Microbiome Systems Biology in the Arumugam Group

The Arumugam Group investigates how health and diseases are influenced by our gut microbiome; how the gut microbiome interacts with the host and environmental factors, and how we can therapeutically modulate the gut microbiome to improve health.

Group photo of the Arumugam Group
From left to right: Asker Brejnrod, Mani Arumugam, Tobias Nyholm Wistesen, Vitalina Morozova, Carmen Saenz, Qing Fang, Eleonora Nigro, Thiyagarajan Gnanasekaran, Maria Camila Alvarez Silva, Arjun Sarathi

 

 

 

Genetic background, lifestyle changes and lack of physical activity are important factors involved in metabolic disorders. However, emerging evidence suggests that our gut microbiome and their interactions with us also play an important role in our health and well-being. An imbalance in the gut microbiome may signify an unhealthy state of the host and contribute to obesity and diabetes pathogenesis.

The Arumugam Group aims to study the interactions between the host and the gut microbiome in order to understand the molecular mechanisms underlying metabolic disorders. The Group takes interdisciplinary approaches combining multi-omics microbiome data to study host-microbial crosstalk. The Group also investigates therapeutic approaches to modulate the gut microbiome towards improving human health.

 

 

 

 

 

 

“Enterotypes of the human gut microbiome”
Published in Nature in 2011, this study combines sequenced faecal metagenomes of individuals with previously published data sets and identifies three enterotypes that are not nation or continent specific.

“Roux-en-Y gastric bypass surgery of morbidly obese patients shows swift and persistent changes of the individual gut microbiota”
Published in Genome Medicine in 2016, this study describes the changes in gut microbial taxonomic composition and functional potential following Roux-en-Y gastric bypass in morbidly obese patients.

“Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer”
Published in Nature medicine in 2019, this meta-analysis showed that the gut microbiome dysbiosis signatures in colorectal cancer are truly global, using eight geographically and technically diverse metagenomic studies.

 

 

Novo Nordisk Foundation, Independent Research Fund Denmark, European Union’s Horizon 2020 research and innovation programme, Lundbeck Foundation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group Leader

Mani Arumugam
Associate Professor

Phone +45 23 64 95 52
arumugam@sund.ku.dk

Mani Arumugam

Staff list

Name Title Phone E-mail
Alvarez Silva, Maria Camila Postdoc +4535336512 E-mail
Arumugam, Mani Associate Professor +4535337581 E-mail
Assis, Juliana Postdoc +4535337574 E-mail
Azarm, Asieh Research Assistant +4529658310 E-mail
Buijink, Jesse Arnold Research Assistant   E-mail
Da Rocha Fernandes, Gabriel External   E-mail
Fang, Qing Postdoc +4535327473 E-mail
Gnanasekaran, Thiyagarajan Staff Scientist +4535326899 E-mail
Nigro, Eleonora Research Assistant   E-mail
Saenz, Carmen Postdoc   E-mail
Sarathi, Arjun Research Assistant   E-mail
Thorsen, Jonathan Jan Ilve Postdoc   E-mail
Wistisen, Tobias Nyholm Postdoc +4535334053 E-mail