Schéele Group

  1. 2024
  2. Published
  3. 2023
  4. Published

    De-novo reconstruction and identification of transcriptional gene regulatory network modules differentiating single-cell clusters

    Oubounyt, M., Elkjaer, M. L., Laske, T., Grønning, Alexander GB, Moeller, M. J. & Baumbach, J., 2023, In: NAR Genomics and Bioinformatics. 5, 1, 17 p., lqad018.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

    Block, A. M., Namugenyi, S. B., Palani, Nagendra Prasad, Brokaw, A. M., Zhang, L., Beckman, K. B. & Tischler, A. D., 2023, In: mSystems. 8, 1, 19 p., e0069922.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots

    Palani, Nagendra Prasad, Horvath, C., Timshel, P. N., Folkertsma, P., Grønning, Alexander GB, Henriksen, T. I., Peijs, Lone, Jensen, V. H., Sun, W., Jespersen, N. Z., Wolfrum, C., Pers, Tune H, Nielsen, S. & Schéele, Camilla Charlotte Nielsen, 2023, In: Nature Metabolism. 5, 6, p. 996-1013 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. 2022
  8. Published

    Can we target obesity using a single-cell atlas of adipose tissue?

    Schéele, Camilla Charlotte Nielsen & Nielsen, S., 2022, In: Med. 3, 5, p. 276-278 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  9. Published

    Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity

    Hayashi, Y., Shimizu, I., Yoshida, Y., Ikegami, R., Suda, M., Katsuumi, G., Fujiki, S., Ozaki, K., Abe, M., Sakimura, K., Okuda, S., Hayano, T., Nakamura, K., Walsh, K., Jespersen, N. Z., Nielsen, S., Schéele, Camilla Charlotte Nielsen & Minamino, T., 2022, In: iScience. 25, 7, 23 p., 104547.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Himalayan bacterial endophytes enhance microalgal cell numbers and chlorophyll content in synthetic co-culture

    Sonowal, S., Palani, Nagendra Prasad, Ahmed, R., Debbarma, J., Chikkaputtaiah, C., Basar, E. & Velmurugan, N., 2022, In: Journal of Applied Phycology. 34, 5, p. 2383-2400

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

    Mathur, N., Severinsen, M. C. K., Jensen, M. E., Naver, L., Schrölkamp, Maren, Laye, M. J., Watt, M. J., Nielsen, S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund & Schéele, Camilla Charlotte Nielsen, 2022, In: Frontiers in Cell and Developmental Biology. 10, 12 p., 983899.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Isolation and Characterization of Human Brown Adipocytes

    Schéele, Camilla Charlotte Nielsen, Henriksen, T. I. & Nielsen, S., 2022, In: Methods in Molecular Biology. 2448, p. 217-234 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    PRDM16 stability and metabolically healthy adipose tissue

    Horvath, C. & Schéele, Camilla Charlotte Nielsen, 2022, In: Nature Metabolism. 4, p. 1095-1096

    Research output: Contribution to journalComment/debate

  14. Published

    The human batokine EPDR1 regulates β-cell metabolism and function

    Cataldo Bascunan, Luis Rodrigo, Gao, Q., Argemi Muntadas, Lidia, Hodek, O., Cowan, E., Hladkou, S., Gheibi, S., Spegel, P., Prasad, R. B., Eliasson, L., Schéele, Camilla Charlotte Nielsen, Fex, M., Mulder, H. & Moritz, Thomas, 2022, In: Molecular Metabolism. 66, 14 p., 101629.

    Research output: Contribution to journalJournal articlepeer-review

  15. 2021
  16. Published

    Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

    Soberg, S., Löfgren, J., Philipsen, F. E., Jensen, M., Hansen, Adam Espe, Ahrens, E., Nystrup, K. B., Nielsen, R. D., Solling, C., Wedell-Neergaard, A., Berntsen, M., Loft, A., Kjær, Andreas, Gerhart-Hines, Zach, Johannesen, H. H., Pedersen, Bente Klarlund, Karstoft, Kristian & Schéele, Camilla Charlotte Nielsen, 2021, In: Cell Reports Medicine. 2, 10, 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?

    Henningsen, J. B. & Schéele, Camilla Charlotte Nielsen, 2021, In: Annual Review of Physiology. 83, p. 279-301 23 p.

    Research output: Contribution to journalReviewpeer-review

  18. Published

    Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

    Löffler, M. C., Betz, M. J., Blondin, D. P., Augustin, R., Sharma, A. K., Tseng, Y. H., Schéele, Camilla Charlotte Nielsen, Zimdahl, H., Mark, M., Hennige, A. M., Wolfrum, C., Langhans, W., Hamilton, B. S. & Neubauer, H., 2021, In: Molecular Metabolism. 51, 15 p., 101237.

    Research output: Contribution to journalReviewpeer-review

  19. Published
  20. Published

    Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

    Henningsen, J. B., Soylu-Kucharz, R., Bjorkqvist, M. & Petersen, Å., 2021, In: Heliyon. 7, 8, 9 p., 07808.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Enabling single-cell trajectory network enrichment

    Grønning, Alexander GB, Oubounyt, M., Kanev, K., Lund, J., Kacprowski, T., Zehn, D., Röttger, R. & Baumbach, J., 2021, In: Nature Computational Science. 1, 2, p. 153-163

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

    Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Darkwah, A., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y. H., Heeren, J. & 1 others, Scheja, L., 2021, In: Cell Reports. 34, 2, 19 p., 108624.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Functional diversity of human adipose tissue revealed by spatial mapping

    Schéele, Camilla Charlotte Nielsen & Wolfrum, C., 2021, In: Nature Reviews Endocrinology. 17, p. 713-714 2 p.

    Research output: Contribution to journalEditorial

  24. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    MultiPep: a hierarchical deep learning approach for multi-label classification of peptide bioactivities

    Grønning, Alexander GB, Kacprowski, T. & Schéele, Camilla Charlotte Nielsen, 2021, In: Biology Methods and Protocols. 6, 1, 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Perspectives on the role of brown adipose tissue in human body temperature and metabolism

    Schéele, Camilla Charlotte Nielsen, 2021, In: Cell Reports Medicine. 2, 10, 3 p., 100427.

    Research output: Contribution to journalEditorial

  27. Published

    Transient postprandial increase in intact circulating fibroblast growth factor-21 levels after Roux-en-Y gastric bypass: A randomized controlled clinical trial

    Nielsen, M. S., Søberg, S., Schmidt, J. B., Chenchar, A., Sjödin, Anders Mikael & Gillum, M. P., 2021, In: PeerJ. 9, 14 p., e11174.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

    Davegårdh, C., Säll, J., Benrick, A., Broholm, C., Volkov, P., Perfilyev, A., Henriksen, T. I., Wu, Y., Hjort, L., Brøns, C., Hansson, O., Pedersen, M., Würthner, J. U., Pfeffer, K., Nilsson, E., Vaag, Allan, Stener-Victorin, E., Pircs, K., Schéele, Camilla Charlotte Nielsen & Ling, C., 2021, In: Nature Communications. 12, 1, 20 p., 2431.

    Research output: Contribution to journalJournal articlepeer-review

  29. 2020
  30. Published

    Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity

    Gnad, T., Navarro, G., Lahesmaa, M., Reverte-Salisa, L., Copperi, F., Cordomi, A., Naumann, J., Hochhaeuser, A., Haufs-Brusberg, S., Wenzel, D., Suhr, F., Jespersen, N. Z., Scheele, C., Tsvilovskyy, V., Brinkmann, C., Rittweger, J., Dani, C., Kranz, M., Deuther-Conrad, W., Eltzschig, H. K. & 11 others, Niemi, T., Taittonen, M., Brust, P., Nuutila, P., Pardo, L., Fleischmann, B. K., Blueher, M., Franco, R., Bloch, W., Virtanen, K. A. & Pfeifer, A., 2020, In: Cell Metabolism. 32, 1, p. 56-70.e7 22 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism

    Schéele, Camilla Charlotte Nielsen & Wolfrum, C., 2020, In: Endocrine Reviews. 41, 1, p. 53-65

    Research output: Contribution to journalReviewpeer-review

  32. Published

    Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat

    Plucinska, Kaja, Jespersen, N. Z., Brown, E. L., Petersen, P. S., Rupar, K., Nielsen, S., Schéele, Camilla Charlotte Nielsen & Emanuelli, Brice, 2020, In: Frontiers in Endocrinology. 11, 7 p., 579785.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Epigenome- and transcriptome-wide changes in muscle stem cells from low birth weight men

    Broholm, C., Ribel-Madsen, R., Hjort, L., Olsson, A. H., Ahlers, J. M. D., Hansen, N. S., Schrölkamp, Maren, Gillberg, Linn, Perfilyev, A., Volkov, P., Ling, C., Jørgensen, S. W., Mortensen, B., Hingst, J. R., Wojtaszewski, Jørgen F P, Schéele, Camilla Charlotte Nielsen, Brøns, C., Pedersen, Bente Klarlund & Vaag, Allan, 2020, In: Endocrine Research. 45, 1, p. 58-71 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Exercise and browning of white adipose tissue - a translational perspective

    Severinsen, M. C. K., Schéele, Camilla Charlotte Nielsen & Pedersen, Bente Klarlund, 2020, In: Current Opinion in Pharmacology. 52, p. 18-24 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Human Brown Adipocyte Thermogenesis Is Driven by beta 2-AR Stimulation

    Blondin, D. P., Nielsen, S., Kuipers, E. N., Severinsen, M. C., Jensen, V. H., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., Phoenix, S., Frisch, F., Guerin, B., Turcotte, E. E., Haman, F., Richard, D., Picard, F., Rensen, P. C. N., Schéele, Camilla Charlotte Nielsen & Carpentier, A. C., 2020, In: Cell Metabolism. 32, 2, p. 287-300.e7 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473

    Khanh-Van Tran, Brown, E. L., DeSouza, T., Jespersen, N. Z., Nandrup-Bus, C., Yang, Q., Yang, Z., Desai, A., Min, S. Y., Rojas-Rodriguez, R., Lundh, M., Feizi, A., Willenbrock, H., Larsen, T. J., Severinsen, M. C. K., Malka, K., Mozzicato, A. M., Deshmukh, A. S., Emanuelli, B., Pedersen, B. K. & 4 others, Fitzgibbons, T., Schéele, Camilla Charlotte Nielsen, Corvera, S. & Nielsen, S., 2020, In: Nature Metabolism. 2, p. 397-412

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Muscle-Organ Crosstalk: The Emerging Roles of Myokines

    Severinsen, M. C. K. & Pedersen, Bente Klarlund, 2020, In: Endocrine Reviews. 41, 4, p. 594-609

    Research output: Contribution to journalReviewpeer-review

  38. Published

    Next Generation Diabetes Scientists Shape Global Research Culture: A reflective proposal from postdoctoral researchers in diabetes research

    Gonzalez-Franquesa, A., Carrasquilla Lopez, G. D., Mamidi, A., Ghiasi, S. M., Juel, H. B., Falk, S., Isidor, M. S., Gillberg, L. M. E., Huang, L. O., Quist, J. S., Knudsen, J. R., Quaranta, R., Tozzi, M., Mikkelsen, R. B., Dall, M., Drag, M. H., Small, L. B., Altıntaş, A., Osborne, B., Modvig, I. M. & 11 others, Husted, Anna Sofie, Brown, E. L., Bak, Emilie Glad, Bastos Peluso, A. A., Finger, Fabian Michael, Grunddal, Kaare Villum, Rupar, K., Henningsen, J. B., Pedersen, M. H., Plucinska, Kaja & Attendees of the Danish Diabetes Academy Winter School 2019, A. O. T. D. D. A. W. S. 2., 2020, In: Acta Physiologica. 229, 2, 5 p., e13455.

    Research output: Contribution to journalComment/debate

  39. 2019
  40. Published

    An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Ziegler, A. K., Damgaard, A., Mackey, Abigail, Schjerling, Peter, Magnusson, Stig Peter, Olesen, A. T., Kjær, Michael & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p., 12069.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

    Min, S. Y., Desai, A., Yang, Z., Sharma, A., DeSouza, T., Genga, R. M. J., Kucukural, A., Lifshitz, L. M., Nielsen, S., Schéele, Camilla Charlotte Nielsen, Maehr, R., Garber, M. & Corvera, S., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17970-17979

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes

    Henriksen, T. I., Wigge, L. V., Nielsen, J., Pedersen, Bente Klarlund, Sandri, M. & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

    Jespersen, N. Z., Feizi, A., Andersen, E. S., Heywood, S., Hattel, H. B., Daugaard, S., Peijs, Lone, Bagi, P., Feldt-Rasmussen, Bo, Schultz, H. S., Hansen, N. S., Krogh-Madsen, Rikke, Pedersen, Bente Klarlund, Petrovic, N., Nielsen, S. & Schéele, Camilla Charlotte Nielsen, 2019, In: Molecular Metabolism. 24, p. 30-43 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

    de Jong, J. M. A., Sun, W., Pires, N. D., Frontini, A., Balaz, M., Jespersen, N. Z., Feizi, A., Petrovic, K., Fischer, A. W., Bokhari, M. H., Niemi, T., Nuutila, P., Cinti, S., Nielsen, S., Schéele, Camilla Charlotte Nielsen, Virtanen, K., Cannon, B., Nedergaard, J., Wolfrum, C. & Petrovic, N., 2019, In: Nature Metabolism. 1, p. 830-843

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

    Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Roettger, R., Baumbach, J., Schéele, Camilla Charlotte Nielsen, Kassem, M. & Mandrup, S., 2019, In: Nature Genetics. 51, 4, p. 716-727

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, Nielsen, S., Drucker, D. J., Mann, Matthias & Schéele, Camilla Charlotte Nielsen, 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

    Davegardh, C., Wedin, E. H., Broholm, C., Henriksen, T. I., Pedersen, M., Pedersen, Bente Klarlund, Schéele, Camilla Charlotte Nielsen & Ling, C., 2019, In: Stem Cell Research & Therapy. 10

    Research output: Contribution to journalJournal articlepeer-review

  48. 2018
  49. Published

    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

    Sanchez-Gurmaches, J., Tang, Y., Jespersen, N. Z., Wallace, M., Martinez Calejman, C., Gujja, S., Li, H., Edwards, Y. J. K., Wolfrum, C., Metallo, C. M., Nielsen, S., Schéele, Camilla Charlotte Nielsen & Guertin, D. A., 9 Jan 2018, In: Cell Metabolism. 27, 1, p. 195-209.e6

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

    Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 others, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, Allan René, Pedersen, Oluf Borbye, Kiebish, M. A., Qvortrup, Klaus, Han, X., Pedersen, Bente Klarlund, Jastroch, M., Mandrup, S., Kjær, Andreas, Gygi, S. P., Hansen, Torben, Gillum, M. P., Grarup, Niels, Emanuelli, Brice, Nielsen, S., Schéele, Camilla Charlotte Nielsen, Tseng, Y., Færgeman, N. J. & Gerhart-Hines, Zach, 2018, In: Cell Metabolism. 28, 1, p. 159-174.e11

    Research output: Contribution to journalJournal articlepeer-review

  51. 2017
  52. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

    Søberg, S., Sandholt, C. H., Z. Jespersen, N., Toft, U., L. Madsen, A., Holstein-Rønsbo, Stephanie, Grevengoed, Trisha Jean, Christensen, Karl Bang, Bredie, Wender, Potthoff, M. J., P. J. Solomon, T., Schéele, Camilla Charlotte Nielsen, Linneberg, Allan René, Jørgensen, T., Pedersen, Oluf Borbye, Hansen, Torben, Gillum, M. P. & Grarup, Niels, 2017, In: Cell Metabolism. 25, 5, p. 1045-1053 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. 2016
  55. Published

    The role of kisspeptin and RFRP in the circadian control of female reproduction

    Beymer, M., Henningsen, J., Bahougne, T. & Simonneaux, V., 15 Dec 2016, In: Molecular and Cellular Endocrinology. 438, p. 89-99 11 p.

    Research output: Contribution to journalReviewpeer-review

  56. Published

    RFRP Neurons - The Doorway to Understanding Seasonal Reproduction in Mammals

    Henningsen, J. B., Gauer, F. & Simonneaux, V., 2016, In: Frontiers in Endocrinology. 7, p. 36

    Research output: Contribution to journalReviewpeer-review