Genomics of Obesity and Metabolic Health in the Kilpeläinen Group

The Kilpeläinen Group investigates the influence of genes on obesity and metabolic health, to find new ways to prevent obesity-related metabolic diseases.

Group photo of the Kilpeläinen Group
From left to right: Malene Revsbech Christiansen, Sophia Metz, Germán D. Carrasquilla, Tuomas O. Kilpeläinen, Mario García Ureña, Katja Thorøe Michler, Markus Hodal Drag, Romain Charmet

 

 

 

 

The Kilpeläinen group utilizes genomic, molecular and health data, to understand how obesity drives metabolic disease.

 Obesity is associated with poor metabolic health and increased risk of type 2 diabetes and cardiovascular disease. However, the impact of weight gain on metabolic health varies widely between individuals due to differences in the location, composition and function of adipose tissue. The overarching aim of the Kilpeläinen group is to identify causal mechanisms that influence adipose tissue characteristics upon weight gain and find ways to target these mechanisms.

 The research in Kilpeläinen group is inter-disciplinary, utilizing both computational and experimental approaches. Genetic association data from large populations are combined with results from high-throughput cellular and tissue-based assays and in vivo models. Through in-depth understanding of the mechanisms that link obesity to metabolic disease, the group seeks to open avenues for new treatments.

 

 

 

 

 

 

"Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity"
Published in Diabetes in 2020, this study finds that both coding and non-coding variants of the leptin gene are linked to childhood adiposity.

"Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity"
Published in Nature Communications in 2019, this study uses data from >250,000 adults to identify genetic variants for which the effects on lipid levels are modified by physical activity.

"Obesity, unfavorable lifestyle and genetic risk of type 2 diabetes"
Published in Diabetologia in 2020, this study finds that having normal body weight is crucial in the prevention of type 2 diabetes, regardless of genetic predisposition.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group Leader

Tuomas Oskari Kilpeläinen
Associate Professor

Phone: +45 3533 2247
tuomas.kilpelainen@sund.ku.dk

Tuomas Oskari Kilpeläinen

Staff list

Name Title Phone E-mail
Belanich, Jonathan Robert Postdoc +4535326559 E-mail
Carrasquilla, Germán D. Assistant Professor +4535334595 E-mail
Charmet, Romain Michel-Louis To Postdoc +4535335316 E-mail
Christiansen, Malene Revsbech PhD Student +4535322249 E-mail
Drag, Markus Hodal Postdoc +4535331325 E-mail
García Ureña, Mario PhD Fellow   E-mail
Gál, Boglár Master Student   E-mail
Hecq, Aurore External   E-mail
Huang, Yuejiao Research Assistant   E-mail
Jakupovic, Hermina Research Assistant +4535334674 E-mail
Metz, Sophia PhD Student +4535336653 E-mail
Mosnier, Alizée Erasmus Master Student   E-mail
Oskari Kilpeläinen, Tuomas Associate Professor +4535332247 E-mail
Romero Lado, María José Master Student   E-mail
Sánchez Lorente, Javier Master Student   E-mail