Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
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Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes : from mice to men. / Hawley, John A.; Sassone-Corsi, Paolo; Zierath, Juleen R.
In: Diabetologia, Vol. 63, No. 11, 2020, p. 2253-2259.Research output: Contribution to journal › Review › peer-review
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TY - JOUR
T1 - Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes
T2 - from mice to men
AU - Hawley, John A.
AU - Sassone-Corsi, Paolo
AU - Zierath, Juleen R.
PY - 2020
Y1 - 2020
N2 - The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues unabated, with current recommendations for primary lifestyle changes (i.e. modification to dietary patterns) having a limited impact in reducing the incidence of these metabolic diseases. Part of the reason for the failure to alter nutritional practices is that current dietary recommendations may be unrealistic for the majority of adults. Indeed, round-the-clock access to energy-dense, nutrient-poor food makes long-term changes to dietary habits challenging. Hence, there is urgent need for innovations in the delivery of evidence-based diet interventions to rescue some of the deleterious effects on circadian biology induced by our modern-day lifestyle. With the growing appreciation that the duration over which food is consumed during a day has profound effects on numerous physiological and metabolic processes, we discuss dietary protocols that modify thetimingof food intake to deliberately alter the feeding-fasting cycle. Such chrono-nutrition functions to optimise metabolism by timing nutrient intake to the acrophases of metabolic rhythms to improve whole-body insulin sensitivity and glycaemic control, and thereby positively impact metabolic health.
AB - The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues unabated, with current recommendations for primary lifestyle changes (i.e. modification to dietary patterns) having a limited impact in reducing the incidence of these metabolic diseases. Part of the reason for the failure to alter nutritional practices is that current dietary recommendations may be unrealistic for the majority of adults. Indeed, round-the-clock access to energy-dense, nutrient-poor food makes long-term changes to dietary habits challenging. Hence, there is urgent need for innovations in the delivery of evidence-based diet interventions to rescue some of the deleterious effects on circadian biology induced by our modern-day lifestyle. With the growing appreciation that the duration over which food is consumed during a day has profound effects on numerous physiological and metabolic processes, we discuss dietary protocols that modify thetimingof food intake to deliberately alter the feeding-fasting cycle. Such chrono-nutrition functions to optimise metabolism by timing nutrient intake to the acrophases of metabolic rhythms to improve whole-body insulin sensitivity and glycaemic control, and thereby positively impact metabolic health.
KW - Chronic energy restriction
KW - Circadian disruption
KW - Circadian rhythm
KW - Diet
KW - Food
KW - Glycaemia
KW - Intermittent fasting
KW - Metabolic disease
KW - Obesity
KW - Review
KW - Time-restricted eating
KW - GLUCOSE-METABOLISM
KW - CIRCADIAN DISRUPTION
KW - PRACTICE GUIDELINE
KW - TIME
KW - DISEASE
KW - ADULTS
KW - FAT
KW - RECOMMENDATIONS
KW - INTERVENTION
KW - ASSOCIATION
U2 - 10.1007/s00125-020-05238-w
DO - 10.1007/s00125-020-05238-w
M3 - Review
C2 - 32761356
VL - 63
SP - 2253
EP - 2259
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 11
ER -
ID: 249860767