Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health

Research output: Contribution to journalJournal articlepeer-review

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Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health. / Williams, Kristine; Carrasquilla, Germán D; Ingerslev, Lars Roed; Hochreuter, Mette Yde; Hansson, Svenja; Pillon, Nicolas J; Donkin, Ida; Versteyhe, Soetkin; Zierath, Juleen R; Kilpeläinen, Tuomas O.; Barrès, Romain.

In: Molecular Metabolism, Vol. 53, 101290, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Williams, K, Carrasquilla, GD, Ingerslev, LR, Hochreuter, MY, Hansson, S, Pillon, NJ, Donkin, I, Versteyhe, S, Zierath, JR, Kilpeläinen, TO & Barrès, R 2021, 'Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health', Molecular Metabolism, vol. 53, 101290. https://doi.org/10.1016/j.molmet.2021.101290

APA

Williams, K., Carrasquilla, G. D., Ingerslev, L. R., Hochreuter, M. Y., Hansson, S., Pillon, N. J., Donkin, I., Versteyhe, S., Zierath, J. R., Kilpeläinen, T. O., & Barrès, R. (2021). Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health. Molecular Metabolism, 53, [101290]. https://doi.org/10.1016/j.molmet.2021.101290

Vancouver

Williams K, Carrasquilla GD, Ingerslev LR, Hochreuter MY, Hansson S, Pillon NJ et al. Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health. Molecular Metabolism. 2021;53. 101290. https://doi.org/10.1016/j.molmet.2021.101290

Author

Williams, Kristine ; Carrasquilla, Germán D ; Ingerslev, Lars Roed ; Hochreuter, Mette Yde ; Hansson, Svenja ; Pillon, Nicolas J ; Donkin, Ida ; Versteyhe, Soetkin ; Zierath, Juleen R ; Kilpeläinen, Tuomas O. ; Barrès, Romain. / Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health. In: Molecular Metabolism. 2021 ; Vol. 53.

Bibtex

@article{83d357b6a5384e278083d4d0d6e14a89,
title = "Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health",
abstract = "OBJECTIVES: Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on human health.METHODS AND RESULTS: By studying changes in histone modifications, we mapped the genome-wide positions and activities of enhancers in skeletal muscle biopsies collected from young sedentary men before and after 6 weeks of endurance exercise. We identified extensive remodeling of enhancer activities after exercise training, with a large subset of the remodeled enhancers located in the proximity of genes transcriptionally regulated after exercise. By overlapping the position of enhancers with genetic variants, we identified an enrichment of disease-associated genetic variants within the exercise-remodeled enhancers.CONCLUSION: Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.",
author = "Kristine Williams and Carrasquilla, {Germ{\'a}n D} and Ingerslev, {Lars Roed} and Hochreuter, {Mette Yde} and Svenja Hansson and Pillon, {Nicolas J} and Ida Donkin and Soetkin Versteyhe and Zierath, {Juleen R} and Kilpel{\"a}inen, {Tuomas O.} and Romain Barr{\`e}s",
note = "Copyright {\textcopyright} 2021 The Author(s). Published by Elsevier GmbH.. All rights reserved.",
year = "2021",
doi = "10.1016/j.molmet.2021.101290",
language = "English",
volume = "53",
journal = "Molecular Metabolism",
issn = "2212-8778",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health

AU - Williams, Kristine

AU - Carrasquilla, Germán D

AU - Ingerslev, Lars Roed

AU - Hochreuter, Mette Yde

AU - Hansson, Svenja

AU - Pillon, Nicolas J

AU - Donkin, Ida

AU - Versteyhe, Soetkin

AU - Zierath, Juleen R

AU - Kilpeläinen, Tuomas O.

AU - Barrès, Romain

N1 - Copyright © 2021 The Author(s). Published by Elsevier GmbH.. All rights reserved.

PY - 2021

Y1 - 2021

N2 - OBJECTIVES: Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on human health.METHODS AND RESULTS: By studying changes in histone modifications, we mapped the genome-wide positions and activities of enhancers in skeletal muscle biopsies collected from young sedentary men before and after 6 weeks of endurance exercise. We identified extensive remodeling of enhancer activities after exercise training, with a large subset of the remodeled enhancers located in the proximity of genes transcriptionally regulated after exercise. By overlapping the position of enhancers with genetic variants, we identified an enrichment of disease-associated genetic variants within the exercise-remodeled enhancers.CONCLUSION: Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.

AB - OBJECTIVES: Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on human health.METHODS AND RESULTS: By studying changes in histone modifications, we mapped the genome-wide positions and activities of enhancers in skeletal muscle biopsies collected from young sedentary men before and after 6 weeks of endurance exercise. We identified extensive remodeling of enhancer activities after exercise training, with a large subset of the remodeled enhancers located in the proximity of genes transcriptionally regulated after exercise. By overlapping the position of enhancers with genetic variants, we identified an enrichment of disease-associated genetic variants within the exercise-remodeled enhancers.CONCLUSION: Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.

U2 - 10.1016/j.molmet.2021.101290

DO - 10.1016/j.molmet.2021.101290

M3 - Journal article

C2 - 34252634

VL - 53

JO - Molecular Metabolism

JF - Molecular Metabolism

SN - 2212-8778

M1 - 101290

ER -

ID: 275889594