Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

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Standard

Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. / Damgaard, Mads V.; Nielsen, Thomas S.; Basse, Astrid L.; Chubanava, Sabina; Trost, Kajetan; Moritz, Thomas; Dellinger, Ryan W.; Larsen, Steen; Treebak, Jonas T.

In: iScience, Vol. 25, No. 2, 103863, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Damgaard, MV, Nielsen, TS, Basse, AL, Chubanava, S, Trost, K, Moritz, T, Dellinger, RW, Larsen, S & Treebak, JT 2022, 'Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity', iScience, vol. 25, no. 2, 103863. https://doi.org/10.1016/j.isci.2022.103863

APA

Damgaard, M. V., Nielsen, T. S., Basse, A. L., Chubanava, S., Trost, K., Moritz, T., Dellinger, R. W., Larsen, S., & Treebak, J. T. (2022). Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. iScience, 25(2), [103863]. https://doi.org/10.1016/j.isci.2022.103863

Vancouver

Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T et al. Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. iScience. 2022;25(2). 103863. https://doi.org/10.1016/j.isci.2022.103863

Author

Damgaard, Mads V. ; Nielsen, Thomas S. ; Basse, Astrid L. ; Chubanava, Sabina ; Trost, Kajetan ; Moritz, Thomas ; Dellinger, Ryan W. ; Larsen, Steen ; Treebak, Jonas T. / Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. In: iScience. 2022 ; Vol. 25, No. 2.

Bibtex

@article{5635b9ed90d543d884610c3f7f6b6a39,
title = "Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity",
abstract = "In clinical trials, oral supplementation with nicotinamide riboside (NR) fails to increase muscle mitochondrial respiratory capacity and insulin sensitivity but also does not increase muscle NAD+ levels. This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. Accordingly, to improve bioavailability to skeletal muscle, we developed an experimental model for administering NR repeatedly through a jugular vein catheter. Mice on a Western diet were treated with various combinations of NR, pterostilbene (PT), and voluntary wheel running, but the metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.",
keywords = "Drugs, Molecular physiology, Transcriptomics",
author = "Damgaard, {Mads V.} and Nielsen, {Thomas S.} and Basse, {Astrid L.} and Sabina Chubanava and Kajetan Trost and Thomas Moritz and Dellinger, {Ryan W.} and Steen Larsen and Treebak, {Jonas T.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.isci.2022.103863",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

AU - Damgaard, Mads V.

AU - Nielsen, Thomas S.

AU - Basse, Astrid L.

AU - Chubanava, Sabina

AU - Trost, Kajetan

AU - Moritz, Thomas

AU - Dellinger, Ryan W.

AU - Larsen, Steen

AU - Treebak, Jonas T.

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - In clinical trials, oral supplementation with nicotinamide riboside (NR) fails to increase muscle mitochondrial respiratory capacity and insulin sensitivity but also does not increase muscle NAD+ levels. This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. Accordingly, to improve bioavailability to skeletal muscle, we developed an experimental model for administering NR repeatedly through a jugular vein catheter. Mice on a Western diet were treated with various combinations of NR, pterostilbene (PT), and voluntary wheel running, but the metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.

AB - In clinical trials, oral supplementation with nicotinamide riboside (NR) fails to increase muscle mitochondrial respiratory capacity and insulin sensitivity but also does not increase muscle NAD+ levels. This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. Accordingly, to improve bioavailability to skeletal muscle, we developed an experimental model for administering NR repeatedly through a jugular vein catheter. Mice on a Western diet were treated with various combinations of NR, pterostilbene (PT), and voluntary wheel running, but the metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.

KW - Drugs

KW - Molecular physiology

KW - Transcriptomics

U2 - 10.1016/j.isci.2022.103863

DO - 10.1016/j.isci.2022.103863

M3 - Journal article

C2 - 35198907

AN - SCOPUS:85124310023

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 2

M1 - 103863

ER -

ID: 298120319