Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

Research output: Contribution to journalJournal articlepeer-review

Standard

Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial. / Ferraz-Bannitz, Rafael; Beraldo, Rebeca A.; Peluso, Augusto; Dall, Morten; Babaei, Parizad; Foglietti, Rayana Cardoso; Martins, Larissa Marfori; Gomes, Patricia Moreira; Marchini, Julio Sergio; Miguel Suen, Vivian Marques; Conti de Freitas, Luiz C.; Navegantes, Luiz Carlos; Pretti, Marco Antônio M.; Boroni, Mariana; Treebak, Jonas T.; Mori, Marcelo A.; Foss, Milton Cesar; Foss-Freitas, Maria Cristina.

In: Nutrients, Vol. 14, No. 13, 2670, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ferraz-Bannitz, R, Beraldo, RA, Peluso, A, Dall, M, Babaei, P, Foglietti, RC, Martins, LM, Gomes, PM, Marchini, JS, Miguel Suen, VM, Conti de Freitas, LC, Navegantes, LC, Pretti, MAM, Boroni, M, Treebak, JT, Mori, MA, Foss, MC & Foss-Freitas, MC 2022, 'Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial', Nutrients, vol. 14, no. 13, 2670. https://doi.org/10.3390/nu14132670

APA

Ferraz-Bannitz, R., Beraldo, R. A., Peluso, A., Dall, M., Babaei, P., Foglietti, R. C., Martins, L. M., Gomes, P. M., Marchini, J. S., Miguel Suen, V. M., Conti de Freitas, L. C., Navegantes, L. C., Pretti, M. A. M., Boroni, M., Treebak, J. T., Mori, M. A., Foss, M. C., & Foss-Freitas, M. C. (2022). Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial. Nutrients, 14(13), [2670]. https://doi.org/10.3390/nu14132670

Vancouver

Ferraz-Bannitz R, Beraldo RA, Peluso A, Dall M, Babaei P, Foglietti RC et al. Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial. Nutrients. 2022;14(13). 2670. https://doi.org/10.3390/nu14132670

Author

Ferraz-Bannitz, Rafael ; Beraldo, Rebeca A. ; Peluso, Augusto ; Dall, Morten ; Babaei, Parizad ; Foglietti, Rayana Cardoso ; Martins, Larissa Marfori ; Gomes, Patricia Moreira ; Marchini, Julio Sergio ; Miguel Suen, Vivian Marques ; Conti de Freitas, Luiz C. ; Navegantes, Luiz Carlos ; Pretti, Marco Antônio M. ; Boroni, Mariana ; Treebak, Jonas T. ; Mori, Marcelo A. ; Foss, Milton Cesar ; Foss-Freitas, Maria Cristina. / Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial. In: Nutrients. 2022 ; Vol. 14, No. 13.

Bibtex

@article{0223ccc5d6114f488585af699a59259c,
title = "Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial",
abstract = "Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive whether the benefits of DR in humans are mediated by calorie or nutrient restriction. This study was conducted to determine whether isocaloric dietary protein restriction is sufficient to confer the beneficial effects of dietary restriction in patients with metabolic syndrome. We performed a prospective, randomized controlled dietary intervention under constant nutritional and medical supervision. Twenty-one individuals diagnosed with metabolic syndrome were randomly assigned for caloric restriction (CR; n = 11, diet of 5941 686 KJ per day) or isocaloric dietary protein restriction (PR; n = 10, diet of 8409 2360 KJ per day) and followed for 27 days. Like CR, PR promoted weight loss due to a reduction in adiposity, which was associated with reductions in blood glucose, lipid levels, and blood pressure. More strikingly, both CR and PR improved insulin sensitivity by 62.3% and 93.2%, respectively, after treatment. Fecal microbiome diversity was not affected by the interventions. Adipose tissue bulk RNA-Seq data revealed minor changes elicited by the interventions. After PR, terms related to leukocyte proliferation were enriched among the upregulated genes. Protein restriction is sufficient to confer almost the same clinical outcomes as calorie restriction without the need for a reduction in calorie intake. The isocaloric characteristic of the PR intervention makes this approach a more attractive and less drastic dietary strategy in clinical settings and has more significant potential to be used as adjuvant therapy for people with metabolic syndrome.",
keywords = "caloric restriction, cardiovascular disease, insulin resistance, metabolic syndrome, protein restriction, type 2 diabetes",
author = "Rafael Ferraz-Bannitz and Beraldo, {Rebeca A.} and Augusto Peluso and Morten Dall and Parizad Babaei and Foglietti, {Rayana Cardoso} and Martins, {Larissa Marfori} and Gomes, {Patricia Moreira} and Marchini, {Julio Sergio} and {Miguel Suen}, {Vivian Marques} and {Conti de Freitas}, {Luiz C.} and Navegantes, {Luiz Carlos} and Pretti, {Marco Ant{\^o}nio M.} and Mariana Boroni and Treebak, {Jonas T.} and Mori, {Marcelo A.} and Foss, {Milton Cesar} and Foss-Freitas, {Maria Cristina}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
doi = "10.3390/nu14132670",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "13",

}

RIS

TY - JOUR

T1 - Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

AU - Ferraz-Bannitz, Rafael

AU - Beraldo, Rebeca A.

AU - Peluso, Augusto

AU - Dall, Morten

AU - Babaei, Parizad

AU - Foglietti, Rayana Cardoso

AU - Martins, Larissa Marfori

AU - Gomes, Patricia Moreira

AU - Marchini, Julio Sergio

AU - Miguel Suen, Vivian Marques

AU - Conti de Freitas, Luiz C.

AU - Navegantes, Luiz Carlos

AU - Pretti, Marco Antônio M.

AU - Boroni, Mariana

AU - Treebak, Jonas T.

AU - Mori, Marcelo A.

AU - Foss, Milton Cesar

AU - Foss-Freitas, Maria Cristina

N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022

Y1 - 2022

N2 - Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive whether the benefits of DR in humans are mediated by calorie or nutrient restriction. This study was conducted to determine whether isocaloric dietary protein restriction is sufficient to confer the beneficial effects of dietary restriction in patients with metabolic syndrome. We performed a prospective, randomized controlled dietary intervention under constant nutritional and medical supervision. Twenty-one individuals diagnosed with metabolic syndrome were randomly assigned for caloric restriction (CR; n = 11, diet of 5941 686 KJ per day) or isocaloric dietary protein restriction (PR; n = 10, diet of 8409 2360 KJ per day) and followed for 27 days. Like CR, PR promoted weight loss due to a reduction in adiposity, which was associated with reductions in blood glucose, lipid levels, and blood pressure. More strikingly, both CR and PR improved insulin sensitivity by 62.3% and 93.2%, respectively, after treatment. Fecal microbiome diversity was not affected by the interventions. Adipose tissue bulk RNA-Seq data revealed minor changes elicited by the interventions. After PR, terms related to leukocyte proliferation were enriched among the upregulated genes. Protein restriction is sufficient to confer almost the same clinical outcomes as calorie restriction without the need for a reduction in calorie intake. The isocaloric characteristic of the PR intervention makes this approach a more attractive and less drastic dietary strategy in clinical settings and has more significant potential to be used as adjuvant therapy for people with metabolic syndrome.

AB - Dietary restriction (DR) reduces adiposity and improves metabolism in patients with one or more symptoms of metabolic syndrome. Nonetheless, it remains elusive whether the benefits of DR in humans are mediated by calorie or nutrient restriction. This study was conducted to determine whether isocaloric dietary protein restriction is sufficient to confer the beneficial effects of dietary restriction in patients with metabolic syndrome. We performed a prospective, randomized controlled dietary intervention under constant nutritional and medical supervision. Twenty-one individuals diagnosed with metabolic syndrome were randomly assigned for caloric restriction (CR; n = 11, diet of 5941 686 KJ per day) or isocaloric dietary protein restriction (PR; n = 10, diet of 8409 2360 KJ per day) and followed for 27 days. Like CR, PR promoted weight loss due to a reduction in adiposity, which was associated with reductions in blood glucose, lipid levels, and blood pressure. More strikingly, both CR and PR improved insulin sensitivity by 62.3% and 93.2%, respectively, after treatment. Fecal microbiome diversity was not affected by the interventions. Adipose tissue bulk RNA-Seq data revealed minor changes elicited by the interventions. After PR, terms related to leukocyte proliferation were enriched among the upregulated genes. Protein restriction is sufficient to confer almost the same clinical outcomes as calorie restriction without the need for a reduction in calorie intake. The isocaloric characteristic of the PR intervention makes this approach a more attractive and less drastic dietary strategy in clinical settings and has more significant potential to be used as adjuvant therapy for people with metabolic syndrome.

KW - caloric restriction

KW - cardiovascular disease

KW - insulin resistance

KW - metabolic syndrome

KW - protein restriction

KW - type 2 diabetes

U2 - 10.3390/nu14132670

DO - 10.3390/nu14132670

M3 - Journal article

C2 - 35807851

AN - SCOPUS:85133710781

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 13

M1 - 2670

ER -

ID: 314159865