Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Research output: Contribution to journalJournal articlepeer-review

Standard

Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes. / Andersen, Emil; Altıntaş, Ali; Andersson-Hall, Ulrika; Holmäng, Agneta; Barrès, Romain.

In: Epigenomics, Vol. 11, No. 8, 2019, p. 861-873.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Andersen, E, Altıntaş, A, Andersson-Hall, U, Holmäng, A & Barrès, R 2019, 'Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes', Epigenomics, vol. 11, no. 8, pp. 861-873. https://doi.org/10.2217/epi-2019-0055

APA

Andersen, E., Altıntaş, A., Andersson-Hall, U., Holmäng, A., & Barrès, R. (2019). Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes. Epigenomics, 11(8), 861-873. https://doi.org/10.2217/epi-2019-0055

Vancouver

Andersen E, Altıntaş A, Andersson-Hall U, Holmäng A, Barrès R. Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes. Epigenomics. 2019;11(8):861-873. https://doi.org/10.2217/epi-2019-0055

Author

Andersen, Emil ; Altıntaş, Ali ; Andersson-Hall, Ulrika ; Holmäng, Agneta ; Barrès, Romain. / Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes. In: Epigenomics. 2019 ; Vol. 11, No. 8. pp. 861-873.

Bibtex

@article{1dfaf37441ed4903b35a3445e465efa5,
title = "Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes",
abstract = "AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.",
author = "Emil Andersen and Ali Altınta{\c s} and Ulrika Andersson-Hall and Agneta Holm{\"a}ng and Romain Barr{\`e}s",
year = "2019",
doi = "10.2217/epi-2019-0055",
language = "English",
volume = "11",
pages = "861--873",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

AU - Andersen, Emil

AU - Altıntaş, Ali

AU - Andersson-Hall, Ulrika

AU - Holmäng, Agneta

AU - Barrès, Romain

PY - 2019

Y1 - 2019

N2 - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

AB - AIM: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors.METHODS: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns.RESULTS: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group.CONCLUSION: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.CLINICAL TRIAL REGISTRATION NUMBER: Dnr 402-08.

U2 - 10.2217/epi-2019-0055

DO - 10.2217/epi-2019-0055

M3 - Journal article

C2 - 30966798

VL - 11

SP - 861

EP - 873

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 8

ER -

ID: 216921552