Health Promoting Microbiome Research in the Pedersen Group
The research focus is to investigate how specific commensal and mutualistic gut bacteria as well as the total collective of trillions of gut bacteria influence metabolic health of the human host. The ultimate perspectives include discovery and characterization of novel microbial compounds for prevention or treatment of common metabolic dysfunctions like metabolic syndrome, obesity, type 2 diabetes, obesity, and overt atherosclerosis.
We combine extensive physiological examinations of cohorts of healthy individuals and patients with well-defined metabolic dysfunctions with omics-based analyses of a variety of biological samples from the study participants.
The omics approaches include metagenomics, metabolomics, proteomics and genomics. The generated data are bioinformatically analysed and integrated. We test the relevance and validity of the outcome experimentally in molecular-, cellular- and animal studies and in human interventions.
Human gut microbes impact host serum metabolome and insulin sensitivity
The study points to the role of specific gut bacteria and their derived microbial molecules involved in human insulin resistance.
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
The findings emphasize the need to separate authentic disease signatures of the intestinal microbiome from those which are introduced by prescribed drugs.
Richness of human gut microbiome correlates with metabolic markers
The study demonstrates how low gut microbial gene richness relates to insulin resistance, inflammation and increased body adiposity.
|Allin, Kristine Højgaard||Associate Professor||Pedersen Group, Health Promoting Microbiome Research||+4535337055|
|Andersson, Anna Jasmine||External Researcher||Pedersen Group, Health Promoting Microbiome Research|
|Clos Garcia, Marc||Postdoc||Pedersen Group, Health Promoting Microbiome Research||+4535326093|
|Dutta, Avirup||External||Pedersen Group, Health Promoting Microbiome Research||+4535334231|
|Fan, Yong||Postdoc||Pedersen Group, Health Promoting Microbiome Research||+4593509187|
|Hansen, Tue Haldor||External|
|Huang, Lam Opal||Staff Scientist||Pedersen Group, Health Promoting Microbiome Research||+4535333037|
|Lyu, Liwei||Academic Research Officer||Pedersen Group, Health Promoting Microbiome Research||+4593509186|
|López Navarro, Miriam||Master Student||Pedersen Group, Health Promoting Microbiome Research||+4535336264|
|Pedersen, Helle Krogh||External Researcher||Pedersen Group, Health Promoting Microbiome Research||+4535333325|
|Pedersen, Oluf Borbye||Professor||Group Leader, Pedersen Group, Health Promoting Microbiome Research||+4529382526|
|Rodriguez Garcia, Paula||Master Student||Pedersen Group, Health Promoting Microbiome Research|
|Søndertoft, Nadja Buus||Postdoc||Pedersen Group, Health Promoting Microbiome Research||+4535337091|
|Vogt, Josef Korbinian||External||+4535330789|
|Winther, Signe Abitz||External||Pedersen Group, Health Promoting Microbiome Research|