Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. / Sato, Shogo; Basse, Astrid Linde; Schönke, Milena; Chen, Siwei; Samad, Muntaha; Altıntaş, Ali; Laker, Rhianna C; Dalbram, Emilie; Barrès, Romain; Baldi, Pierre; Treebak, Jonas T.; Zierath, Juleen R; Sassone-Corsi, Paolo.

In: Cell Metabolism, Vol. 30, No. 1, 2019, p. 92-110.e4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sato, S, Basse, AL, Schönke, M, Chen, S, Samad, M, Altıntaş, A, Laker, RC, Dalbram, E, Barrès, R, Baldi, P, Treebak, JT, Zierath, JR & Sassone-Corsi, P 2019, 'Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis', Cell Metabolism, vol. 30, no. 1, pp. 92-110.e4. https://doi.org/10.1016/j.cmet.2019.03.013

APA

Sato, S., Basse, A. L., Schönke, M., Chen, S., Samad, M., Altıntaş, A., Laker, R. C., Dalbram, E., Barrès, R., Baldi, P., Treebak, J. T., Zierath, J. R., & Sassone-Corsi, P. (2019). Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metabolism, 30(1), 92-110.e4. https://doi.org/10.1016/j.cmet.2019.03.013

Vancouver

Sato S, Basse AL, Schönke M, Chen S, Samad M, Altıntaş A et al. Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metabolism. 2019;30(1):92-110.e4. https://doi.org/10.1016/j.cmet.2019.03.013

Author

Sato, Shogo ; Basse, Astrid Linde ; Schönke, Milena ; Chen, Siwei ; Samad, Muntaha ; Altıntaş, Ali ; Laker, Rhianna C ; Dalbram, Emilie ; Barrès, Romain ; Baldi, Pierre ; Treebak, Jonas T. ; Zierath, Juleen R ; Sassone-Corsi, Paolo. / Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. In: Cell Metabolism. 2019 ; Vol. 30, No. 1. pp. 92-110.e4.

Bibtex

@article{1b4c6e238be347b69f86490062dff818,
title = "Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis",
abstract = "While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.",
author = "Shogo Sato and Basse, {Astrid Linde} and Milena Sch{\"o}nke and Siwei Chen and Muntaha Samad and Ali Altınta{\c s} and Laker, {Rhianna C} and Emilie Dalbram and Romain Barr{\`e}s and Pierre Baldi and Treebak, {Jonas T.} and Zierath, {Juleen R} and Paolo Sassone-Corsi",
year = "2019",
doi = "10.1016/j.cmet.2019.03.013",
language = "English",
volume = "30",
pages = "92--110.e4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

AU - Sato, Shogo

AU - Basse, Astrid Linde

AU - Schönke, Milena

AU - Chen, Siwei

AU - Samad, Muntaha

AU - Altıntaş, Ali

AU - Laker, Rhianna C

AU - Dalbram, Emilie

AU - Barrès, Romain

AU - Baldi, Pierre

AU - Treebak, Jonas T.

AU - Zierath, Juleen R

AU - Sassone-Corsi, Paolo

PY - 2019

Y1 - 2019

N2 - While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.

AB - While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.

U2 - 10.1016/j.cmet.2019.03.013

DO - 10.1016/j.cmet.2019.03.013

M3 - Journal article

C2 - 31006592

VL - 30

SP - 92-110.e4

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

ID: 216980626