Metabolomics Research in the Moritz Group

Our goal is to use metabolomics approaches to study the role of metabolites and lipids in metabolism. By using mass spectrometry based methods we can screen for 100s to 1000s compounds or target specific compounds in different biological systems. We hope to be able to uncover the basic role of metabolites in metabolism and their role in developing diseases.

Group photo of the members of the MoritzGroup
From left to right: Thomas Moritz, Lidia Argemi Muntadas, Adnan Khan, Matthias Mattanovich, Luis Rodrigo Cataldo Bascunan

 

 

 

Understanding basic metabolism is necessary for understanding how metabolic diseases are developed, and thereby being able to develop effective diagnostics and treatments.

Moritz group uses metabolomics approaches to understand the role of the metabolome in controlling different aspects of metabolism in humans. We are studying the metabolome and fluxomes in different cell types as well performing large scale analysis on human plasma cohorts. An important part of the research is to develop methodology for analyzing the metabolome. The method development covers strategies for sample preparation, mass spectrometry analysis and data processing.

Professor Thomas Moritz explains: “Continuously improving and developing methods is necessary but it must be the biological questions that determine what is needed”.

 

 

 

 

 

 

  1. High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses
    Published in Analytical Chemistry 2005, showing a principle how to process GC-MS based metabolomics data files, for identifying differences between samples in a fast and efficient way.
  2. Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by 13C-labelling
    Published in J. of Exp. Bot., by using 13C-labelling we studied to which extent the lack of the major isoform of mitochondrial malate dehydrogenase (mMDH1) mMDH1, affected metabolism.
  3. Functional metabolomics as a tool to analyze mediator function and structure in plants
    Published in PlosOne 2017, showing that metabolomics can be used for prediction of biochemical function. The example in on the Mediator complex. With metabolomics and appropriate data analysis tools, we could predict where in the Mediator complex the different subunits are located.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group Leader

Thomas Moritz
Professor

Phone: +45 3533 1390
thomas.moritz@sund.ku.dk

Thomas Moritz

Staff list

Name Title Phone E-mail
Argemi Muntadas, Lidia PhD Student +4535335394 E-mail
Cataldo Bascunan, Luis Rodrigo Postdoc   E-mail
Khan, Adnan Postdoc   E-mail
Moritz, Thomas Professor +4535331390 E-mail
Novais Rodrigues, Raissa Academic Research Officer   E-mail