Protective succinate-SUCNR1 metabolic stress signaling gone bad

Research output: Contribution to journalJournal articlepeer-review

The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

Original languageEnglish
JournalCell Metabolism
Volume33
Issue number7
Pages (from-to)1276-1278
Number of pages3
ISSN1550-4131
DOIs
Publication statusPublished - 2021

    Research areas

  • EXTRACELLULAR SUCCINATE, MACROPHAGES

ID: 275484275