mette Q. ; Todorov, Petar V. ; Egerod, Kristoffer L. ; Olson, David P. ; Pers, Tune H. / Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex. In: Diabetes. 2021 ; Vol. 70, No. 9. pp. 1945-1955.

Bibtex

@article{8bdc69bd57954d489fa519cf44495ee6,
title = "Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex",
abstract = "The dorsal vagal complex (DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, plays a critical role in modulating satiety. The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to modulate feeding, and receptors for both are expressed in the DVC. Given the impressive clinical responses to pharmacologic manipulation of incretin signaling, understanding the central mechanisms by which incretins alter metabolism and energy balance is of critical importance. Here, we review recent single-cell approaches used to detect molecular signatures of GLP-1 and GIP receptor-expressing cells in the DVC. In addition, we discuss how current advancements in single-cell transcriptomics, epigenetics, spatial transcriptomics, and circuit mapping techniques have the potential to further characterize incretin receptor circuits in the hindbrain.",
keywords = "NUCLEUS-TRACTUS-SOLITARIUS, PEPTIDE-1 RECEPTOR, AREA POSTREMA, GLUCAGON, RNA, HINDBRAIN, NEURONS, TRANSCRIPTION, CHROMATIN, PROTEINS",
author = "Ludwig, {Mette Q.} and Todorov, {Petar V.} and Egerod, {Kristoffer L.} and Olson, {David P.} and Pers, {Tune H.}",
year = "2021",
doi = "10.2337/dbi21-0003",
language = "English",
volume = "70",
pages = "1945--1955",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "9",

}

RIS

TY - JOUR

T1 - Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex

AU - Ludwig, Mette Q.

AU - Todorov, Petar V.

AU - Egerod, Kristoffer L.

AU - Olson, David P.

AU - Pers, Tune H.

PY - 2021

Y1 - 2021

N2 - The dorsal vagal complex (DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, plays a critical role in modulating satiety. The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to modulate feeding, and receptors for both are expressed in the DVC. Given the impressive clinical responses to pharmacologic manipulation of incretin signaling, understanding the central mechanisms by which incretins alter metabolism and energy balance is of critical importance. Here, we review recent single-cell approaches used to detect molecular signatures of GLP-1 and GIP receptor-expressing cells in the DVC. In addition, we discuss how current advancements in single-cell transcriptomics, epigenetics, spatial transcriptomics, and circuit mapping techniques have the potential to further characterize incretin receptor circuits in the hindbrain.

AB - The dorsal vagal complex (DVC) in the hindbrain, composed of the area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, plays a critical role in modulating satiety. The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) act directly in the brain to modulate feeding, and receptors for both are expressed in the DVC. Given the impressive clinical responses to pharmacologic manipulation of incretin signaling, understanding the central mechanisms by which incretins alter metabolism and energy balance is of critical importance. Here, we review recent single-cell approaches used to detect molecular signatures of GLP-1 and GIP receptor-expressing cells in the DVC. In addition, we discuss how current advancements in single-cell transcriptomics, epigenetics, spatial transcriptomics, and circuit mapping techniques have the potential to further characterize incretin receptor circuits in the hindbrain.

KW - NUCLEUS-TRACTUS-SOLITARIUS

KW - PEPTIDE-1 RECEPTOR

KW - AREA POSTREMA

KW - GLUCAGON

KW - RNA

KW - HINDBRAIN

KW - NEURONS

KW - TRANSCRIPTION

KW - CHROMATIN

KW - PROTEINS

U2 - 10.2337/dbi21-0003

DO - 10.2337/dbi21-0003

M3 - Journal article

C2 - 34176785

VL - 70

SP - 1945

EP - 1955

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 9

ER -

ID: 282039541