Mette Andersen Lepola

Mette Andersen Lepola

Assistant Professor


  1. 2023
  2. Published

    A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland

    Thuesen, A. C. B., Stæger, F. F., Kaci, A., Solheim, M. H., Aukrust, I., Jørsboe, E., Santander, C. G., Andersen, M. K., Li, Z., Gilly, A., Stinson, S. E., Gjesing, A. P., Bjerregaard, P., Pedersen, M. L., Larsen, C. V. L., Grarup, N., Jørgensen, M. E., Zeggini, E., Bjørkhaug, L., Njølstad, P. R. & 3 others, Albrechtsen, Anders, Moltke, Ida & Hansen, Torben, 2023, In: The Lancet Regional Health - Europe. 24, 12 p., 100529.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes

    Hansen, A. L., Thomsen, R. W., Brøns, C., Svane, H. M. L., Jensen, Rasmus Tanderup, Lepola, Mette Andersen, Hansen, Torben, Nielsen, J. S., Vestergaard, P., Højlund, K., Jessen, N., Olsen, M. H., Sørensen, H. T. & Vaag, Allan, 2023, In: Diabetologia. 66, p. 1680-1692 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Genetic Loss of Sucrase-Isomaltase Function: Mechanisms, Implications, and Future Perspectives

    Senftleber, N. K., Ramne, Stina, Moltke, Ida, Jørgensen, M. E., Albrechtsen, Anders, Hansen, Torben & Lepola, Mette Andersen, 2023, In: Application of Clinical Genetics. 16, p. 31-39 9 p.

    Research output: Contribution to journalReviewpeer-review

  5. Published

    Genetics of metabolic traits in Greenlanders

    Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen & Hansen, Torben, 2023, In: Danish Medical Journal. 70, 12, 9 p., A05230332.

    Research output: Contribution to journalReviewpeer-review

  6. Published

    Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

    Williamson, A., Norris, D. M., Yin, X., Broadaway, K. A., Moxley, A. H., Vadlamudi, S., Wilson, E. P., Jackson, A. U., Ahuja, V., Andersen, M. K., Arzumanyan, Z., Bonnycastle, L. L., Bornstein, S. R., Bretschneider, M. P., Buchanan, T. A., Chang, Y-C., Chuang, L-M., Chung, R-H., Clausen, T. D., Damm, P. & 31 others, Delgado, G. E., de Mello, V. D., Dupuis, J., Dwivedi, O. P., Erdos, M. R., Silva, L. F., Frayling, T. M., Gieger, C., Goodarzi, M. O., Guo, X., Gustafsson, S., Hakaste, L., Hammar, U., Hatem, G., Herrmann, S., Højlund, K., Horn, K., Jonsson, Anna Elisabet, Kovacs, P., Linneberg, Allan René, Mathiesen, Elisabeth, Friis, Carsten, Stinson, Sara, Suleman, Sufyan, Vistisen, D., Witte, D. R., Hansen, Torben, Lind, L., Schwarz, Peter, Grarup, Niels & Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), M. O. G. A. I. T. C. (., 2023, In: Nature Genetics. 55, 6, p. 973-983 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity

    Stinson, Sara, Jonsson, Anna Elisabet, Lepola, Mette Andersen, Lund, Morten Asp Vonsild, Holm, L. A., Fonvig, Cilius Esmann, Huang, Yun, Stankevic, Evelina, Juel, H. B., Ängquist, Lars, Sørensen, Thorkild I.A., Ongstad, E. L., Gaddipati, R., Grimsby, J., Rhodes, C. J., Pedersen, Oluf Borbye, Christiansen, M., Holm, Jens-Christian & Hansen, Torben, 2023, In: Journal of the American Heart Association. 12, 3, p. 538-544 22 p., e8145.

    Research output: Contribution to journalJournal articlepeer-review

  8. E-pub ahead of print

    Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation

    Frederiksen, T. C., Christiansen, M. K., Benjamin, E. J., Overvad, K., Olsen, A., Lepola, Mette Andersen, Hansen, Torben, Grarup, Niels, Jensen, H. K. & Dahm, C. C., 2023, (E-pub ahead of print) In: Heart.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity

    Lepola, Mette Andersen, Ängquist, Lars, Bork-Jensen, J., Jonsson, Anna Elisabet, Stinson, Sara, Sandholt, C. H., Thodberg, Malte, Pikkupeura, Laura Maarit, Ongstad, E. L., Grarup, Niels, Astrup, A., Pedersen, Oluf Borbye, Williams, K., Barrès, Romain, Sørensen, Thorkild I.A., Linneberg, Allan René, Grimsby, J., Rhodes, C. J. & Hansen, Torben, 2023, In: Diabetes Care. 46, 5, p. 985–992 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Precision subclassification of type 2 diabetes: a systematic review

    Misra, S., Wagner, R., Ozkan, B., Schön, M., Sevilla-Gonzalez, M., Prystupa, K., Wang, C. C., Kreienkamp, R. J., Cromer, S. J., Rooney, M. R., Duan, D., Thuesen, A. C. B., Wallace, A. S., Leong, A., Deutsch, A. J., Andersen, M. K., Billings, L. K., Eckel, R. H., Sheu, W. H-H., Hansen, T. & 8 others, Stefan, N., Goodarzi, M. O., Ray, D., Selvin, E., Florez, J. C., Meigs, J. B., Udler, M. S. & ADA/EASD PMDI, A. P., 2023, In: Communications Medicine. 3, 19 p., 138.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

    Tobias, D. K., Merino, J., Ahmad, A., Aiken, C., Benham, J. L., Bodhini, D., Clark, A. L., Colclough, K., Corcoy, R., Cromer, S. J., Duan, D., Felton, J. L., Francis, E. C., Gillard, P., Gingras, V., Gaillard, R., Haider, E., Hughes, A., Ikle, J. M., Jacobsen, L. M. & 180 others, Kahkoska, A. R., Kettunen, J. L. T., Kreienkamp, R. J., Lim, L. L., Männistö, J. M. E., Massey, R., Mclennan, N. M., Miller, R. G., Morieri, M. L., Most, J., Naylor, R. N., Ozkan, B., Patel, K. A., Pilla, S. J., Prystupa, K., Raghavan, S., Rooney, M. R., Schön, M., Semnani-Azad, Z., Sevilla-Gonzalez, M., Svalastoga, P., Takele, W. W., Tam, C. H. T., Thuesen, Anne Cathrine Baun, Tosur, M., Wallace, A. S., Wang, C. C., Wong, J. J., Yamamoto, J. M., Young, K., Amouyal, C., Lepola, Mette Andersen, Bonham, M. P., Chen, M., Cheng, F., Chikowore, T., Chivers, S. C., Clemmensen, Christoffer, Dabelea, D., Dawed, A. Y., Deutsch, A. J., Dickens, L. T., DiMeglio, L. A., Dudenhöffer-Pfeifer, M., Evans-Molina, C., Fernández-Balsells, M. M., Fitipaldi, H., Fitzpatrick, S. L., Gitelman, S. E., Goodarzi, M. O., Grieger, J. A., Guasch Ferre, Marta, Habibi, N., Hansen, Torben, Huang, C., Harris-Kawano, A., Ismail, H. M., Hoag, B., Johnson, R. K., Jones, A. G., Koivula, R. W., Leong, A., Leung, G. K. W., Libman, I. M., Liu, K., Long, S. A., Lowe, W. L., Morton, R. W., Motala, A. A., Onengut-Gumuscu, S., Pankow, J. S., Pathirana, M., Pazmino, S., Perez, D., Petrie, J. R., Powe, C. E., Quinteros, A., Jain, R., Ray, D., Ried-Larsen, M., Saeed, Z., Santhakumar, V., Kanbour, S., Sarkar, S., Monaco, G. S. F., Scholtens, D. M., Selvin, E., Sheu, W. H. H., Speake, C., Stanislawski, M. A., Steenackers, N., Steck, A. K., Stefan, N., Støy, J., Taylor, R., Tye, S. C., Ukke, G. G., Urazbayeva, M., Van der Schueren, B., Vatier, C., Wentworth, J. M., Hannah, W., White, S. L., Yu, G., Zhang, Y., Zhou, S. J., Beltrand, J., Polak, M., Aukrust, I., de Franco, E., Flanagan, S. E., Maloney, K. A., McGovern, A., Molnes, J., Nakabuye, Mariam, Njølstad, P. R., Pomares-Millan, H., Provenzano, M., Saint-Martin, C., Zhang, C., Zhu, Y., Auh, S., de Souza, R., Fawcett, A. J., Gruber, C., Mekonnen, E. G., Mixter, E., Sherifali, D., Eckel, R. H., Nolan, J. J., Philipson, L. H., Brown, R. J., Billings, L. K., Boyle, K., Costacou, T., Dennis, J. M., Florez, J. C., Gloyn, A. L., Gomez, M. F., Gottlieb, P. A., Greeley, S. A. W., Griffin, K., Hattersley, A. T., Hirsch, I. B., Hivert, M. F., Hood, K. K., Josefson, J. L., Kwak, S. H., Laffel, L. M., Lim, S. S., Loos, Ruth, Ma, R. C. W., Mathieu, C., Mathioudakis, N., Meigs, J. B., Misra, S., Mohan, V., Murphy, R., Oram, R., Owen, K. R., Ozanne, S. E., Pearson, E. R., Perng, W., Pollin, T. I., Pop-Busui, R., Pratley, R. E., Redman, L. M., Redondo, M. J., Reynolds, R. M., Semple, R. K., Sherr, J. L., Sims, E. K., Sweeting, A., Tuomi, T., Udler, M. S., Vesco, K. K., Vilsbøll, Tina, Wagner, R., Rich, S. S. & Franks, P. W., 2023, In: Nature Medicine. 29, 10, p. 2438-2457 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. 2022
  13. Published

    A saturated map of common genetic variants associated with human height

    Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, Karaderi, Tugce, Lin, K., Lull, K., Malden, D. E., Lepola, Mette Andersen, Appadurai, V., Bork-Jensen, J., Burgdorf, Kristoffer Sølvsten, Hansen, Thomas Folkmann, Jonsson, Anna Elisabet, Jorgensen, T., Liu, J., Møllehave, Line Tang, Smit, Roelof Adriaan Johan, Zhao, J., Bisgaard, H., Bønnelykke, Klaus, Dantoft, T. M., Grarup, Niels, Hansen, Torben, Jackson, R. D., Karpe, F., Kovacs, P., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Werge, Thomas, Sun, Y., Loos, Ruth, Winkler, T. W., 23andMe Res Team, 2. R. T., VA Million Vet Program, V. M. V. P., DiscovEHR DiscovEHR MyCode Communi, D. D. M. C., eEMERGE Elect Med Records Genomics, E. E. M. R. G., LifeLines Cohort Study, L. C. S., PRACTICAL consortium, P. C. & Understanding Soc Sci Grp, U. S. S. G., 2022, In: Nature. 610, p. 704–712

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention

    Jørsboe, E., Andersen, M. K., Skotte, L., Stæger, F. F., Færgeman, N. J., Hanghøj, K., Santander, C. G., Senftleber, N. K., Diaz, L. J., Overvad, M., Waples, R. K., Geller, F., Bjerregaard, P., Melbye, M., Larsen, C. V. L., Feenstra, B., Anders Koch, K., Jørgensen, M. E., Grarup, N., Moltke, I. & 2 others, Albrechtsen, Anders & Hansen, Torben, 2022, In: Human Genetics and Genomics Advances. 3, 4, 10 p., 100118.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

    Duncan, C. J. A., Skouboe, M. K., Howarth, S., Hollensen, A. K., Chen, R., Børresen, M. L., Thompson, B. J., Spegarova, J. S., Hatton, C. F., Stæger, F. F., Andersen, M. K., Whittaker, J., Paludan, S. R., Jørgensen, S. E., Thomsen, M. K., Mikkelsen, J. G., Heilmann, C., Buhas, D., Øbro, N. F., Bay, J. T. & 17 others, Marquart, Hanne Vibeke Hansen, Morena, M. T. D. L., Klejka, J. A., Hirschfeld, M., Borgwardt, L., Forss, I., Masmas, T., Poulsen, A., Noya, F., Rouleau, G., Hansen, Torben, Zhou, S., Albrechtsen, Anders, Alizadehfar, R., Allenspach, E. J., Hambleton, S. & Mogensen, T. H., 2022, In: Journal of Experimental Medicine. 219, 6, 26 p., e20212427.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts

    Andersen, M. K., Skotte, L., Jørsboe, E., Polito, R., Stæger, F. F., Aldiss, P., Hanghøj, K., Waples, R. K., Santander, C. G., Grarup, N., Dahl-Petersen, I. K., Diaz, L. J., Overvad, M., Senftleber, N. K., Søborg, B., Larsen, C. V. L., Lemoine, C., Pedersen, O., Feenstra, B., Bjerregaard, P. & 9 others, Melbye, Mads, Jørgensen, M. E., Færgeman, N. J., Koch, A., Moritz, Thomas, Gillum, M. P., Moltke, Ida, Hansen, Torben & Albrechtsen, Anders, 2022, In: Gastroenterology. 162, 4, p. 1171-1182.e3

    Research output: Contribution to journalJournal articlepeer-review

  17. 2020
  18. Published

    Estimating narrow-sense heritability using family data from admixed populations

    Athanasiadis, G., Speed, D., Lepola, Mette Andersen, Appel, E. V. R., Grarup, Niels, Brandslund, I., Jørgensen, M. E., Larsen, C. V. L., Bjerregaard, P., Hansen, Torben & Albrechtsen, Anders, 2020, In: Heredity. 124, 6, p. 751-762 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    New Insights into the Genetics of Latent Autoimmune Diabetes in Adults

    Lepola, Mette Andersen, 2020, In: Current Diabetes Reports. 20, 10 p., 43.

    Research output: Contribution to journalReviewpeer-review

  20. Published

    The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders

    Andersen, M. K., Jørsboe, E., Skotte, L., Hanghøj, K., Sandholt, C. H., Moltke, I., Grarup, N., Kern, T., Mahendran, Y., Søborg, B., Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Tiwari, H. K., Feenstra, B., Koch, A., Wiener, H. W., Hopkins, S. E., Pedersen, O., Melbye, M. & 4 others, Boyer, B. B., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2020, In: PLOS Genetics. 16, 1, 17 p., e1008544.

    Research output: Contribution to journalJournal articlepeer-review

  21. 2019
  22. Published

    Genetics of Latent Autoimmune Diabetes in Adults

    Lepola, Mette Andersen & Hansen, Torben, 2019, In: Current Diabetes Reviews. 15, 3, p. 194-198 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. 2018
  24. Published

    Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population

    Grarup, Niels, Moltke, Ida, Lepola, Mette Andersen, Bjerregaard, P., Larsen, C. V. L., Dahl-Petersen, I. K., Jørsboe, E., Tiwari, H. K., Hopkins, S. E., Wiener, H. W., Boyer, B. B., Linneberg, Allan René, Pedersen, Oluf Borbye, Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 1 Sep 2018, In: Diabetologia. 61, 9, p. 2005–2015

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Genetic architecture of obesity and related metabolic traits - recent insights from isolated populations

    Lepola, Mette Andersen, Grarup, Niels, Moltke, Ida, Albrechtsen, Anders & Hansen, Torben, 2018, In: Current Opinion in Genetics and Development. 50, p. 74-78 5 p.

    Research output: Contribution to journalReviewpeer-review

  26. Published

    Genetics of metabolic traits in Greenlanders: lessons from an isolated population

    Lepola, Mette Andersen & Hansen, Torben, 2018, In: Journal of Internal Medicine. 284, 5, p. 464-477 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

    Grarup, Niels, Moltke, Ida, Lepola, Mette Andersen, Dalby, M., Vitting-Seerup, K., Kern, T. S., Mahendran, Y., Jørsboe, E., Larsen, C. V. L., Dahl-Petersen, I. K., Gilly, A., Suveges, D., Dedoussis, G., Zeggini, E., Pedersen, Oluf Borbye, Andersson, Robin, Bjerregaard, P., Jørgensen, M. E., Albrechtsen, Anders & Hansen, Torben, 2018, In: Nature Genetics. 50, 2, p. 172-174 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. 2016
  29. Published

    Genetics of Type 2 diabetes: the power of isolated populations

    Lepola, Mette Andersen, Pedersen, C. T., Moltke, Ida, Hansen, Torben, Albrechtsen, Anders & Grarup, Niels, 2016, In: Current Diabetes Reports. 16, 7, 9 p., 65.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Identification of novel genetic determinants of erythrocyte membrane fatty acid composition among Greenlanders

    Lepola, Mette Andersen, Jørsboe, E., Sandholt, C. H., Grarup, Niels, Jørgensen, M. E., Færgeman, N. J., Bjerregaard, P., Pedersen, Oluf Borbye, Moltke, Ida, Hansen, Torben & Albrechtsen, Anders, 2016, In: P L o S Genetics. 12, 6, 19 p., e1006119.

    Research output: Contribution to journalJournal articlepeer-review

  31. 2015
  32. Published

    Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies

    Lepola, Mette Andersen & Sandholt, C. H., Dec 2015, In: Current Obesity Reports. 4, 4, p. 401-10 10 p.

    Research output: Contribution to journalJournal articlepeer-review

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