Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes
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Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes. / Andersen, Emil; Altıntaş, Ali; Andersson-Hall, Ulrika; Holmäng, Agneta; Barrès, Romain.
In: Epigenomics, Vol. 11, No. 8, 2019, p. 861-873.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes
AU - Andersen, Emil
AU - Altıntaş, Ali
AU - Andersson-Hall, Ulrika
AU - Holmäng, Agneta
AU - Barrès, Romain
PY - 2019
Y1 - 2019
N2 - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.
AB - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.
U2 - 10.2217/epi-2019-0055
DO - 10.2217/epi-2019-0055
M3 - Journal article
C2 - 30966798
VL - 11
SP - 861
EP - 873
JO - Epigenomics
JF - Epigenomics
SN - 1750-1911
IS - 8
ER -
ID: 216921552