Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes

Research output: Contribution to journalJournal articlepeer-review

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Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes. / Damgaard, Mads V; Jepsen, Sara L; Ashcroft, Stephen P; Holst, Jens J; Treebak, Jonas T.

In: Nutrients, Vol. 14, No. 18, 3741, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Damgaard, MV, Jepsen, SL, Ashcroft, SP, Holst, JJ & Treebak, JT 2022, 'Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes', Nutrients, vol. 14, no. 18, 3741. https://doi.org/10.3390/nu14183741

APA

Damgaard, M. V., Jepsen, S. L., Ashcroft, S. P., Holst, J. J., & Treebak, J. T. (2022). Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes. Nutrients, 14(18), [3741]. https://doi.org/10.3390/nu14183741

Vancouver

Damgaard MV, Jepsen SL, Ashcroft SP, Holst JJ, Treebak JT. Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes. Nutrients. 2022;14(18). 3741. https://doi.org/10.3390/nu14183741

Author

Damgaard, Mads V ; Jepsen, Sara L ; Ashcroft, Stephen P ; Holst, Jens J ; Treebak, Jonas T. / Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes. In: Nutrients. 2022 ; Vol. 14, No. 18.

Bibtex

@article{dfd29d0c92f44d70b3ab2a92ea9ec2a6,
title = "Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes",
abstract = "Diabetes incidence is rising globally at an accelerating rate causing issues at both the individual and societal levels. However, partly inspired by Ayurvedic medicine, a naturally occurring compound called pterostilbene has been demonstrated to protect against diabetes symptoms, though mainly in rats. The purpose of this study was to investigate the putative protective effect of pterostilbene on the two main aspects of diabetes, namely insulin resistance and decreased insulin secretion, in mice. To accomplish this, we employed diet-induced obese as well as streptozotocin-induced diabetic C57BL/6NTac mice for fasting glucose homeostasis assessment, tolerance tests and pancreas perfusions. In addition, we used the polygenic model of diabetes TALLYHO/JngJ to assess for prevention of β-cell burnout. We found that the diet-induced obese C57BL/6NTac mice were insulin resistant, but that pterostilbene had no impact on this or on overall glucose regulation. We further found that the reported protective effect of pterostilbene against streptozotocin-induced diabetes was absent in C57BL/6NTac mice, despite a promising pilot experiment. Lastly, we observed that pterostilbene does not prevent or delay onset of β-cell burnout in TALLYHO/JngJ mice. In conjunction with the literature, our findings suggest variations in the response to pterostilbene between species or between strains of species.",
keywords = "Animals, Blood Glucose, Diabetes Mellitus, Experimental/drug therapy, Disease Models, Animal, Glucose, Insulin/metabolism, Insulin Secretion, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity/drug therapy, Rats, Stilbenes, Streptozocin",
author = "Damgaard, {Mads V} and Jepsen, {Sara L} and Ashcroft, {Stephen P} and Holst, {Jens J} and Treebak, {Jonas T}",
year = "2022",
doi = "10.3390/nu14183741",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "18",

}

RIS

TY - JOUR

T1 - Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes

AU - Damgaard, Mads V

AU - Jepsen, Sara L

AU - Ashcroft, Stephen P

AU - Holst, Jens J

AU - Treebak, Jonas T

PY - 2022

Y1 - 2022

N2 - Diabetes incidence is rising globally at an accelerating rate causing issues at both the individual and societal levels. However, partly inspired by Ayurvedic medicine, a naturally occurring compound called pterostilbene has been demonstrated to protect against diabetes symptoms, though mainly in rats. The purpose of this study was to investigate the putative protective effect of pterostilbene on the two main aspects of diabetes, namely insulin resistance and decreased insulin secretion, in mice. To accomplish this, we employed diet-induced obese as well as streptozotocin-induced diabetic C57BL/6NTac mice for fasting glucose homeostasis assessment, tolerance tests and pancreas perfusions. In addition, we used the polygenic model of diabetes TALLYHO/JngJ to assess for prevention of β-cell burnout. We found that the diet-induced obese C57BL/6NTac mice were insulin resistant, but that pterostilbene had no impact on this or on overall glucose regulation. We further found that the reported protective effect of pterostilbene against streptozotocin-induced diabetes was absent in C57BL/6NTac mice, despite a promising pilot experiment. Lastly, we observed that pterostilbene does not prevent or delay onset of β-cell burnout in TALLYHO/JngJ mice. In conjunction with the literature, our findings suggest variations in the response to pterostilbene between species or between strains of species.

AB - Diabetes incidence is rising globally at an accelerating rate causing issues at both the individual and societal levels. However, partly inspired by Ayurvedic medicine, a naturally occurring compound called pterostilbene has been demonstrated to protect against diabetes symptoms, though mainly in rats. The purpose of this study was to investigate the putative protective effect of pterostilbene on the two main aspects of diabetes, namely insulin resistance and decreased insulin secretion, in mice. To accomplish this, we employed diet-induced obese as well as streptozotocin-induced diabetic C57BL/6NTac mice for fasting glucose homeostasis assessment, tolerance tests and pancreas perfusions. In addition, we used the polygenic model of diabetes TALLYHO/JngJ to assess for prevention of β-cell burnout. We found that the diet-induced obese C57BL/6NTac mice were insulin resistant, but that pterostilbene had no impact on this or on overall glucose regulation. We further found that the reported protective effect of pterostilbene against streptozotocin-induced diabetes was absent in C57BL/6NTac mice, despite a promising pilot experiment. Lastly, we observed that pterostilbene does not prevent or delay onset of β-cell burnout in TALLYHO/JngJ mice. In conjunction with the literature, our findings suggest variations in the response to pterostilbene between species or between strains of species.

KW - Animals

KW - Blood Glucose

KW - Diabetes Mellitus, Experimental/drug therapy

KW - Disease Models, Animal

KW - Glucose

KW - Insulin/metabolism

KW - Insulin Secretion

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Obese

KW - Obesity/drug therapy

KW - Rats

KW - Stilbenes

KW - Streptozocin

U2 - 10.3390/nu14183741

DO - 10.3390/nu14183741

M3 - Journal article

C2 - 36145121

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 18

M1 - 3741

ER -

ID: 321555265